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Items: 10


Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer.

Ishaque N, Abba ML, Hauser C, Patil N, Paramasivam N, Huebschmann D, Leupold JH, Balasubramanian GP, Kleinheinz K, Toprak UH, Hutter B, Benner A, Shavinskaya A, Zhou C, Gu Z, Kerssemakers J, Marx A, Moniuszko M, Kozlowski M, Reszec J, Niklinski J, Eils J, Schlesner M, Eils R, Brors B, Allgayer H.

Nat Commun. 2018 Nov 14;9(1):4782. doi: 10.1038/s41467-018-07041-z.


Hepatocyte nuclear factor 1α suppresses steatosis-associated liver cancer by inhibiting PPARγ transcription.

Patitucci C, Couchy G, Bagattin A, Cañeque T, de Reyniès A, Scoazec JY, Rodriguez R, Pontoglio M, Zucman-Rossi J, Pende M, Panasyuk G.

J Clin Invest. 2017 May 1;127(5):1873-1888. doi: 10.1172/JCI90327. Epub 2017 Apr 10.


Role of Akt2 in regulation of metastasis suppressor 1 expression and colorectal cancer metastasis.

Agarwal E, Robb CM, Smith LM, Brattain MG, Wang J, Black JD, Chowdhury S.

Oncogene. 2017 Jun 1;36(22):3104-3118. doi: 10.1038/onc.2016.460. Epub 2017 Jan 9.


Spontaneous Hepatocellular Carcinoma after the Combined Deletion of Akt Isoforms.

Wang Q, Yu WN, Chen X, Peng XD, Jeon SM, Birnbaum MJ, Guzman G, Hay N.

Cancer Cell. 2016 Apr 11;29(4):523-535. doi: 10.1016/j.ccell.2016.02.008. Epub 2016 Mar 17.


Activated mutant forms of PIK3CA cooperate with RasV12 or c-Met to induce liver tumour formation in mice via AKT2/mTORC1 cascade.

Wang C, Che L, Hu J, Zhang S, Jiang L, Latte G, Demartis MI, Tao J, Gui B, Pilo MG, Ribback S, Dombrowski F, Evert M, Calvisi DF, Chen X.

Liver Int. 2016 Aug;36(8):1176-86. doi: 10.1111/liv.13055. Epub 2016 Jan 30.


miRNA-302b suppresses human hepatocellular carcinoma by targeting AKT2.

Wang L, Yao J, Zhang X, Guo B, Le X, Cubberly M, Li Z, Nan K, Song T, Huang C.

Mol Cancer Res. 2014 Feb;12(2):190-202. doi: 10.1158/1541-7786.MCR-13-0411. Epub 2013 Dec 13.


Crosstalk of Ras and Rho: activation of RhoA abates Kras-induced liver tumorigenesis in transgenic zebrafish models.

Chew TW, Liu XJ, Liu L, Spitsbergen JM, Gong Z, Low BC.

Oncogene. 2014 May 22;33(21):2717-27. doi: 10.1038/onc.2013.240. Epub 2013 Jul 1.


Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis.

Rychahou PG, Kang J, Gulhati P, Doan HQ, Chen LA, Xiao SY, Chung DH, Evers BM.

Proc Natl Acad Sci U S A. 2008 Dec 23;105(51):20315-20. doi: 10.1073/pnas.0810715105. Epub 2008 Dec 15.


X-Linked inhibitor of apoptosis protein expression level in colorectal cancer is regulated by hepatocyte growth factor/C-met pathway via Akt signaling.

Takeuchi H, Kim J, Fujimoto A, Umetani N, Mori T, Bilchik A, Turner R, Tran A, Kuo C, Hoon DS.

Clin Cancer Res. 2005 Nov 1;11(21):7621-8.

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