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The ancient drug salicylate directly activates AMP-activated protein kinase.
Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ, Peggie MW, Zibrova D, Green KA, Mustard KJ, Kemp BE, Sakamoto K, Steinberg GR, Hardie DG. Hawley SA, et al. Among authors: mustard kj. Science. 2012 May 18;336(6083):918-22. doi: 10.1126/science.1215327. Epub 2012 Apr 19. Science. 2012. PMID: 22517326 Free PMC article.
AMP-activated protein kinase and hypoxic pulmonary vasoconstriction.
Robertson TP, Mustard KJ, Lewis TH, Clark JH, Wyatt CN, Blanco EA, Peers C, Hardie DG, Evans AM. Robertson TP, et al. Among authors: mustard kj. Eur J Pharmacol. 2008 Oct 24;595(1-3):39-43. doi: 10.1016/j.ejphar.2008.07.035. Epub 2008 Jul 30. Eur J Pharmacol. 2008. PMID: 18703047 Free PMC article.
AMP-activated protein kinase mediates carotid body excitation by hypoxia.
Wyatt CN, Mustard KJ, Pearson SA, Dallas ML, Atkinson L, Kumar P, Peers C, Hardie DG, Evans AM. Wyatt CN, et al. Among authors: mustard kj. J Biol Chem. 2007 Mar 16;282(11):8092-8. doi: 10.1074/jbc.M608742200. Epub 2006 Dec 19. J Biol Chem. 2007. PMID: 17179156 Free PMC article.
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