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Nanomedicine (Lond). 2017 Feb;12(4):317-331. doi: 10.2217/nnm-2016-0319. Epub 2017 Jan 12.

Nanovesicle delivery to the liver via retinol binding protein and platelet-derived growth factor receptors: how targeting ligands affect biodistribution.

Author information

1
Department of Nutrition & Health Sciences, Chang Gung University of Science & Technology, Kweishan, Taoyuan, Taiwan.
2
Research Center for Chinese Herbal Medicine & Research Center for Food and Cosmetic Safety, Chang Gung University of Science & Technology, Kweishan, Taoyuan, Taiwan.
3
Division of General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan.
4
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
5
Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan.
6
Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Kweishan, Taoyuan, Taiwan.
7
Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan.

Abstract

AIM:

Nanovesicles (NVs) conjugating ligands can deliver to the specific nidus. We designed a nanosystem targeting the injectable niosomes to liver for examining biodistribution.

METHODOLOGY:

Vitamin A and antiplatelet-derived growth factor receptor antibody were employed as the ligands to be taken by hepatic stellate cells. The biodistribution in rats was visualized by bioimaging.

RESULTS:

A significant liver accumulation was detected for antibody-embedded NVs at 2 h after dosing. The vitamin A embedded NVs exhibited a delayed targeting to the liver (5 h). The spleen, intestine and kidneys were the nontargeted organs where the vitamin A loaded niosomes largely accumulated. The antibody-loaded NVs could deliver to the spleen, kidneys and lungs. The antibody-loaded nanocarriers increased silibinin uptake to lungs by fourfold than the plain NVs.

CONCLUSION:

The results have practical application for better designing of active targeting nanocarriers.

KEYWORDS:

antibody; biodistribution; liver; nanovesicle; niosome; vitamin A

PMID:
28078954
DOI:
10.2217/nnm-2016-0319
[Indexed for MEDLINE]

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