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FEMS Yeast Res. 2015 Nov;15(7). pii: fov081. doi: 10.1093/femsyr/fov081. Epub 2015 Sep 6.

Candida albicans commensalism in the gastrointestinal tract.

Author information

1
Institut Pasteur, Unité Biologie et Pathogénicité Fongiques, Département Mycologie, F-75015 Paris, France INRA, USC2019, F-75015 Paris, France.
2
Institut Pasteur, Unité Biologie et Pathogénicité Fongiques, Département Mycologie, F-75015 Paris, France INRA, USC2019, F-75015 Paris, France christophe.denfert@pasteur.fr.
3
Institut Pasteur, Unité Biologie et Pathogénicité Fongiques, Département Mycologie, F-75015 Paris, France INRA, USC2019, F-75015 Paris, France Laboratoire de Parasitologie-Mycologie, Service de Microbiologie, Hôpital Necker-Enfants Malades, Université Paris Descartes, Faculté de Médicine, F-75015 Paris, France.

Abstract

Candida albicans is a polymorphic yeast species that often forms part of the commensal gastrointestinal mycobiota of healthy humans. It is also an important opportunistic pathogen. A tripartite interaction involving C. albicans, the resident microbiota and host immunity maintains C. albicans in its commensal form. The influence of each of these factors on C. albicans carriage is considered herein, with particular focus on the mycobiota and the approaches used to study it, models of gastrointestinal colonization by C. albicans, the C. albicans genes and phenotypes that are necessary for commensalism and the host factors that influence C. albicans carriage.

KEYWORDS:

Candida albicans; animal models; commensalism; gastrointestinal tract; immunity; microbiota; mycobiota

PMID:
26347504
DOI:
10.1093/femsyr/fov081
[Indexed for MEDLINE]

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