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Items: 1 to 20 of 97


Adverse outcome pathway-driven identification of rat liver tumorigens in short-term assays.

Rooney J, Hill T 3rd, Qin C, Sistare FD, Corton JC.

Toxicol Appl Pharmacol. 2018 Oct 1;356:99-113. doi: 10.1016/j.taap.2018.07.023. Epub 2018 Jul 23.


The aryl hydrocarbon receptor in the crossroad of signalling networks with therapeutic value.

Roman ÁC, Carvajal-Gonzalez JM, Merino JM, Mulero-Navarro S, Fernández-Salguero PM.

Pharmacol Ther. 2018 May;185:50-63. doi: 10.1016/j.pharmthera.2017.12.003. Epub 2017 Dec 16. Review.


Sedaxane-Use of Nuclear Receptor Transactivation Assays, Toxicogenomics, and Toxicokinetics as Part of a Mode of Action Framework for Rodent Liver Tumors.

Peffer RC, Cowie DE, Currie RA, Minnema DJ.

Toxicol Sci. 2018 Apr 1;162(2):582-598. doi: 10.1093/toxsci/kfx281.


From the Cover: Genomic Effects of Androstenedione and Sex-Specific Liver Cancer Susceptibility in Mice.

Rooney JP, Ryan N, Chorley BN, Hester SD, Kenyon EM, Schmid JE, George BJ, Hughes MF, Sey YM, Tennant A, MacMillan DK, Simmons JE, McQueen CA, Pandiri A, Wood CE, Corton JC.

Toxicol Sci. 2017 Nov 1;160(1):15-29. doi: 10.1093/toxsci/kfx153.


Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer.

Khanal T, Choi K, Leung YK, Wang J, Kim D, Janakiram V, Cho SG, Puga A, Ho SM, Kim K.

Sci Rep. 2017 Sep 6;7(1):10662. doi: 10.1038/s41598-017-11106-2.


Allyl isothiocyanate, a potent chemopreventive agent targets AhR/Nrf2 signaling pathway in chemically induced mammary carcinogenesis.

Rajakumar T, Pugalendhi P, Thilagavathi S, Ananthakrishnan D, Gunasekaran K.

Mol Cell Biochem. 2018 Jan;437(1-2):1-12. doi: 10.1007/s11010-017-3091-0. Epub 2017 Jun 5.


Comparative Analysis and Functional Characterization of HC-AFW1 Hepatocarcinoma Cells: Cytochrome P450 Expression and Induction by Nuclear Receptor Agonists.

Braeuning A, Thomas M, Hofmann U, Vetter S, Zeller E, Petzuch B, Johänning J, Schroth W, Weiss TS, Zanger UM, Schwarz M.

Drug Metab Dispos. 2015 Nov;43(11):1781-7. doi: 10.1124/dmd.115.064667. Epub 2015 Aug 26.


Hexachlorobenzene induces cell proliferation, and aryl hydrocarbon receptor expression (AhR) in rat liver preneoplastic foci, and in the human hepatoma cell line HepG2. AhR is a mediator of ERK1/2 signaling, and cell cycle regulation in HCB-treated HepG2 cells.

de Tomaso Portaz AC, Caimi GR, Sánchez M, Chiappini F, Randi AS, Kleiman de Pisarev DL, Alvarez L.

Toxicology. 2015 Oct 2;336:36-47. doi: 10.1016/j.tox.2015.07.013. Epub 2015 Jul 26.


Mechanistic Investigation of Toxaphene Induced Mouse Liver Tumors.

Wang Z, Neal BH, Lamb JC, Klaunig JE.

Toxicol Sci. 2015 Oct;147(2):549-61. doi: 10.1093/toxsci/kfv151. Epub 2015 Jul 16.


Activating and Inhibitory Functions of WNT/β-Catenin in the Induction of Cytochromes P450 by Nuclear Receptors in HepaRG Cells.

Thomas M, Bayha C, Vetter S, Hofmann U, Schwarz M, Zanger UM, Braeuning A.

Mol Pharmacol. 2015 Jun;87(6):1013-20. doi: 10.1124/mol.114.097402. Epub 2015 Mar 30.


Inhibition of de novo NAD(+) synthesis by oncogenic URI causes liver tumorigenesis through DNA damage.

Tummala KS, Gomes AL, Yilmaz M, Graña O, Bakiri L, Ruppen I, Ximénez-Embún P, Sheshappanavar V, Rodriguez-Justo M, Pisano DG, Wagner EF, Djouder N.

Cancer Cell. 2014 Dec 8;26(6):826-839. doi: 10.1016/j.ccell.2014.10.002. Epub 2014 Nov 20.


Interactive effects of inflammatory cytokine and abundant low-molecular-weight PAHs on inhibition of gap junctional intercellular communication, disruption of cell proliferation control, and the AhR-dependent transcription.

Kabátková M, Svobodová J, Pěnčíková K, Mohatad DS, Šmerdová L, Kozubík A, Machala M, Vondráček J.

Toxicol Lett. 2015 Jan 5;232(1):113-21. doi: 10.1016/j.toxlet.2014.09.023. Epub 2014 Sep 28.


Dietary extra-virgin olive oil and corn oil differentially modulate the mRNA expression of xenobiotic-metabolizing enzymes in the liver and in the mammary gland in a rat chemically induced breast cancer model.

Manzanares MÁ, Solanas M, Moral R, Escrich R, Vela E, Costa I, Escrich E.

Eur J Cancer Prev. 2015 May;24(3):215-22. doi: 10.1097/CEJ.0000000000000032.


Liver tumor promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin is dependent on the aryl hydrocarbon receptor and TNF/IL-1 receptors.

Kennedy GD, Nukaya M, Moran SM, Glover E, Weinberg S, Balbo S, Hecht SS, Pitot HC, Drinkwater NR, Bradfield CA.

Toxicol Sci. 2014 Jul;140(1):135-43. doi: 10.1093/toxsci/kfu065. Epub 2014 Apr 9.


Comparisons of differential gene expression elicited by TCDD, PCB126, βNF, or ICZ in mouse hepatoma Hepa1c1c7 cells and C57BL/6 mouse liver.

Nault R, Forgacs AL, Dere E, Zacharewski TR.

Toxicol Lett. 2013 Oct 23;223(1):52-9. doi: 10.1016/j.toxlet.2013.08.013. Epub 2013 Aug 29.


RNA-Seq profiling reveals novel hepatic gene expression pattern in aflatoxin B1 treated rats.

Merrick BA, Phadke DP, Auerbach SS, Mav D, Stiegelmeyer SM, Shah RR, Tice RR.

PLoS One. 2013 Apr 22;8(4):e61768. doi: 10.1371/journal.pone.0061768. Print 2013.


Involvement of PTEN/Akt signaling and oxidative stress on indole-3-carbinol (I3C)-induced hepatocarcinogenesis in rats.

Yamamoto R, Shimamoto K, Ishii Y, Kimura M, Fujii Y, Morita R, Suzuki K, Shibutani M, Mitsumori K.

Exp Toxicol Pathol. 2013 Sep;65(6):845-52. doi: 10.1016/j.etp.2012.12.003. Epub 2013 Jan 4.


Cyprodinil as an activator of aryl hydrocarbon receptor.

Fang CC, Chen FY, Chen CR, Liu CC, Wong LC, Liu YW, Su JG.

Toxicology. 2013 Feb 8;304:32-40. doi: 10.1016/j.tox.2012.11.018. Epub 2012 Dec 7.


Expression of genes involved in xenobiotic metabolism and transport in end-stage liver disease: up-regulation of ABCC4 and CYP1B1.

Kurzawski M, Dziedziejko V, Post M, Wójcicki M, Urasińska E, Miętkiewski J, Droździk M.

Pharmacol Rep. 2012;64(4):927-39.


Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action.

Hayashi H, Shimamoto K, Taniai E, Ishii Y, Morita R, Suzuki K, Shibutani M, Mitsumori K.

J Toxicol Sci. 2012;37(3):491-501.

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