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IEEE Trans Biomed Eng. 2011 Dec;58(12):3469-74. doi: 10.1109/TBME.2011.2169256. Epub 2011 Sep 23.

Integrative, multimodal analysis of glioblastoma using TCGA molecular data, pathology images, and clinical outcomes.

Author information

1
Center for Comprehensive Informatics, Emory University, Atlanta, GA 30322, USA. jun.kong@emory.edu

Abstract

Multimodal, multiscale data synthesis is becoming increasingly critical for successful translational biomedical research. In this letter, we present a large-scale investigative initiative on glioblastoma, a high-grade brain tumor, with complementary data types using in silico approaches. We integrate and analyze data from The Cancer Genome Atlas Project on glioblastoma that includes novel nuclear phenotypic data derived from microscopic slides, genotypic signatures described by transcriptional class and genetic alterations, and clinical outcomes defined by response to therapy and patient survival. Our preliminary results demonstrate numerous clinically and biologically significant correlations across multiple data types, revealing the power of in silico multimodal data integration for cancer research.

PMID:
21947516
PMCID:
PMC3292263
DOI:
10.1109/TBME.2011.2169256
[Indexed for MEDLINE]
Free PMC Article

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