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Items: 1 to 20 of 103

1.

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70.

Zhao M, Svensson MND, Venken K, Chawla A, Liang S, Engel I, Mydel P, Day J, Elewaut D, Bottini N, Kronenberg M.

Nat Commun. 2018 Jul 6;9(1):2627. doi: 10.1038/s41467-018-05095-7.

2.

Nitric Oxide Dependent Degradation of Polyethylene Glycol-Modified Single-Walled Carbon Nanotubes: Implications for Intra-Articular Delivery.

Bhattacharya K, Sacchetti C, Costa PM, Sommertune J, Brandner BD, Magrini A, Rosato N, Bottini N, Bottini M, Fadeel B.

Adv Healthc Mater. 2018 Mar;7(6):e1700916. doi: 10.1002/adhm.201700916. Epub 2018 Jan 15.

PMID:
29334180
3.

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis.

Sacchetti C, Bai Y, Stanford SM, Di Benedetto P, Cipriani P, Santelli E, Piera-Velazquez S, Chernitskiy V, Kiosses WB, Ceponis A, Kaestner KH, Boin F, Jimenez SA, Giacomelli R, Zhang ZY, Bottini N.

Nat Commun. 2017 Oct 20;8(1):1060. doi: 10.1038/s41467-017-01168-1.

4.

Targeting Tyrosine Phosphatases: Time to End the Stigma.

Stanford SM, Bottini N.

Trends Pharmacol Sci. 2017 Jun;38(6):524-540. doi: 10.1016/j.tips.2017.03.004. Epub 2017 Apr 12. Review.

5.

Protein Tyrosine Phosphatases in Systemic Sclerosis: Potential Pathogenic Players and Therapeutic Targets.

Sacchetti C, Bottini N.

Curr Rheumatol Rep. 2017 May;19(5):28. doi: 10.1007/s11926-017-0655-7. Review.

PMID:
28397126
6.

Diabetes reversal by inhibition of the low-molecular-weight tyrosine phosphatase.

Stanford SM, Aleshin AE, Zhang V, Ardecky RJ, Hedrick MP, Zou J, Ganji SR, Bliss MR, Yamamoto F, Bobkov AA, Kiselar J, Liu Y, Cadwell GW, Khare S, Yu J, Barquilla A, Chung TDY, Mustelin T, Schenk S, Bankston LA, Liddington RC, Pinkerton AB, Bottini N.

Nat Chem Biol. 2017 Jun;13(6):624-632. doi: 10.1038/nchembio.2344. Epub 2017 Mar 27.

7.

Epigenetic alterations in rheumatoid arthritis fibroblast-like synoviocytes.

Doody KM, Bottini N, Firestein GS.

Epigenomics. 2017 Apr;9(4):479-492. doi: 10.2217/epi-2016-0151. Epub 2017 Mar 21. Review.

8.

CD45-mediated control of TCR tuning in naïve and memory CD8+ T cells.

Cho JH, Kim HO, Ju YJ, Kye YC, Lee GW, Lee SW, Yun CH, Bottini N, Webster K, Goodnow CC, Surh CD, King C, Sprent J.

Nat Commun. 2016 Nov 14;7:13373. doi: 10.1038/ncomms13373.

9.

Abnormal PTPN11 enhancer methylation promotes rheumatoid arthritis fibroblast-like synoviocyte aggressiveness and joint inflammation.

Maeshima K, Stanford SM, Hammaker D, Sacchetti C, Zeng LF, Ai R, Zhang V, Boyle DL, Aleman Muench GR, Feng GS, Whitaker JW, Zhang ZY, Wang W, Bottini N, Firestein GS.

JCI Insight. 2016 May 19;1(7). pii: e86580.

10.

T-helper signals restore B-cell receptor signaling in autoreactive anergic B cells by upregulating CD45 phosphatase activity.

Szodoray P, Stanford SM, Molberg Ø, Munthe LA, Bottini N, Nakken B.

J Allergy Clin Immunol. 2016 Sep;138(3):839-851.e8. doi: 10.1016/j.jaci.2016.01.035. Epub 2016 Apr 4.

PMID:
27056269
11.

Nanodrugs to target articular cartilage: An emerging platform for osteoarthritis therapy.

Bottini M, Bhattacharya K, Fadeel B, Magrini A, Bottini N, Rosato N.

Nanomedicine. 2016 Feb;12(2):255-68. doi: 10.1016/j.nano.2015.09.013. Epub 2015 Dec 18. Review.

PMID:
26707894
12.

Chondrocyte clocks make cartilage time-sensitive material.

Doody KM, Bottini N.

J Clin Invest. 2016 Jan;126(1):38-9. doi: 10.1172/JCI85632. Epub 2015 Dec 14.

13.

Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.

Fraser HI, Howlett S, Clark J, Rainbow DB, Stanford SM, Wu DJ, Hsieh YW, Maine CJ, Christensen M, Kuchroo V, Sherman LA, Podolin PL, Todd JA, Steward CA, Peterson LB, Bottini N, Wicker LS.

J Immunol. 2015 Nov 15;195(10):4841-52. doi: 10.4049/jimmunol.1402654. Epub 2015 Oct 5.

14.

Receptor Protein Tyrosine Phosphatase α-Mediated Enhancement of Rheumatoid Synovial Fibroblast Signaling and Promotion of Arthritis in Mice.

Stanford SM, Svensson MN, Sacchetti C, Pilo CA, Wu DJ, Kiosses WB, Hellvard A, Bergum B, Muench GR, Elly C, Liu YC, den Hertog J, Elson A, Sap J, Mydel P, Boyle DL, Corr M, Firestein GS, Bottini N.

Arthritis Rheumatol. 2016 Feb;68(2):359-69. doi: 10.1002/art.39442.

15.

Decade in review-translational rheumatology: Ten years after: rheumatology research from bench to bedside.

Bottini N, Firestein GS.

Nat Rev Rheumatol. 2015 Nov;11(11):623-4. doi: 10.1038/nrrheum.2015.126. Epub 2015 Sep 22. No abstract available.

PMID:
26390844
16.

Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.

Wade F, Quijada P, Al-Haffar KM, Awad SM, Kunhi M, Toko H, Marashly Q, Belhaj K, Zahid I, Al-Mohanna F, Stanford SM, Alvarez R, Liu Y, Colak D, Jordan MC, Roos KP, Assiri A, Al-Habeeb W, Sussman M, Bottini N, Poizat C.

J Pathol. 2015 Dec;237(4):482-94. doi: 10.1002/path.4594. Epub 2015 Sep 1.

17.

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays.

Kiris E, Nuss JE, Stanford SM, Wanner LM, Cazares L, Maestre MF, Du HT, Gomba GY, Burnett JC, Gussio R, Bottini N, Panchal RG, Kane CD, Tessarollo L, Bavari S.

PLoS One. 2015 Jun 10;10(6):e0129264. doi: 10.1371/journal.pone.0129264. eCollection 2015.

18.

Targeting phosphatase-dependent proteoglycan switch for rheumatoid arthritis therapy.

Doody KM, Stanford SM, Sacchetti C, Svensson MN, Coles CH, Mitakidis N, Kiosses WB, Bartok B, Fos C, Cory E, Sah RL, Liu-Bryan R, Boyle DL, Arnett HA, Mustelin T, Corr M, Esko JD, Tremblay ML, Firestein GS, Aricescu AR, Bottini N.

Sci Transl Med. 2015 May 20;7(288):288ra76. doi: 10.1126/scitranslmed.aaa4616.

19.

Allosteric Small Molecule Inhibitors of LMPTP.

Ardecky RJ, Hedrick MP, Stanford SM, Bliss MR, Zou J, Gosalia P, Yamamoto F, Milewski M, Barron N, Sun Q, Ganji S, Mehta A, Sugarman E, Nguyen K, Vasile S, Suyama E, Mangravita-Novo A, Salaniwal S, Kung P, Smith LH, Sergienko E, Chung TDY, Pinkerton AB, Bottini N.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2014 Apr 15 [updated 2015 Jan 16].

20.

Polyethylene-glycol-modified single-walled carbon nanotubes for intra-articular delivery to chondrocytes.

Sacchetti C, Liu-Bryan R, Magrini A, Rosato N, Bottini N, Bottini M.

ACS Nano. 2014 Dec 23;8(12):12280-91. doi: 10.1021/nn504537b. Epub 2014 Nov 26.

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