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See also: NGLY1 N-glycanase 1 in the Gene database

ngly1 in Homo sapiensMus musculusRattus norvegicusAll 272 Gene records

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Items: 1 to 20 of 35

1.

Generation of an induced pluripotent stem cell line (TRNDi002-B) from a patient carrying compound heterozygous p.Q208X and p.G310G mutations in the NGLY1 gene.

Li R, Pradhan M, Xu M, Baskfield A, Farkhondeh A, Cheng YS, Beers J, Zou J, Liu C, Might M, Rodems S, Zheng W.

Stem Cell Res. 2018 Dec 5;34:101362. doi: 10.1016/j.scr.2018.101362. [Epub ahead of print]

2.

Serum starvation raises turnover of phosphorylated p62/SQSTM1 (Serine 349), reveals expression of proteasome and N-glycanase1 interactive protein RAD23B and sensitizes human synovial fibroblasts to BAY 11-7085-induced cell death.

Relic B, Charlier E, Deroyer C, Malaise O, Crine Y, Neuville S, Gillet P, de Seny D, Malaise MG.

Oncotarget. 2018 Nov 9;9(88):35830-35843. doi: 10.18632/oncotarget.26295. eCollection 2018 Nov 9.

3.

Stress and interferon signalling-mediated apoptosis contributes to pleiotropic anticancer responses induced by targeting NGLY1.

Zolekar A, Lin VJT, Mishra NM, Ho YY, Hayatshahi HS, Parab A, Sampat R, Liao X, Hoffmann P, Liu J, Emmitte KA, Wang YC.

Br J Cancer. 2018 Dec;119(12):1538-1551. doi: 10.1038/s41416-018-0265-9. Epub 2018 Nov 2.

PMID:
30385822
4.

N-glycanase NGLY1 regulates mitochondrial homeostasis and inflammation through NRF1.

Yang K, Huang R, Fujihira H, Suzuki T, Yan N.

J Exp Med. 2018 Oct 1;215(10):2600-2616. doi: 10.1084/jem.20180783. Epub 2018 Aug 22.

PMID:
30135079
5.

Defects in the Neuroendocrine Axis Contribute to Global Development Delay in a Drosophila Model of NGLY1 Deficiency.

Rodriguez TP, Mast JD, Hartl T, Lee T, Sand P, Perlstein EO.

G3 (Bethesda). 2018 Jul 2;8(7):2193-2204. doi: 10.1534/g3.118.300578. Erratum in: G3 (Bethesda). 2019 Jan 9;9(1):315.

6.

Urine oligosaccharide screening by MALDI-TOF for the identification of NGLY1 deficiency.

Hall PL, Lam C, Alexander JJ, Asif G, Berry GT, Ferreira C, Freeze HH, Gahl WA, Nickander KK, Sharer JD, Watson CM, Wolfe L, Raymond KM.

Mol Genet Metab. 2018 May;124(1):82-86. doi: 10.1016/j.ymgme.2018.03.002. Epub 2018 Mar 10.

PMID:
29550355
7.

NGLY1-Related Congenital Disorder of Deglycosylation.

Lam C, Wolfe L, Need A, Shashi V, Enns G.

In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2019.
2018 Feb 8.

8.

Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approaches.

Owings KG, Lowry JB, Bi Y, Might M, Chow CY.

Hum Mol Genet. 2018 Mar 15;27(6):1055-1066. doi: 10.1093/hmg/ddy026.

PMID:
29346549
9.

A New Fluorogenic Probe for the Detection of endo-β-N-Acetylglucosaminidase.

Ishii N, Sunaga C, Sano K, Huang C, Iino K, Matsuzaki Y, Suzuki T, Matsuo I.

Chembiochem. 2018 Apr 4;19(7):660-663. doi: 10.1002/cbic.201700662. Epub 2018 Feb 16.

PMID:
29323460
10.

Inhibition of NGLY1 Inactivates the Transcription Factor Nrf1 and Potentiates Proteasome Inhibitor Cytotoxicity.

Tomlin FM, Gerling-Driessen UIM, Liu YC, Flynn RA, Vangala JR, Lentz CS, Clauder-Muenster S, Jakob P, Mueller WF, Ordoñez-Rueda D, Paulsen M, Matsui N, Foley D, Rafalko A, Suzuki T, Bogyo M, Steinmetz LM, Radhakrishnan SK, Bertozzi CR.

ACS Cent Sci. 2017 Nov 22;3(11):1143-1155. doi: 10.1021/acscentsci.7b00224. Epub 2017 Oct 25.

11.

Enzymatic insights into an inherited genetic disorder.

Zhang L, Ten Hagen KG.

Elife. 2017 Sep 14;6. pii: e31127. doi: 10.7554/eLife.31127.

12.

Tissue-specific regulation of BMP signaling by Drosophila N-glycanase 1.

Galeone A, Han SY, Huang C, Hosomi A, Suzuki T, Jafar-Nejad H.

Elife. 2017 Aug 4;6. pii: e27612. doi: 10.7554/eLife.27612.

13.

Mitochondrial function requires NGLY1.

Kong J, Peng M, Ostrovsky J, Kwon YJ, Oretsky O, McCormick EM, He M, Argon Y, Falk MJ.

Mitochondrion. 2018 Jan;38:6-16. doi: 10.1016/j.mito.2017.07.008. Epub 2017 Jul 25.

14.

Repurposing of Proton Pump Inhibitors as first identified small molecule inhibitors of endo-β-N-acetylglucosaminidase (ENGase) for the treatment of NGLY1 deficiency, a rare genetic disease.

Bi Y, Might M, Vankayalapati H, Kuberan B.

Bioorg Med Chem Lett. 2017 Jul 1;27(13):2962-2966. doi: 10.1016/j.bmcl.2017.05.010. Epub 2017 May 5.

15.

Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene.

Fujihira H, Masahara-Negishi Y, Tamura M, Huang C, Harada Y, Wakana S, Takakura D, Kawasaki N, Taniguchi N, Kondoh G, Yamashita T, Funakoshi Y, Suzuki T.

PLoS Genet. 2017 Apr 20;13(4):e1006696. doi: 10.1371/journal.pgen.1006696. eCollection 2017 Apr.

16.

Providing Palliative Care in Rare Pediatric Diseases: A Case Series of Three Children with Congenital Disorder of Glycosylation.

Trowbridge A, Stewart MT, Rhee E, Hwang JM.

J Palliat Med. 2017 Jan;20(1):104-106. Epub 2016 Dec 6.

PMID:
27923105
17.

What happens when N = 1 and you want plus 1?

Might M, Might CC.

Prenat Diagn. 2017 Jan;37(1):70-72. doi: 10.1002/pd.4975. Epub 2016 Dec 30.

PMID:
27885678
18.

Human genome-wide RNAi screen reveals host factors required for enterovirus 71 replication.

Wu KX, Phuektes P, Kumar P, Goh GY, Moreau D, Chow VT, Bard F, Chu JJ.

Nat Commun. 2016 Oct 17;7:13150. doi: 10.1038/ncomms13150.

19.

Novel small molecule binders of human N-glycanase 1, a key player in the endoplasmic reticulum associated degradation pathway.

Srinivasan B, Zhou H, Mitra S, Skolnick J.

Bioorg Med Chem. 2016 Oct 1;24(19):4750-4758. doi: 10.1016/j.bmc.2016.08.019. Epub 2016 Aug 13.

20.

Prospective phenotyping of NGLY1-CDDG, the first congenital disorder of deglycosylation.

Lam C, Ferreira C, Krasnewich D, Toro C, Latham L, Zein WM, Lehky T, Brewer C, Baker EH, Thurm A, Farmer CA, Rosenzweig SD, Lyons JJ, Schreiber JM, Gropman A, Lingala S, Ghany MG, Solomon B, Macnamara E, Davids M, Stratakis CA, Kimonis V, Gahl WA, Wolfe L.

Genet Med. 2017 Feb;19(2):160-168. doi: 10.1038/gim.2016.75. Epub 2016 Jul 7.

PMID:
27388694

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