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Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis.
Gurel B, Iwata T, Koh CM, Jenkins RB, Lan F, Van Dang C, Hicks JL, Morgan J, Cornish TC, Sutcliffe S, Isaacs WB, Luo J, De Marzo AM. Gurel B, et al. Mod Pathol. 2008 Sep;21(9):1156-67. doi: 10.1038/modpathol.2008.111. Epub 2008 Jun 20. Mod Pathol. 2008. PMID: 18567993 Free PMC article.
Nuclear overexpression of MYC protein occurred frequently in luminal cells of PIN, as well as in most primary carcinomas and metastatic disease. ...These results provide evidence that upregulation of nuclear MYC protein expression
Nuclear overexpression of MYC protein occurred frequently in luminal cells of PIN, as well as in most primary ca
MYC overexpression induces prostatic intraepithelial neoplasia and loss of Nkx3.1 in mouse luminal epithelial cells.
Iwata T, Schultz D, Hicks J, Hubbard GK, Mutton LN, Lotan TL, Bethel C, Lotz MT, Yegnasubramanian S, Nelson WG, Dang CV, Xu M, Anele U, Koh CM, Bieberich CJ, De Marzo AM. Iwata T, et al. PLoS One. 2010 Feb 25;5(2):e9427. doi: 10.1371/journal.pone.0009427. PLoS One. 2010. PMID: 20195545 Free PMC article.
Lo-MYC and Hi-MYC mice develop prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma as a result of MYC overexpression in the mouse prostate. ...To determine the effects of less pronounced overexpression of …
Lo-MYC and Hi-MYC mice develop prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma as a resul …