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Genes Dev. 2011 Jul 15;25(14):1476-85. doi: 10.1101/gad.2064111. Epub 2011 Jun 29.

Nitric oxide coordinates metabolism, growth, and development via the nuclear receptor E75.

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Banting and Best Department of Medical Research, Department of Molecular Biology, University of Toronto, Ontario, Canada.


Nitric oxide gas acts as a short-range signaling molecule in a vast array of important physiological processes, many of which include major changes in gene expression. How these genomic responses are induced, however, is poorly understood. Here, using genetic and chemical manipulations, we show that nitric oxide is produced in the Drosophila prothoracic gland, where it acts via the nuclear receptor ecdysone-induced protein 75 (E75), reversing its ability to interfere with its heterodimer partner, Drosophila hormone receptor 3 (DHR3). Manipulation of these interactions leads to gross alterations in feeding behavior, fat deposition, and developmental timing. These neuroendocrine interactions and consequences appear to be conserved in vertebrates.

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