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Wiley Interdiscip Rev Syst Biol Med. 2013 Nov-Dec;5(6):701-15. doi: 10.1002/wsbm.1239. Epub 2013 Sep 20.

Neural stem and progenitor cells in health and disease.

Author information

1
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA.

Abstract

Neural stem/progenitor cells (NSPCs) have the potential to differentiate into neurons, astrocytes, and/or oligodendrocytes. Because these cells can be expanded in culture, they represent a vast source of neural cells. With the recent discovery that patient fibroblasts can be reprogrammed directly into induced NSPCs, the regulation of NSPC fate and function, in the context of cell-based disease models and patient-specific cell-replacement therapies, warrants review.

PMID:
24068527
PMCID:
PMC4160040
DOI:
10.1002/wsbm.1239
[Indexed for MEDLINE]
Free PMC Article

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