Format

Send to

Choose Destination

See 1 citation found by title matching your search:

J Cereb Blood Flow Metab. 2013 Jan;33(1):97-105. doi: 10.1038/jcbfm.2012.137. Epub 2012 Oct 3.

Neurovascular coupling varies with level of global cerebral ischemia in a rat model.

Author information

1
Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, PA 19104, USA. wbaker@sas.upenn.edu

Abstract

In this study, cerebral blood flow, oxygenation, metabolic, and electrical functional responses to forepaw stimulation were monitored in rats at different levels of global cerebral ischemia from mild to severe. Laser speckle contrast imaging and optical imaging of intrinsic signals were used to measure changes in blood flow and oxygenation, respectively, along with a compartmental model to calculate changes in oxygen metabolism from these measured changes. To characterize the electrical response to functional stimulation, we measured somatosensory evoked potentials (SEPs). Global graded ischemia was induced through unilateral carotid artery occlusion, bilateral carotid artery occlusion, bilateral carotid and right subclavian artery (SCA) occlusion, or carotid and SCA occlusion with negative lower body pressure. We found that the amplitude of the functional metabolic response remained tightly coupled to the amplitude of the SEP at all levels of ischemia observed. However, as the level of ischemia became more severe, the flow response was more strongly attenuated than the electrical response, suggesting that global ischemia was associated with an uncoupling between the functional flow and electrical responses.

PMID:
23032485
PMCID:
PMC3597370
DOI:
10.1038/jcbfm.2012.137
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center