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J Neurosci. 2015 Apr 22;35(16):6506-16. doi: 10.1523/JNEUROSCI.4489-14.2015.

Neurogenetic variations in norepinephrine availability enhance perceptual vividness.

Author information

1
Department of Psychology, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada, becket.todd@psych.ubc.ca.
2
Department of Psychology, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada.
3
Department of Psychiatry, University of Toronto and Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, M5T 1R8, Canada.
4
Department of Psychology, University of Toronto, Toronto, Ontario, M5S 3G3, Canada.
5
Department of Psychology, University of Toronto, Toronto, Ontario, M5S 3G3, Canada, Rotman Research Institute, Baycrest Health Sciences, Toronto, Ontario, M6A 2E1, Canada, and.
6
Department of Human Development, Cornell University, Ithaca, New York 1485.

Abstract

Emotionally salient aspects of the world are experienced with greater perceptual vividness than mundane ones; however, such emotionally enhanced vividness (EEV) may be experienced to different degrees for different people. We examined whether BOLD activity associated with a deletion variant of the ADRA2b gene coding for the α2b adrenoceptor modulates EEV in humans. Relative to noncarriers, ADRA2b deletion carriers showed higher levels of perceptual vividness, with the ventromedial prefrontal cortex (VMPFC) showing greater modulation by EEV. Deletion carriers were also more sensitive to the featural salience of the images, suggesting a more pervasive role of norepinephrine in perceptual encoding. Path analysis revealed that, whereas a simple model by which the amygdala modulated the lateral occipital complex best characterized EEV-related activity in noncarriers, contributions of an additional VMPFC pathway best characterized deletion carriers. Thus, common norepinephrine-related neurogenetic differences enhance the subjective vividness of perceptual experience and its emotional enhancement.

KEYWORDS:

ADRA2b; attention; emotion; emotionally enhanced vividness; fMRI; neurogenetics

PMID:
25904801
DOI:
10.1523/JNEUROSCI.4489-14.2015
[Indexed for MEDLINE]
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