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Arch Oral Biol. 2018 Dec;96:137-145. doi: 10.1016/j.archoralbio.2018.08.013. Epub 2018 Aug 24.

New animal model of extrinsic dental erosion-Erosive effect on the mouse molar teeth.

Author information

1
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Postboks 1052 Blindern, 0316 Oslo, Norway. Electronic address: amela.tulek@odont.uio.no.
2
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Postboks 1052 Blindern, 0316 Oslo, Norway. Electronic address: muhammad.saeed@odont.uio.no.
3
Nordic Institute of Dental Materials (NIOM AS), Sognsveien 70A, 0855 Oslo, Norway. Electronic address: aida.mulic@niom.no.
4
Department of Cariology, Institute of Clinical Dentistry, University of Oslo, Postboks 1109 Blindern, 0317 Oslo, Norway. Electronic address: k.r.stenhagen@odont.uio.no.
5
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Postboks 1052 Blindern, 0316 Oslo, Norway; Department of Medical Biochemistry, Oslo University Hospital, Postboks 4950 Nydalen, 0424 Oslo, Norway; Department of Maxillofacial Surgery, Oslo University Hospital, Postboks 4950 Nydalen, 0424 Oslo, Norway. Electronic address: utheim2@gmail.com.
6
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Postboks 1052 Blindern, 0316 Oslo, Norway. Electronic address: h.k.galtung@odont.uio.no.
7
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Postboks 1052 Blindern, 0316 Oslo, Norway. Electronic address: n.k.c.khuu@odont.uio.no.
8
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Postboks 1052 Blindern, 0316 Oslo, Norway. Electronic address: minou.nirvani@odont.uio.no.
9
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Postboks 1052 Blindern, 0316 Oslo, Norway. Electronic address: m.s.kristiansen@odont.uio.no.
10
Department of Oral Biology, Faculty of Dentistry, University of Oslo, Postboks 1052 Blindern, 0316 Oslo, Norway; Department of Maxillofacial Surgery, Oslo University Hospital, Postboks 4950 Nydalen, 0424 Oslo, Norway. Electronic address: amer.sehic@odont.uio.no.

Abstract

OBJECTIVE:

Consumption of acidic food and drinks is considered as important risk factor for development of dental erosion. There are several in vitro and in situ studies focusing on the risk indicators and preventive treatment, however, the need for a standardized animal model has been emphasised for many years. The aim was to establish an animal model of extrinsic dental erosion, which may serve as a standard for future studies to improve our understanding of the erosion.

DESIGN:

Two acidic drinks, sports drink and cola drink, were given to young mice for six weeks. Experimental and control (water) molars and incisors were dissected out and observed by scanning electron microscopy (SEM). Mandibular first molars were subsequently ground transversely and observed again by SEM. The tooth height and enamel thickness were measured on the SEM images.

RESULTS:

The lingual surface of the mandibular molars was most eroded after consumption of acidic drinks. The cola drink exhibited higher erosive effect on mandibular molars compared to sports drink. The lingual tooth height, compared to control, was about 34% and 18% lower in the cola drink and sports drink molars, respectively. Compared to the control molars, the lingual enamel was about 23% thinner in the sports drink molars and totally eroded on the certain lingual areas of the cola drink molars.

CONCLUSIONS:

This new animal model of extrinsic dental erosion and the presented method with ground molars observed in SEM are suitable for further studies, which will gain deeper insights into the erosive disease.

KEYWORDS:

Acidic drinks; Animal model; Dental enamel; Dental erosive wear; Scanning electron microscopy

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