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Items: 12


Pten Haplodeficiency Accelerates Liver Tumor Growth in miR-122a-Null Mice via Expansion of Periportal Hepatocyte-Like Cells.

Tu WL, You LR, Tsou AP, Chen CM.

Am J Pathol. 2018 Nov;188(11):2688-2702. doi: 10.1016/j.ajpath.2018.07.019. Epub 2018 Aug 27.


Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.

Lee YY, Mok MT, Kang W, Yang W, Tang W, Wu F, Xu L, Yan M, Yu Z, Lee SD, Tong JHM, Cheung YS, Lai PBS, Yu DY, Wang Q, Wong GLH, Chan AM, Yip KY, To KF, Cheng ASL.

Nucleic Acids Res. 2018 Sep 28;46(17):8832-8847. doi: 10.1093/nar/gky589.


The mechanisms of genome-wide target gene regulation by TCF7L2 in liver cells.

Norton L, Chen X, Fourcaudot M, Acharya NK, DeFronzo RA, Heikkinen S.

Nucleic Acids Res. 2014 Dec 16;42(22):13646-61. doi: 10.1093/nar/gku1225. Epub 2014 Nov 20.


Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer.

Saha SK, Parachoniak CA, Ghanta KS, Fitamant J, Ross KN, Najem MS, Gurumurthy S, Akbay EA, Sia D, Cornella H, Miltiadous O, Walesky C, Deshpande V, Zhu AX, Hezel AF, Yen KE, Straley KS, Travins J, Popovici-Muller J, Gliser C, Ferrone CR, Apte U, Llovet JM, Wong KK, Ramaswamy S, Bardeesy N.

Nature. 2014 Sep 4;513(7516):110-4. doi: 10.1038/nature13441. Epub 2014 Jul 2. Erratum in: Nature. 2015 Dec 3;528(7580):152.


A double-negative feedback loop between Wnt-β-catenin signaling and HNF4α regulates epithelial-mesenchymal transition in hepatocellular carcinoma.

Yang M, Li SN, Anjum KM, Gui LX, Zhu SS, Liu J, Chen JK, Liu QF, Ye GD, Wang WJ, Wu JF, Cai WY, Sun GB, Liu YJ, Liu RF, Zhang ZM, Li BA.

J Cell Sci. 2013 Dec 15;126(Pt 24):5692-703. doi: 10.1242/jcs.135053. Epub 2013 Oct 7.


Hepatocyte nuclear factor 4 alpha deletion promotes diethylnitrosamine-induced hepatocellular carcinoma in rodents.

Walesky C, Edwards G, Borude P, Gunewardena S, O'Neil M, Yoo B, Apte U.

Hepatology. 2013 Jun;57(6):2480-90. doi: 10.1002/hep.26251.


Hepatocyte nuclear factor 4 alpha suppresses the development of hepatocellular carcinoma.

Ning BF, Ding J, Yin C, Zhong W, Wu K, Zeng X, Yang W, Chen YX, Zhang JP, Zhang X, Wang HY, Xie WF.

Cancer Res. 2010 Oct 1;70(19):7640-51. doi: 10.1158/0008-5472.CAN-10-0824. Epub 2010 Sep 28.


Integrative and comparative genomics analysis of early hepatocellular carcinoma differentiated from liver regeneration in young and old.

Colak D, Chishti MA, Al-Bakheet AB, Al-Qahtani A, Shoukri MM, Goyns MH, Ozand PT, Quackenbush J, Park BH, Kaya N.

Mol Cancer. 2010 Jun 12;9:146. doi: 10.1186/1476-4598-9-146.


[Hepatocyte nuclear factor 4 (HNF4) in epithelial development and carcinogenesis].

Lazarevich NL, Al'pern DV.

Mol Biol (Mosk). 2008 Sep-Oct;42(5):786-97. Review. Russian.


Differentiation therapy of hepatocellular carcinoma in mice with recombinant adenovirus carrying hepatocyte nuclear factor-4alpha gene.

Yin C, Lin Y, Zhang X, Chen YX, Zeng X, Yue HY, Hou JL, Deng X, Zhang JP, Han ZG, Xie WF.

Hepatology. 2008 Nov;48(5):1528-39. doi: 10.1002/hep.22510.


EPS15R, TASP1, and PRPF3 are novel disease candidate genes targeted by HNF4alpha splice variants in hepatocellular carcinomas.

Niehof M, Borlak J.

Gastroenterology. 2008 Apr;134(4):1191-202. doi: 10.1053/j.gastro.2008.01.027. Epub 2008 Jan 17.


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