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Curr Allergy Asthma Rep. 2016 Aug;16(8):57. doi: 10.1007/s11882-016-0637-2.

New Insights Into the Relationship Between Chitinase-3-Like-1 and Asthma.

Author information

1
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
2
Department of Immunology, International Branch of Aras, Tabriz University of Medical Sciences, Tabriz, Iran.
3
Student's Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
4
Tropical Medicine Laboratory Consultancy, Amsterdam, The Netherlands. apbussink@tropmedlab.nl.

Abstract

PURPOSE OF REVIEW:

CHI3L1 (also known as YKL-40), a member of "mammalian chitinase-like proteins," is a serum protein lacking enzymatic activity. Although the protein is highly conserved in mammals, a consensus regarding its role in human pathologies is currently lacking. In an attempt to shed light on the many physiological functions of the protein, specifically with regard to asthma, a comprehensive overview of recent studies is provided.

RECENT FINDINGS:

In asthma, CHI3L1 is secreted from macrophages and airway epithelial cells through an IL-13 related mechanism. Th2-associated inflammatory responses due to allergen exposure, resulting in airway hyper-responsiveness and smooth muscle contraction, play a role in tissue remodeling. The importance of CHI3L1 in initiation and development of asthma is not limited to its involvement in highly orchestrated events of inflammatory cytokines but further research is needed for further elucidation. Levels of the protein are associated with severity for numerous pathologies, including asthma, suggesting limited specificity as a biomarker.

KEYWORDS:

Asthma; Biomarker; CD4+Th2 lymphocytes; CHI3L1; Chitinase; Chitinase-like protein; IL-13; IL-4; SNP; YKL-40

PMID:
27438466
DOI:
10.1007/s11882-016-0637-2
[Indexed for MEDLINE]

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