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Items: 1 to 20 of 105


Location and Cell-Type-Specific Bias of Metabotropic Glutamate Receptor, mGlu5, Negative Allosteric Modulators.

Jong YI, Harmon SK, O'Malley KL.

ACS Chem Neurosci. 2019 Nov 20;10(11):4558-4570. doi: 10.1021/acschemneuro.9b00415. Epub 2019 Oct 28.


Intracellular GPCRs Play Key Roles in Synaptic Plasticity.

Jong YI, Harmon SK, O'Malley KL.

ACS Chem Neurosci. 2018 Sep 19;9(9):2162-2172. doi: 10.1021/acschemneuro.7b00516. Epub 2018 Feb 16. Review.


GPCR signalling from within the cell.

Jong YI, Harmon SK, O'Malley KL.

Br J Pharmacol. 2018 Nov;175(21):4026-4035. doi: 10.1111/bph.14023. Epub 2017 Oct 3. Review.


Sequences within the C Terminus of the Metabotropic Glutamate Receptor 5 (mGluR5) Are Responsible for Inner Nuclear Membrane Localization.

Sergin I, Jong YI, Harmon SK, Kumar V, O'Malley KL.

J Biol Chem. 2017 Mar 3;292(9):3637-3655. doi: 10.1074/jbc.M116.757724. Epub 2017 Jan 17.


Mechanisms Associated with Activation of Intracellular Metabotropic Glutamate Receptor, mGluR5.

Jong YI, O'Malley KL.

Neurochem Res. 2017 Jan;42(1):166-172. doi: 10.1007/s11064-016-2026-6. Epub 2016 Aug 11.


Intracellular mGluR5 plays a critical role in neuropathic pain.

Vincent K, Cornea VM, Jong YI, Laferrière A, Kumar N, Mickeviciute A, Fung JST, Bandegi P, Ribeiro-da-Silva A, O'Malley KL, Coderre TJ.

Nat Commun. 2016 Feb 3;7:10604. doi: 10.1038/ncomms10604.


Comprehensive functional characterization of murine infantile Batten disease including Parkinson-like behavior and dopaminergic markers.

Dearborn JT, Harmon SK, Fowler SC, O'Malley KL, Taylor GT, Sands MS, Wozniak DF.

Sci Rep. 2015 Aug 4;5:12752. doi: 10.1038/srep12752.


Reassessment of the role of aromatic amino acid hydroxylases and the effect of infection by Toxoplasma gondii on host dopamine.

Wang ZT, Harmon S, O'Malley KL, Sibley LD.

Infect Immun. 2015 Mar;83(3):1039-47. doi: 10.1128/IAI.02465-14. Epub 2014 Dec 29.


Location-dependent signaling of the group 1 metabotropic glutamate receptor mGlu5.

Jong YJ, Sergin I, Purgert CA, O'Malley KL.

Mol Pharmacol. 2014 Dec;86(6):774-85. doi: 10.1124/mol.114.094763. Epub 2014 Oct 17. Review.


Functional G protein-coupled receptors on nuclei from brain and primary cultured neurons.

Jong YJ, O'Malley KL.

Methods Mol Biol. 2015;1234:113-21. doi: 10.1007/978-1-4939-1755-6_10.


The Parkinsonian mimetic, 6-OHDA, impairs axonal transport in dopaminergic axons.

Lu X, Kim-Han JS, Harmon S, Sakiyama-Elbert SE, O'Malley KL.

Mol Neurodegener. 2014 May 3;9:17. doi: 10.1186/1750-1326-9-17.


Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus.

Purgert CA, Izumi Y, Jong YJ, Kumar V, Zorumski CF, O'Malley KL.

J Neurosci. 2014 Mar 26;34(13):4589-98. doi: 10.1523/JNEUROSCI.3451-13.2014.


MPP+-induces PUMA- and p53-dependent, but ATF3-independent cell death.

Bernstein AI, O'Malley KL.

Toxicol Lett. 2013 May 23;219(2):93-8. doi: 10.1016/j.toxlet.2013.03.003. Epub 2013 Mar 14.


Sequences located within the N-terminus of the PD-linked LRRK2 lead to increased aggregation and attenuation of 6-hydroxydopamine-induced cell death.

Pandey N, Fahey MT, Jong YJ, O'Malley KL.

PLoS One. 2012;7(9):e45149. doi: 10.1371/journal.pone.0045149. Epub 2012 Sep 13.


A microdevice platform for visualizing mitochondrial transport in aligned dopaminergic axons.

Lu X, Kim-Han JS, O'Malley KL, Sakiyama-Elbert SE.

J Neurosci Methods. 2012 Jul 30;209(1):35-9. doi: 10.1016/j.jneumeth.2012.05.021. Epub 2012 May 28.


WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity.

Antenor-Dorsey JA, O'Malley KL.

Mol Neurodegener. 2012 Feb 8;7:5. doi: 10.1186/1750-1326-7-5.


Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein.

Kumar V, Fahey PG, Jong YJ, Ramanan N, O'Malley KL.

J Biol Chem. 2012 Feb 17;287(8):5412-25. doi: 10.1074/jbc.M111.301366. Epub 2011 Dec 16.


The role of axonopathy in Parkinson's disease.

O'Malley KL.

Exp Neurobiol. 2010 Dec;19(3):115-9. doi: 10.5607/en.2010.19.3.115. Epub 2010 Dec 31.


The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons.

Kim-Han JS, Antenor-Dorsey JA, O'Malley KL.

J Neurosci. 2011 May 11;31(19):7212-21. doi: 10.1523/JNEUROSCI.0711-11.2011.


6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death.

Bernstein AI, Garrison SP, Zambetti GP, O'Malley KL.

Mol Neurodegener. 2011 Jan 6;6(1):2. doi: 10.1186/1750-1326-6-2.

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