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Bone Marrow Transplant. 2015 Feb;50(2):216-20. doi: 10.1038/bmt.2014.248. Epub 2014 Nov 10.

Onset and outcome of pregnancy after autologous haematopoietic SCT (AHSCT) for autoimmune diseases: a retrospective study of the EBMT autoimmune diseases working party (ADWP).

Author information

1
Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland.
2
Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust & University of Sheffield, Sheffield, UK.
3
Division of Clinical Immunology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
4
Division of Hematology, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
5
EBMT Paris Study Office, ADWP-EBMT, Hopital Saint-Antoine, Assistance Publique des Hôpitaux de Paris, UPMC Univ Paris 06, UMR-S 938, Paris, France.
6
Department of Haematology, University Hospital, Uppsala, Sweden.
7
1] Department of Neurosciences, Uppsala University, Uppsala, Sweden [2] Department of Neurology, Uppsala University Hospital, Uppsala, Sweden.
8
The Haematology and Bone Marrow Transplant Department, St Vincent's Hospital, Sydney, NSW, Australia.
9
BMT Unit, Hematology Department, Hospital Clinic and Institut d'Investigació Biomèdiques August PI i Sunyer (IDIBAPS), Barcelona, Spain.
10
Department of Hematology, Royal Liverpool University Hospital, Liverpool, UK.
11
Neurology Service, Hospital Clinic and Institut d'Investigació Biomèdiques August PI i Sunyer (IDIBAPS), Barcelona, Spain.
12
Department of Internal Medicine, CHU Purpan, Toulouse, France.
13
Unità Operativa di Oncoematologia e Trapianto di Midollo, Ospedale La Maddalena, Palermo, Italy.
14
Strasbourg University Hospital CNRS UPR 3572, Strasbourg, France.
15
Internal Medicine and Vascular Disease Unit UH 04, Assistance Publique Hôpitaux de Paris, INSERM UMRS 1160, France.

Abstract

Autologous haematopoietic SCT (AHSCT) is increasingly used to control severe and refractory autoimmune diseases (AD). Many patients are women of reproductive age with a potential desire for children. We present a multicentre retrospective analysis of pregnancy and childbirth in patients who underwent AHSCT for AD. The databases of the European Blood and Marrow Transplantation and University of Sao Paulo, Ribeirão Preto, Brazil were searched for female patients aged 18-50 years who had received AHSCT for AD between 1994-2011. In 324 adult female patients, 22 pregnancies were reported in 15 patients between 1997-2011. Indications for AHSCT included multiple sclerosis (n=7), systemic sclerosis (n=5), rheumatoid arthritis (n=1), juvenile idiopathic arthritis (n=1) and Takayasu disease (n=1). Of the 22 reported pregnancies, 20 followed natural conception. 15 pregnancies (68%) resulted in healthy life births, whereas 7 (32%) failed. Exacerbations of AD occurred in two patients during second pregnancies. No maternal mortality was associated with pregnancy or postpartum. There were no reports of congenital, developmental or any other disease in the children. This retrospective analysis confirms the possibility of pregnancy and childbirth following AHSCT for severe AD. The outcome of pregnancy is generally good and most led to the birth of a healthy child.

PMID:
25387098
DOI:
10.1038/bmt.2014.248
[Indexed for MEDLINE]

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