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Neurosci Biobehav Rev. 2017 Mar;74(Pt A):21-43. doi: 10.1016/j.neubiorev.2017.01.005. Epub 2017 Jan 11.

Neurobiological consequences of juvenile stress: A GABAergic perspective on risk and resilience.

Author information

1
Sagol Department of Neurobiology, University of Haifa, 199 Aba-Hushi Avenue, 3498838 Haifa, Israel; The Institute for the Study of Affective Neuroscience (ISAN), 199 Aba-Hushi Avenue, 3498838 Haifa, Israel; Department of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany. Electronic address: anne1.albrecht@ovgu.de.
2
Department of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.
3
Sagol Department of Neurobiology, University of Haifa, 199 Aba-Hushi Avenue, 3498838 Haifa, Israel.
4
Department of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany; Neuroscience Research Center, Charité University Hospital Berlin, Hufelandweg 14, 10117 Berlin, Germany.
5
Neuroscience Research Center, Charité University Hospital Berlin, Hufelandweg 14, 10117 Berlin, Germany.
6
Department of Neurobiology, The Weizmann Institute, Herzl St 234, 7610001 Rehovot, Israel.
7
Research Department of Experimental and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Charité University Hospital Berlin, Garystraße 5, 14195 Berlin, Germany; Department of Psychiatry, Psychotherapy and Psychosomatic, Brandenburg Medical School - Campus Neuruppin, Fehrbelliner Straße 38, 16816 Neuruppin, Germany.
8
Department of Genetics & Molecular Neurobiology, Institute of Biology, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany; Center for Behavioral Brain Sciences, Universitätsplatz 2, 39106 Magdeburg, Germany.
9
Sagol Department of Neurobiology, University of Haifa, 199 Aba-Hushi Avenue, 3498838 Haifa, Israel; The Institute for the Study of Affective Neuroscience (ISAN), 199 Aba-Hushi Avenue, 3498838 Haifa, Israel; Department of Psychology, University of Haifa, 199 Aba-Hushi Avenue, 3498838 Haifa, Israel.

Abstract

ALBRECHT, A., MÜLLER, I., ARDI, Z., ÇALIŞKAN, G., GRUBER, D., IVENS, S., SEGAL, M., BEHR, J., HEINEMANN, U., STORK, O., and RICHTER-LEVIN, G. Neurobiological consequences of juvenile stress: A GABAergic perspective on risk and resilience. NEUROSCI BIOBEHAV REV XXX-XXX, 2016.- Childhood adversity is among the most potent risk factors for developing mood and anxiety disorders later in life. Therefore, understanding how stress during childhood shapes and rewires the brain may optimize preventive and therapeutic strategies for these disorders. To this end, animal models of stress exposure in rodents during their post-weaning and pre-pubertal life phase have been developed. Such 'juvenile stress' has a long-lasting impact on mood and anxiety-like behavior and on stress coping in adulthood, accompanied by alterations of the GABAergic system within core regions for the stress processing such as the amygdala, prefrontal cortex and hippocampus. While many regionally diverse molecular and electrophysiological changes are observed, not all of them correlate with juvenile stress-induced behavioral disturbances. It rather seems that certain juvenile stress-induced alterations reflect the system's attempts to maintain homeostasis and thus promote stress resilience. Analysis tools such as individual behavioral profiling may allow the association of behavioral and neurobiological alterations more clearly and the dissection of alterations related to the pathology from those related to resilience.

KEYWORDS:

Anxiety; Behavioral profiling; Corticosterone; Dentate gyrus; Dorsal and ventral hippocampus; GABAergic system; HPA axis; Juvenile stress; Posttraumatic stress disorder; Resilience

PMID:
28088535
DOI:
10.1016/j.neubiorev.2017.01.005
[Indexed for MEDLINE]

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