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Chem Commun (Camb). 2017 Sep 21;53(76):10508-10511. doi: 10.1039/c7cc05722a.

Origins of the enhanced affinity of RNA-protein interactions triggered by RNA phosphorodithioate backbone modification.

Author information

1
AM Biotechnologies, LLC, 12521 Gulf Freeway, Houston, TX 77034, USA. xianbin.yang@am-biotech.com xianbin@hotmail.com.

Abstract

The well-characterized interaction between the MS2 coat protein and its cognate RNA hairpin was used to evaluate changes in affinity as a result of phosphorodithioate (PS2) replacing phosphate by biolayer interferometry (BLI). A structure-based analysis of the data provides insights into the origins of the enhanced affinity of RNA-protein interactions triggered by the PS2 moiety.

PMID:
28868553
PMCID:
PMC5608642
DOI:
10.1039/c7cc05722a
[Indexed for MEDLINE]
Free PMC Article

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