Multimodality Raman and photoacoustic imaging of surface-enhanced-Raman-scattering-targeted tumor cells

Wei Shi; Robert J Paproski; Peng Shao; Alexander Forbrich; John D Lewis; Roger J Zemp

doi:10.1117/1.JBO.21.2.020503

Multimodality Raman and photoacoustic imaging of surface-enhanced-Raman-scattering-targeted tumor cells

J Biomed Opt. 2016 Feb;21(2):20503. doi: 10.1117/1.JBO.21.2.020503.

Authors

Wei Shi¹, Robert J Paproski², Peng Shao¹, Alexander Forbrich¹, John D Lewis³, Roger J Zemp¹

Affiliations

¹ University of Alberta, Department of Electrical and Computer Engineering, Second Floor ECERF, 9107-116 Street, Edmonton, Alberta, T6G 2V4, Canada.
² University of Alberta, Department of Electrical and Computer Engineering, Second Floor ECERF, 9107-116 Street, Edmonton, Alberta, T6G 2V4, CanadabUniversity of Alberta, Department of Oncology, 114 Street and 87 Avenue, Edmonton, Alberta, T6G 2E1, Canada.
³ University of Alberta, Department of Oncology, 114 Street and 87 Avenue, Edmonton, Alberta, T6G 2E1, Canada.

PMID: 26915041
DOI: 10.1117/1.JBO.21.2.020503

Abstract

A multimodality Raman and photoacoustic imaging system is presented. This system has ultralow background and can detect tumor cells labeled with modified surface-enhanced-Raman-scattering (SERS) nanoparticles in vivo. Photoacoustic imaging provides microvascular context and can potentially be used to guide magnetic trapping of circulating tumor cells for SERS detection in animal models.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Equipment Design
HeLa Cells
Humans
Magnetite Nanoparticles / chemistry*
Multimodal Imaging / methods*
Neoplastic Cells, Circulating / chemistry*
Phantoms, Imaging
Rats
Spectrum Analysis, Raman / methods*

Substances

Magnetite Nanoparticles