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Rep Pract Oncol Radiother. 2018 Sep-Oct;23(5):474-480. doi: 10.1016/j.rpor.2018.08.001. Epub 2018 Sep 6.

Nanoparticles and nanothermia for malignant brain tumors, a suggestion of treatment for further investigations.

Author information

1
Radiation Oncology Department, University Hospital San Cecilio, Av. Dr. Olóriz 16, 18012 Granada, Spain.
2
Radiation Oncology Department, Institut Català d'Oncologia, Avinguda Granvia, 199-203, 08908, L'Hospitalet de Llobregat, Barcelona, Spain.

Abstract

The current treatment for brain tumors, such as glioblastoma multiforme (GBM), has not been developed enough yet in order to fully heal them. The main causes are the lack of specificity of the treatments, the difficulty of passage of drugs through the blood-brain barrier, heterogeneity and tumor aggressiveness, and widespread dissemination in the brain. The application of nanoparticles (Nps) have been a breakthrough for both diagnostic imaging and targeted therapies. There have been numerous studies with different types of Nps in brain tumors, but we have focused on thermosensitive liposomes, which are characterized by releasing the chemotherapeutic agent included within its lipophilic membranes through heat. Furthermore, increasing the temperature in brain tumors through hyperthermia has been proven therapeutically beneficial. Nanothermia or modulated-electro-hyperthermia (MEHT) is an improved technique that allows to create hot spots in nanorange at the membrane rafts, specifically in tumor cells, theoretically increasing the selectivity of the damage. In scientific records, experiments that combine both techniques (thermosensitive liposomes and nanothermia) have never been conducted. We propose a hypothesis for further research.

KEYWORDS:

GBM; Liposomes; MEHT; Nanoparticles; Termosensitive

PMID:
30263017
PMCID:
PMC6158037
[Available on 2019-09-01]
DOI:
10.1016/j.rpor.2018.08.001

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