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Nomo1 deficiency causes autism-like behavior in zebrafish.
Zhang Q, Li F, Li T, Lin J, Jian J, Zhang Y, Chen X, Liu T, Gou S, Zhang Y, Liu X, Ji Y, Wang X, Li Q. Zhang Q, et al. EMBO Rep. 2024 Feb;25(2):570-592. doi: 10.1038/s44319-023-00036-y. Epub 2024 Jan 22. EMBO Rep. 2024. PMID: 38253686 Free PMC article.
Here, we generate nomo1(-/-) zebrafish to get further insight into the function of NOMO1. Nomo1 mutants show abnormal brain and neuronal development and activation of apoptosis and inflammation-related pathways in the brain. ...
Here, we generate nomo1(-/-) zebrafish to get further insight into the function of NOMO1. Nomo1 mutants show abnormal b …
Establishment of a conditional Nomo1 mouse model by CRISPR/Cas9 technology.
García-Tuñón I, Vuelta E, Lozano L, Herrero M, Méndez L, Palomero-Hernandez J, Pérez-Caro M, Pérez-García J, González-Sarmiento R, Sánchez-Martín M. García-Tuñón I, et al. Mol Biol Rep. 2020 Feb;47(2):1381-1391. doi: 10.1007/s11033-019-05214-7. Epub 2019 Dec 12. Mol Biol Rep. 2020. PMID: 31833031
To extend our understanding of Nomo1 function in postnatal stages and in a tissue-specific manner, we generated a conditional knockout mouse model of Nomo1. ...Genomic and expression studies in Nomo1-transduced MEFs demonstrated that the Nomo1 exon 3 i …
To extend our understanding of Nomo1 function in postnatal stages and in a tissue-specific manner, we generated a conditional knockou …
Recurrent NOMO1 Gene Deletion Is a Potential Clinical Marker in Early-Onset Colorectal Cancer and Is Involved in the Regulation of Cell Migration.
Pérez-García J, Martel-Martel A, García-Vallés P, Corchete LA, García JL, Gestoso-Uzal N, Vidal-Tocino R, Blanco Ó, Méndez L, Sánchez-Martín M, Fuentes M, Herrero AB, Holowatyj AN, Perea J, González-Sarmiento R. Pérez-García J, et al. Cancers (Basel). 2022 Aug 20;14(16):4029. doi: 10.3390/cancers14164029. Cancers (Basel). 2022. PMID: 36011023 Free PMC article.
To study the role of NOMO1 in EOCRC, CRISPR/cas9 technology was employed to generate NOMO1 knockout HCT-116 (EOCRC) and HS-5 (bone marrow) cell lines. ...Significantly, NOMO1 loss increased the migration capacity of CRC cells. Additionally, a gut-specific con …
To study the role of NOMO1 in EOCRC, CRISPR/cas9 technology was employed to generate NOMO1 knockout HCT-116 (EOCRC) and HS-5 ( …
MRTFB regulates the expression of NOMO1 in colon.
Zhao T, Hu Y, Zang T, Cheng L. Zhao T, et al. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7568-7569. doi: 10.1073/pnas.2000499117. Epub 2020 Mar 17. Proc Natl Acad Sci U S A. 2020. PMID: 32184333 Free PMC article. No abstract available.
MiR-33a-5p targets NOMO1 to modulate human cardiomyocyte progenitor cells proliferation and differentiation and apoptosis.
Xing W, Li T, Wang Y, Qiang Y, Ai C, Tang H. Xing W, et al. J Recept Signal Transduct Res. 2021 Oct;41(5):476-487. doi: 10.1080/10799893.2020.1825492. Epub 2020 Oct 14. J Recept Signal Transduct Res. 2021. PMID: 33054489
PURPOSE: MicroRNA (miRNA) is known to be involved in the pathological process of congenital heart disease (CHD), and nodal modulator1 (NOMO1) is a critical determinant of heart formation. The present study aims to discover the effect of miR-33a-5p and NOMO1 on CHD. …
PURPOSE: MicroRNA (miRNA) is known to be involved in the pathological process of congenital heart disease (CHD), and nodal modulator1 (NO …
Reply to Zhao et al.: NOMO1 is a potential target gene of MRTFB.
Marian TA, Wei Z. Marian TA, et al. Proc Natl Acad Sci U S A. 2020 Apr 7;117(14):7570-7571. doi: 10.1073/pnas.2000772117. Epub 2020 Mar 17. Proc Natl Acad Sci U S A. 2020. PMID: 32184332 Free PMC article. No abstract available.
NOMO-1 gene is deleted in early-onset colorectal cancer.
Perea J, García JL, Pérez J, Rueda D, Arriba M, Rodríguez Y, Urioste M, González-Sarmiento R. Perea J, et al. Oncotarget. 2017 Apr 11;8(15):24429-24436. doi: 10.18632/oncotarget.15478. Oncotarget. 2017. PMID: 28416736 Free PMC article.
Within the primary EOCRC population, 34 out of 34 of tumours showed a homozygous deletion in NOMO1, while in the late-onset population only 2 of the 17 tumours (11.7%) showed it. ...Deletion of NOMO1 is a molecular marker predominantly associated with EOCRC, particu …
Within the primary EOCRC population, 34 out of 34 of tumours showed a homozygous deletion in NOMO1, while in the late-onset populatio …
Nodal modulator (NOMO) is required to sustain endoplasmic reticulum morphology.
Amaya C, Cameron CJF, Devarkar SC, Seager SJH, Gerstein MB, Xiong Y, Schlieker C. Amaya C, et al. J Biol Chem. 2021 Aug;297(2):100937. doi: 10.1016/j.jbc.2021.100937. Epub 2021 Jul 3. J Biol Chem. 2021. PMID: 34224731 Free PMC article.
Extending NOMO1 by insertion of additional immunoglobulin folds results in a correlative increase in the ER intermembrane distance. Based on these observations and a genetic epistasis analysis including the known ER-shaping proteins Atlastin2 and Climp63, we propose a role …
Extending NOMO1 by insertion of additional immunoglobulin folds results in a correlative increase in the ER intermembrane distance. B …
Silencing of nodal modulator 1 inhibits the differentiation of P19 cells into cardiomyocytes.
Zhang H, Xu C, Yang R, Chen H, Kong X, Qian L, Sheng Y, Sun W. Zhang H, et al. Exp Cell Res. 2015 Feb 15;331(2):369-76. doi: 10.1016/j.yexcr.2014.12.016. Epub 2015 Jan 6. Exp Cell Res. 2015. PMID: 25576386
In this study, we aimed to investigate the effects of NOMO1 gene silencing by RNA interference (RNAi) during early mouse cardiac differentiation using P19 cells as a model system. ...Similarly, cardiomyocyte-specific sarcomeric markers, such as cardiac troponin T, as well …
In this study, we aimed to investigate the effects of NOMO1 gene silencing by RNA interference (RNAi) during early mouse cardiac diff …
The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1 (NOMO1).
Gao WL, Liu M, Yang Y, Yang H, Liao Q, Bai Y, Li YX, Li D, Peng C, Wang YL. Gao WL, et al. RNA Biol. 2012 Jul;9(7):1002-10. doi: 10.4161/rna.20807. Epub 2012 Jul 1. RNA Biol. 2012. PMID: 22832245
Target gene prediction in combination with luciferase assay revealed that miR-675 could directly downregulate Nodal Modulator 1 (NOMO1) protein expression by binding to 3'-UTR sequence of NOMO1. ...In early-onset preeclamptic placentas, expression levels of H19 gene …
Target gene prediction in combination with luciferase assay revealed that miR-675 could directly downregulate Nodal Modulator 1 (NOMO1 …
46 results