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Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1957 3
1961 2
1962 2
1963 4
1964 1
1967 1
1976 1
1977 1
1978 1
1979 4
1980 1
1981 7
1982 6
1983 4
1984 5
1985 9
1986 9
1987 14
1988 13
1989 10
1990 8
1991 8
1992 10
1993 16
1994 17
1995 25
1996 18
1997 22
1998 24
1999 30
2000 26
2001 24
2002 19
2003 20
2004 16
2005 24
2006 25
2007 40
2008 36
2009 35
2010 23
2011 33
2012 37
2013 32
2014 31
2015 23
2016 28
2017 34
2018 33
2019 27
2020 28
2021 26
2022 25
2023 31
2024 11

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890 results

Results by year

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Page 1
Validation of a New Methodology to Create Oral Drugs beyond the Rule of 5 for Intracellular Tough Targets.
Ohta A, Tanada M, Shinohara S, Morita Y, Nakano K, Yamagishi Y, Takano R, Kariyuki S, Iida T, Matsuo A, Ozeki K, Emura T, Sakurai Y, Takano K, Higashida A, Kojima M, Muraoka T, Takeyama R, Kato T, Kimura K, Ogawa K, Ohara K, Tanaka S, Kikuchi Y, Hisada N, Hayashi R, Nishimura Y, Nomura K, Tachibana T, Irie M, Kawada H, Torizawa T, Murao N, Kotake T, Tanaka M, Ishikawa S, Miyake T, Tamiya M, Arai M, Chiyoda A, Akai S, Sase H, Kuramoto S, Ito T, Shiraishi T, Kojima T, Iikura H. Ohta A, et al. J Am Chem Soc. 2023 Nov 8;145(44):24035-24051. doi: 10.1021/jacs.3c07145. Epub 2023 Oct 24. J Am Chem Soc. 2023. PMID: 37874670
Evidence-based clinical practice guideline for adult Still's disease.
Mimura T, Kondo Y, Ohta A, Iwamoto M, Ota A, Okamoto N, Kawaguchi Y, Kono H, Takasaki Y, Takei S, Nishimoto N, Fujimoto M, Asanuma YF, Mimori A, Okiyama N, Kaneko S, Takahashi H, Yokosawa M, Sumida T. Mimura T, et al. Among authors: ohta a. Mod Rheumatol. 2018 Sep;28(5):736-757. doi: 10.1080/14397595.2018.1465633. Epub 2018 May 9. Mod Rheumatol. 2018. PMID: 29651907 Review.
The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.
Imamura K, Izumi Y, Watanabe A, Tsukita K, Woltjen K, Yamamoto T, Hotta A, Kondo T, Kitaoka S, Ohta A, Tanaka A, Watanabe D, Morita M, Takuma H, Tamaoka A, Kunath T, Wray S, Furuya H, Era T, Makioka K, Okamoto K, Fujisawa T, Nishitoh H, Homma K, Ichijo H, Julien JP, Obata N, Hosokawa M, Akiyama H, Kaneko S, Ayaki T, Ito H, Kaji R, Takahashi R, Yamanaka S, Inoue H. Imamura K, et al. Among authors: ohta a. Sci Transl Med. 2017 May 24;9(391):eaaf3962. doi: 10.1126/scitranslmed.aaf3962. Sci Transl Med. 2017. PMID: 28539470 Free article.
Development of Orally Bioavailable Peptides Targeting an Intracellular Protein: From a Hit to a Clinical KRAS Inhibitor.
Tanada M, Tamiya M, Matsuo A, Chiyoda A, Takano K, Ito T, Irie M, Kotake T, Takeyama R, Kawada H, Hayashi R, Ishikawa S, Nomura K, Furuichi N, Morita Y, Kage M, Hashimoto S, Nii K, Sase H, Ohara K, Ohta A, Kuramoto S, Nishimura Y, Iikura H, Shiraishi T. Tanada M, et al. Among authors: ohta a. J Am Chem Soc. 2023 Aug 2;145(30):16610-16620. doi: 10.1021/jacs.3c03886. Epub 2023 Jul 18. J Am Chem Soc. 2023. PMID: 37463267
AJM300 (carotegrast methyl), an oral antagonist of α4-integrin, as induction therapy for patients with moderately active ulcerative colitis: a multicentre, randomised, double-blind, placebo-controlled, phase 3 study.
Matsuoka K, Watanabe M, Ohmori T, Nakajima K, Ishida T, Ishiguro Y, Kanke K, Kobayashi K, Hirai F, Watanabe K, Mizusawa H, Kishida S, Miura Y, Ohta A, Kajioka T, Hibi T; AJM300 Study Group. Matsuoka K, et al. Among authors: ohta a. Lancet Gastroenterol Hepatol. 2022 Jul;7(7):648-657. doi: 10.1016/S2468-1253(22)00022-X. Epub 2022 Mar 30. Lancet Gastroenterol Hepatol. 2022. PMID: 35366419 Clinical Trial.
2,6-Dimeth-oxy-9,10-anthraquinone.
Ohta A, Hattori K, Kobayashi T, Naito H, Kawase T, Kitamura C. Ohta A, et al. Acta Crystallogr Sect E Struct Rep Online. 2012 Oct 1;68(Pt 10):o2843. doi: 10.1107/S1600536812037361. Epub 2012 Sep 5. Acta Crystallogr Sect E Struct Rep Online. 2012. PMID: 23125647 Free PMC article.
2,3,6,7-Tetra-meth-oxy-9,10-anthra-quinone.
Ohta A, Hattori K, Kawase T, Kobayashi T, Naito H, Kitamura C. Ohta A, et al. Acta Crystallogr Sect E Struct Rep Online. 2012 Aug 1;68(Pt 8):o2587. doi: 10.1107/S1600536812033119. Epub 2012 Jul 28. Acta Crystallogr Sect E Struct Rep Online. 2012. PMID: 22905012 Free PMC article.
890 results