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Curr Opin Immunol. 2000 Feb;12(1):52-8.

NF-kappaB and the innate immune response.

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Max-Delbrück-Center for Molecular Medicine, Berlin, 13122, Germany.


In the innate immune reaction, microbial pathogens activate phylogenetically conserved cellular signal transduction pathways that regulate the ubiquitous nuclear factor-kappaB (NFkappaB). NF-kappaB has pleiotropic functions in immunity; however, it is also critical for development and cellular survival. Many aspects of how the different pathways utilize a common kinase complex that ultimately activates NF-kappaB have been clarified by gene inactivation and biochemical analysis.

[Indexed for MEDLINE]

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