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Items: 1 to 20 of 31


Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.

Kim YS, Gupta Vallur P, Jones VM, Worley BL, Shimko S, Shin DH, Crawford LC, Chen CW, Aird KM, Abraham T, Shepherd TG, Warrick JI, Lee NY, Phaeton R, Mythreye K, Hempel N.

Oncogene. 2019 Nov 13. doi: 10.1038/s41388-019-1097-7. [Epub ahead of print]


GPx3 supports ovarian cancer progression by manipulating the extracellular redox environment.

Worley BL, Kim YS, Mardini J, Zaman R, Leon KE, Vallur PG, Nduwumwami A, Warrick JI, Timmins PF, Kesterson JP, Phaëton R, Lee NY, Walter V, Endres L, Mythreye K, Aird KM, Hempel N.

Redox Biol. 2019 Jul;25:101051. doi: 10.1016/j.redox.2018.11.009. Epub 2018 Nov 17.


Deoxycholate Fractionation of Fibronectin (FN) and Biotinylation Assay to Measure Recycled FN Fibrils in Epithelial Cells.

Varadaraj A, Magdaleno C, Mythreye K.

Bio Protoc. 2018 Aug 20;8(16). pii: e2972. doi: 10.21769/BioProtoc.2972.


CDK8 Selectively Promotes the Growth of Colon Cancer Metastases in the Liver by Regulating Gene Expression of TIMP3 and Matrix Metalloproteinases.

Liang J, Chen M, Hughes D, Chumanevich AA, Altilia S, Kaza V, Lim CU, Kiaris H, Mythreye K, Pena MM, Broude EV, Roninson IB.

Cancer Res. 2018 Dec 1;78(23):6594-6606. doi: 10.1158/0008-5472.CAN-18-1583. Epub 2018 Sep 5.


Mediator kinase CDK8/CDK19 drives YAP1-dependent BMP4-induced EMT in cancer.

Serrao A, Jenkins LM, Chumanevich AA, Horst B, Liang J, Gatza ML, Lee NY, Roninson IB, Broude EV, Mythreye K.

Oncogene. 2018 Aug;37(35):4792-4808. doi: 10.1038/s41388-018-0316-y. Epub 2018 May 21.


TAK1 activation of alpha-TAT1 and microtubule hyperacetylation control AKT signaling and cell growth.

Shah N, Kumar S, Zaman N, Pan CC, Bloodworth JC, Lei W, Streicher JM, Hempel N, Mythreye K, Lee NY.

Nat Commun. 2018 Apr 27;9(1):1696. doi: 10.1038/s41467-018-04121-y.


Inhibin Is a Novel Paracrine Factor for Tumor Angiogenesis and Metastasis.

Singh P, Jenkins LM, Horst B, Alers V, Pradhan S, Kaur P, Srivastava T, Hempel N, Győrffy B, Broude EV, Lee NY, Mythreye K.

Cancer Res. 2018 Jun 1;78(11):2978-2989. doi: 10.1158/0008-5472.CAN-17-2316. Epub 2018 Mar 13.


Dually modified transmembrane proteoglycans in development and disease.

Jenkins LM, Horst B, Lancaster CL, Mythreye K.

Cytokine Growth Factor Rev. 2018 Feb;39:124-136. doi: 10.1016/j.cytogfr.2017.12.003. Epub 2017 Dec 22. Review.


Insights into the Dichotomous Regulation of SOD2 in Cancer.

Kim YS, Gupta Vallur P, Phaëton R, Mythreye K, Hempel N.

Antioxidants (Basel). 2017 Nov 3;6(4). pii: E86. doi: 10.3390/antiox6040086. Review.


TGF-β triggers rapid fibrillogenesis via a novel TβRII-dependent fibronectin-trafficking mechanism.

Varadaraj A, Jenkins LM, Singh P, Chanda A, Snider J, Lee NY, Amsalem-Zafran AR, Ehrlich M, Henis YI, Mythreye K.

Mol Biol Cell. 2017 May 1;28(9):1195-1207. doi: 10.1091/mbc.E16-08-0601. Epub 2017 Mar 15.


Altering the Proteoglycan State of Transforming Growth Factor β Type III Receptor (TβRIII)/Betaglycan Modulates Canonical Wnt/β-Catenin Signaling.

Jenkins LM, Singh P, Varadaraj A, Lee NY, Shah S, Flores HV, O'Connell K, Mythreye K.

J Biol Chem. 2016 Dec 2;291(49):25716-25728. Epub 2016 Oct 26.


Activation of Mitofusin2 by Smad2-RIN1 Complex during Mitochondrial Fusion.

Kumar S, Pan CC, Shah N, Wheeler SE, Hoyt KR, Hempel N, Mythreye K, Lee NY.

Mol Cell. 2016 May 19;62(4):520-31. doi: 10.1016/j.molcel.2016.04.010. Epub 2016 May 12.


Angiostatic actions of capsicodendrin through selective inhibition of VEGFR2-mediated AKT signaling and disregulated autophagy.

Pan CC, Shah N, Kumar S, Wheeler SE, Cinti J, Hoyt DG, Beattie CE, An M, Mythreye K, Rakotondraibe LH, Lee NY.

Oncotarget. 2017 Feb 21;8(8):12675-12685. doi: 10.18632/oncotarget.9307.


Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia.

Varadaraj A, Patel P, Serrao A, Bandyopadhay T, Lee NY, Jazaeri AA, Huang Z, Murphy SK, Mythreye K.

Neoplasia. 2015 Nov;17(11):826-38. doi: 10.1016/j.neo.2015.11.003.


Endoglin Regulation of Smad2 Function Mediates Beclin1 Expression and Endothelial Autophagy.

Pan CC, Kumar S, Shah N, Bloodworth JC, Hawinkels LJ, Mythreye K, Hoyt DG, Lee NY.

J Biol Chem. 2015 Jun 12;290(24):14884-92. doi: 10.1074/jbc.M114.630178. Epub 2015 Apr 30.


TGF-β regulates LARG and GEF-H1 during EMT to affect stiffening response to force and cell invasion.

Osborne LD, Li GZ, How T, O'Brien ET, Blobe GC, Superfine R, Mythreye K.

Mol Biol Cell. 2014 Nov 5;25(22):3528-40. doi: 10.1091/mbc.E14-05-1015. Epub 2014 Aug 20.


Src-mediated post-translational regulation of endoglin stability and function is critical for angiogenesis.

Pan CC, Kumar S, Shah N, Hoyt DG, Hawinkels LJ, Mythreye K, Lee NY.

J Biol Chem. 2014 Sep 12;289(37):25486-96. doi: 10.1074/jbc.M114.578609. Epub 2014 Jul 28.


Type III TGF-β receptor promotes FGF2-mediated neuronal differentiation in neuroblastoma.

Knelson EH, Gaviglio AL, Tewari AK, Armstrong MB, Mythreye K, Blobe GC.

J Clin Invest. 2013 Nov;123(11):4786-98.


The type III TGFβ receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells.

Oh SY, Knelson EH, Blobe GC, Mythreye K.

Biochem J. 2013 Aug 15;454(1):79-89. doi: 10.1042/BJ20121701.


Endoglin mediates fibronectin/α5β1 integrin and TGF-β pathway crosstalk in endothelial cells.

Tian H, Mythreye K, Golzio C, Katsanis N, Blobe GC.

EMBO J. 2012 Oct 3;31(19):3885-900. doi: 10.1038/emboj.2012.246. Epub 2012 Aug 31.

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