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Page 1
Anti-seizure effect and neuronal activity change in the genetic-epileptic model rat with acute and chronic vagus nerve stimulation.
Katagiri M, Iida K, Ishihara K, Nair D, Harada K, Kagawa K, Seyama G, Hashizume A, Kuramoto T, Hanaya R, Arita K, Kurisu K. Katagiri M, et al. Epilepsy Res. 2019 Sep;155:106159. doi: 10.1016/j.eplepsyres.2019.106159. Epub 2019 Jul 2. Epilepsy Res. 2019. PMID: 31277035
We carried out double immunofluorescence for biomarkers of short-term (c-Fos) and long-term (deltaFosB) neuronal activation to map regions in the brain that were activated by acute (VNS n = 6, control n = 6) or chronic VNS (VNS n = 5, control n = 5). F …
We carried out double immunofluorescence for biomarkers of short-term (c-Fos) and long-term (deltaFosB) neuronal activation to map regions i …
Psychological flexibility, distress, and quality of life in secondary progressive multiple sclerosis: A cross-sectional study.
Meek C, das Nair R, Evangelou N, Middleton R, Tuite-Dalton K, Moghaddam N. Meek C, et al. Mult Scler Relat Disord. 2022 Nov;67:104154. doi: 10.1016/j.msard.2022.104154. Epub 2022 Aug 29. Mult Scler Relat Disord. 2022. PMID: 36116384
Psychological flexibility (M = 81.94, SD = 22.60) and its components were each moderately negatively correlated with total distress (r = -0.65), anxiety (r = -0.58), and depression (r = -0.56). A second subsample (n = 434) completed the EQ-5D-5L health-related quali …
Psychological flexibility (M = 81.94, SD = 22.60) and its components were each moderately negatively correlated with total distress (r = -0. …
Computational, crystallographic studies, cytotoxicity and anti-tubercular activity of substituted 7-methoxy-indolizine analogues.
Venugopala KN, Chandrashekharappa S, Pillay M, Abdallah HH, Mahomoodally FM, Bhandary S, Chopra D, Attimarad M, Aldhubiab BE, Nair AB, Sreeharsha N, Morsy MA, Pottathil S, Venugopala R, Odhav B, Mlisana K. Venugopala KN, et al. PLoS One. 2019 Jun 4;14(6):e0217270. doi: 10.1371/journal.pone.0217270. eCollection 2019. PLoS One. 2019. PMID: 31163040 Free PMC article.
MD simulation showed that 5j possessed the highest binding affinity toward the enzyme, according to the two calculation methods (MM/PBSA and MM/GBSA). The single-crystal X-ray studies of compounds 5c and 5d revealed that the molecular arrangements in these two structures w …
MD simulation showed that 5j possessed the highest binding affinity toward the enzyme, according to the two calculation methods (MM/PBSA and …
Association between glycated hemoglobin and health utility for Type 1 diabetes.
McQueen RB, Ellis SL, Maahs DM, Anderson HD, Nair KV, Libby AM, Campbell JD. McQueen RB, et al. Patient. 2014;7(2):197-205. doi: 10.1007/s40271-014-0045-4. Patient. 2014. PMID: 24458545
Health utility scores were derived using the US time-tradeoff valuation of the EQ-5D. Linear regression was used to estimate the relationship between HbA1c and utility, adjusting for treatments, demographics, and diabetes-related complications. ...Unadjusted mean (SD) util …
Health utility scores were derived using the US time-tradeoff valuation of the EQ-5D. Linear regression was used to estimate the rela …
Renal and Hepatic Outcomes after Remdesivir Therapy in Coronavirus Disease-2019-Positive Patients with Renal Dysfunction at Baseline or after Starting Therapy.
Shakir A, Bhasin N, Swami R, Mehta K, Sinha S, Ali SS, Bansode J. Shakir A, et al. Saudi J Kidney Dis Transpl. 2021 Jul-Aug;32(4):1034-1042. doi: 10.4103/1319-2442.338277. Saudi J Kidney Dis Transpl. 2021. PMID: 35229803
Thirty-four patients had renal dysfunction at baseline or developed it after remdesivir therapy - 16 were acute kidney injury (AKI), 10 chronic kidney diseases (CKD), four CKD stage 5D, and four were postrenal transplant. The overall mortality was 18/34 (52.9%). Eight out …
Thirty-four patients had renal dysfunction at baseline or developed it after remdesivir therapy - 16 were acute kidney injury (AKI), 10 chro …
Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women.
González F, Nair KS, Daniels JK, Basal E, Schimke JM, Blair HE. González F, et al. J Clin Endocrinol Metab. 2012 Aug;97(8):2836-43. doi: 10.1210/jc.2012-1259. Epub 2012 May 8. J Clin Endocrinol Metab. 2012. PMID: 22569241 Free PMC article. Clinical Trial.
PARTICIPANTS, DESIGN, AND SETTING: Sixteen lean healthy ovulatory reproductive-age women were treated with 130 mg dehydroepiandrosterone (DHEA) or placebo (n = 8 each) for 5 d in this randomized, controlled, double-blind study that was performed at an an academic medical c …
PARTICIPANTS, DESIGN, AND SETTING: Sixteen lean healthy ovulatory reproductive-age women were treated with 130 mg dehydroepiandrosterone (DH …
Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity.
Wang Y, Botolin D, Xu J, Christian B, Mitchell E, Jayaprakasam B, Nair MG, Peters JM, Busik JV, Olson LK, Jump DB. Wang Y, et al. J Lipid Res. 2006 Sep;47(9):2028-41. doi: 10.1194/jlr.M600177-JLR200. Epub 2006 Jun 21. J Lipid Res. 2006. PMID: 16790840 Free PMC article.
In leptin-deficient obese mice (Lep(ob/ob)), increased SREBP-1 and MLX nuclear content correlated with the induction of Elovl-5, Elovl-6, and Delta(9)D expression and the massive accumulation of monounsaturated fatty acids (18:1,n-7 and 18:1,n-9) in neutral lipids. …
In leptin-deficient obese mice (Lep(ob/ob)), increased SREBP-1 and MLX nuclear content correlated with the induction of Elovl-5, Elovl-6, an …
Nitroimidazoles, Part XXIII--activity of satranidazole series against anaerobic infections.
Nagarajan K, Gowrishankar R, Arya VP, George T, Nair MD, Shenoy SJ, Sudarsanam V. Nagarajan K, et al. Indian J Exp Biol. 1992 Mar;30(3):193-200. Indian J Exp Biol. 1992. PMID: 1512026
Among these may be mentioned 1-methyl-5-nitroimidazoles carrying N - bound hetetocycles at position 2, such as satranidazole 1a, 1b, 1c, 1k, 1n and 1v which are at least twice as active as metronidazole (16a), ornidazole (16b) and tinidazole (16c). Even more active are 5-n …
Among these may be mentioned 1-methyl-5-nitroimidazoles carrying N - bound hetetocycles at position 2, such as satranidazole 1a, 1b, …