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Page 1
17,20S(OH)(2)pD Can Prevent the Development of Skin Fibrosis in the Bleomycin-Induced Scleroderma Mouse Model.
Brown Lobbins ML, Scott IO, Slominski AT, Hasty KA, Zhang S, Miller DD, Li W, Kim TK, Janjetovic Z, Patel TS, Myers LK, Postlethwaite AE. Brown Lobbins ML, et al. Int J Mol Sci. 2021 Aug 19;22(16):8926. doi: 10.3390/ijms22168926. Int J Mol Sci. 2021. PMID: 34445632 Free PMC article.
In summary, 17,20S(OH)(2)pD modulates the mediators of fibrosis in vivo and suppresses total collagen production and dermal thickness. This antifibrotic property of 17,20S(OH)(2)pD offers new therapeutic approaches for fibrotic disorders....
In summary, 17,20S(OH)(2)pD modulates the mediators of fibrosis in vivo and suppresses total collagen production and dermal th …
Chemical synthesis, biological activities and action on nuclear receptors of 20S(OH)D(3), 20S,25(OH)(2)D(3), 20S,23S(OH)(2)D(3) and 20S,23R(OH)(2)D(3).
Brzeminski P, Fabisiak A, Slominski RM, Kim TK, Janjetovic Z, Podgorska E, Song Y, Saleem M, Reddy SB, Qayyum S, Song Y, Tuckey RC, Atigadda V, Jetten AM, Sicinski RR, Raman C, Slominski AT. Brzeminski P, et al. Bioorg Chem. 2022 Apr;121:105660. doi: 10.1016/j.bioorg.2022.105660. Epub 2022 Feb 8. Bioorg Chem. 2022. PMID: 35168121 Free PMC article.
New and more efficient routes of chemical synthesis of vitamin D(3) (D(3)) hydroxy (OH) metabolites, including 20S(OH)D(3), 20S,23S(OH)(2)D(3) and 20S,25(OH)(2)D(3), that are endogenously produced in the human body by CYP11A1, and …
New and more efficient routes of chemical synthesis of vitamin D(3) (D(3)) hydroxy (OH) metabolites, including 20S(OH)D …
Modulation by 17,20S(OH)(2)pD of Fibrosis-Related Mediators in Dermal Fibroblast Lines from Healthy Donors and from Patients with Systemic Sclerosis.
Brown Lobbins ML, Slominski AT, Hasty KA, Zhang S, Miller DD, Li W, Kim TK, Janjetovic Z, Tuckey RC, Scott IO, Myers LK, Postlethwaite AE. Brown Lobbins ML, et al. Int J Mol Sci. 2021 Dec 29;23(1):367. doi: 10.3390/ijms23010367. Int J Mol Sci. 2021. PMID: 35008794 Free PMC article.
Fibroblasts were cultured with either 17,20S(OH)(2)pD or 1,25(OH)(2)D(3) (positive control) with/without TGF-beta1 stimulation and extracted for protein and/or mRNA for collagen synthesis and mediators of fibrosis (MMP-1, TIMP-1, PAI-1, BMP-7, PGES, GLI1, and …
Fibroblasts were cultured with either 17,20S(OH)(2)pD or 1,25(OH)(2)D(3) (positive control) with/without TGF-beta1 stim …
Investigation of 20S-hydroxyvitamin D(3) analogs and their 1alpha-OH derivatives as potent vitamin D receptor agonists with anti-inflammatory activities.
Lin Z, Marepally SR, Goh ESY, Cheng CYS, Janjetovic Z, Kim TK, Miller DD, Postlethwaite AE, Slominski AT, Tuckey RC, Peluso-Iltis C, Rochel N, Li W. Lin Z, et al. Sci Rep. 2018 Jan 24;8(1):1478. doi: 10.1038/s41598-018-19183-7. Sci Rep. 2018. PMID: 29367669 Free PMC article.
20S-hydroxyvitamin D(3) [20S(OH)D(3)] is anti-inflammatory and not hypercalcemic, suggesting its potential as a lead compound. ...This study demonstrates the potential of the 20S(OH)D(3) scaffold for the development of novel anti-inflammatory ag …
20S-hydroxyvitamin D(3) [20S(OH)D(3)] is anti-inflammatory and not hypercalcemic, suggesting its potential as a lead co …
(20S,2''S)-20-[4'-(3''-Hydroxy-2''-methyl-prop-yl)-3'-methylisoxazol-5-yl]-5beta-preg-nan-3beta,16beta-diol.
Hernández Linares MG, Sandoval Ramírez J, Meza Reyes S, Montiel Smith S, Bernès S. Hernández Linares MG, et al. Acta Crystallogr Sect E Struct Rep Online. 2009 Nov 28;65(Pt 12):o3265-6. doi: 10.1107/S1600536809050478. Acta Crystallogr Sect E Struct Rep Online. 2009. PMID: 21578960 Free PMC article.
The absolute configuration observed for chiral centers is as expected, and shows that no epimerization occurred in the precursors. In the crystal, the three OH groups serve as donors for hydrogen bonding with O and N atoms. ...
The absolute configuration observed for chiral centers is as expected, and shows that no epimerization occurred in the precursors. In the cr …
The serum vitamin D metabolome: What we know and what is still to discover.
Tuckey RC, Cheng CYS, Slominski AT. Tuckey RC, et al. J Steroid Biochem Mol Biol. 2019 Feb;186:4-21. doi: 10.1016/j.jsbmb.2018.09.003. Epub 2018 Sep 8. J Steroid Biochem Mol Biol. 2019. PMID: 30205156 Free PMC article. Review.
CYP11A1 which catalyzes the first step in steroidogenesis, has been found to also act on vitamins D3 and D2 hydroxylating both at C20, but with some secondary metabolites produced by subsequent hydroxylations at other positions on the side chain. The major vitamin D3 metabolite, …
CYP11A1 which catalyzes the first step in steroidogenesis, has been found to also act on vitamins D3 and D2 hydroxylating both at C20, but w …
20S-Hydroxyvitamin D3, a Secosteroid Produced in Humans, Is Anti-Inflammatory and Inhibits Murine Autoimmune Arthritis.
Postlethwaite AE, Tuckey RC, Kim TK, Li W, Bhattacharya SK, Myers LK, Brand DD, Slominski AT. Postlethwaite AE, et al. Front Immunol. 2021 Jun 30;12:678487. doi: 10.3389/fimmu.2021.678487. eCollection 2021. Front Immunol. 2021. PMID: 34276665 Free PMC article.
Cytochrome P450scc (CYP11A1) is able to convert D3 into the noncalcemic analog 20S-hydroxyvitamin D3 [20S(OH)D3]. We demonstrate that 20S(OH)D3 markedly suppresses clinical signs of arthritis and joint damage in a mouse model of RA. Furthermore, …
Cytochrome P450scc (CYP11A1) is able to convert D3 into the noncalcemic analog 20S-hydroxyvitamin D3 [20S(OH)D3]. We de …
Total synthesis of biologically active 20S-hydroxyvitamin D3.
Wang Q, Lin Z, Kim TK, Slominski AT, Miller DD, Li W. Wang Q, et al. Steroids. 2015 Dec;104:153-62. doi: 10.1016/j.steroids.2015.09.009. Epub 2015 Oct 1. Steroids. 2015. PMID: 26433048 Free PMC article.
A total synthetic strategy of 20S-hydroxyvitamin D3 [20S-(OH)D3] involving modified synthesis of key intermediates 7 and 12, Grignard reaction to stereoselectively generate 20S-OH and Wittig-Horner coupling to establish D3 framework, was complet …
A total synthetic strategy of 20S-hydroxyvitamin D3 [20S-(OH)D3] involving modified synthesis of key intermediates 7 an …
1alpha,20S-Dihydroxyvitamin D(3) Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis.
Lin Z, Chen H, Belorusova AY, Bollinger JC, Tang EKY, Janjetovic Z, Kim TK, Wu Z, Miller DD, Slominski AT, Postlethwaite AE, Tuckey RC, Rochel N, Li W. Lin Z, et al. Sci Rep. 2017 Aug 31;7(1):10193. doi: 10.1038/s41598-017-10917-7. Sci Rep. 2017. PMID: 28860545 Free PMC article.
1alpha,20S-Dihydroxyvitamin D3 [1,20S(OH)(2)D(3)], a natural and bioactive vitamin D3 metabolite, was chemically synthesized for the first time. ...Furthermore, this study provides a synthetic route for the synthesis of 1,20S(OH)(2)D(3) using th …
1alpha,20S-Dihydroxyvitamin D3 [1,20S(OH)(2)D(3)], a natural and bioactive vitamin D3 metabolite, was chemically synthe …
216 results