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Transl Psychiatry. 2013 Dec 3;3:e329. doi: 10.1038/tp.2013.108.

Neurodevelopmental disorders: mechanisms and boundary definitions from genomes, interactomes and proteomes.

Author information

1
Department of Cell Biology, Emory University School of Medicine, Center for Social Translational Neuroscience, Emory University, Atlanta, GA, USA.

Abstract

Neurodevelopmental disorders such as intellectual disability, autism spectrum disorder and schizophrenia lack precise boundaries in their clinical definitions, epidemiology, genetics and protein-protein interactomes. This calls into question the appropriateness of current categorical disease concepts. Recently, there has been a rising tide to reformulate neurodevelopmental nosological entities from biology upward. To facilitate this developing trend, we propose that identification of unique proteomic signatures that can be strongly associated with patient's risk alleles and proteome-interactome-guided exploration of patient genomes could define biological mechanisms necessary to reformulate disorder definitions.

PMID:
24301647
PMCID:
PMC4030327
DOI:
10.1038/tp.2013.108
[Indexed for MEDLINE]
Free PMC Article

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