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Establishment of a multi-specific monoclonal antibody MsMab-1 recognizing both IDH1 and IDH2 mutations.
Kato Kaneko M, Ogasawara S, Kato Y. Kato Kaneko M, et al. Tohoku J Exp Med. 2013 Jun;230(2):103-9. doi: 10.1620/tjem.230.103. Tohoku J Exp Med. 2013. PMID: 23782684 Free article.
Western blot analysis also revealed that MsMab-1 reacted with recombinant proteins of IDH1-R132H, IDH1-R132S, and IDH1-R132G, but not with wild type IDH1 and other IDH1 mutations, indicating that MsMab-1 is a multi-specific anti-mutated IDH1 mAb. ...Mo …
Western blot analysis also revealed that MsMab-1 reacted with recombinant proteins of IDH1-R132H, IDH1-R132S, and IDH1-R132G, …
Monoclonal antibody MsMab-1 against mutated IDH1 and IDH2.
[No authors listed] [No authors listed] Monoclon Antib Immunodiagn Immunother. 2013 Dec;32(6):429. doi: 10.1089/mab.2013.0056. Monoclon Antib Immunodiagn Immunother. 2013. PMID: 24328750 No abstract available.
Structural basis for multi-specific peptide recognition by the anti-IDH1/2 monoclonal antibody, MsMab-1.
Kitago Y, Kaneko MK, Ogasawara S, Kato Y, Takagi J. Kitago Y, et al. Biochem Biophys Res Commun. 2016 Sep 23;478(3):1274-9. doi: 10.1016/j.bbrc.2016.08.110. Epub 2016 Aug 20. Biochem Biophys Res Commun. 2016. PMID: 27553275
To detect this mutation, several antibodies that can distinguish between mutant and wild-type enzymes have been established. One of which, MsMab-1, has a unique multi-specific character against several types of mutated IDH1/2. This promiscuous character is in remark …
To detect this mutation, several antibodies that can distinguish between mutant and wild-type enzymes have been established. One of which, …
Diagnostic advantage of double immunohistochemistry using two mutation-specific anti-IDH antibodies (HMab-1 and MsMab-1) in gliomas.
Takano S, Kato Y, Yamamoto T, Liu X, Ishikawa E, Kaneko MK, Ogasawara S, Matsuda M, Noguchi M, Matsumura A. Takano S, et al. Brain Tumor Pathol. 2015 Jul;32(3):169-75. doi: 10.1007/s10014-015-0214-8. Epub 2015 Feb 5. Brain Tumor Pathol. 2015. PMID: 25652153
For the first screening, we used HMab-1 IHC and for the second, (of HMab-1-negative cases) we used MsMab-1 IHC. The double IHC screening results were confirmed using sequence analysis (100% specificity and 100% sensitivity). ...IDH sequencing procedures are popular …
For the first screening, we used HMab-1 IHC and for the second, (of HMab-1-negative cases) we used MsMab-1 IHC. The double IHC …
Isocitrate dehydrogenase 2 mutation is a frequent event in osteosarcoma detected by a multi-specific monoclonal antibody MsMab-1.
Liu X, Kato Y, Kaneko MK, Sugawara M, Ogasawara S, Tsujimoto Y, Naganuma Y, Yamakawa M, Tsuchiya T, Takagi M. Liu X, et al. Cancer Med. 2013 Dec;2(6):803-14. doi: 10.1002/cam4.149. Epub 2013 Oct 17. Cancer Med. 2013. PMID: 24403254 Free PMC article.
Furthermore, MsMab-1 stained IDH2-R172S-expressing osteosarcoma tissues in immunohistochemistry. The MsMab-1 stained nine of 32 (28.1%) osteosarcomas in a tissue microarray. ...
Furthermore, MsMab-1 stained IDH2-R172S-expressing osteosarcoma tissues in immunohistochemistry. The MsMab-1 sta …
Multi-specific monoclonal antibody MsMab-2 recognizes IDH1-R132L and IDH2-R172M mutations.
Ogasawara S, Kaneko MK, Tsujimoto Y, Liu X, Kato Y. Ogasawara S, et al. Monoclon Antib Immunodiagn Immunother. 2013 Dec;32(6):377-81. doi: 10.1089/mab.2013.0050. Monoclon Antib Immunodiagn Immunother. 2013. PMID: 24328739
Arginine 132 (R132) of IDH1 and arginine 172 (R172) of IDH2 are functionally important residues. Although MsMab-1 monoclonal antibody (MAb), which is multi-specific for mutated IDH1/2, has been established, MsMab-1 does not react with all IDH1/2 mutati …
Arginine 132 (R132) of IDH1 and arginine 172 (R172) of IDH2 are functionally important residues. Although MsMab-1 monoclonal a …
Specific monoclonal antibodies against IDH1/2 mutations as diagnostic tools for gliomas.
Kato Y. Kato Y. Brain Tumor Pathol. 2015 Jan;32(1):3-11. doi: 10.1007/s10014-014-0202-4. Epub 2014 Oct 17. Brain Tumor Pathol. 2015. PMID: 25324168 Review.
To date, several monoclonal antibodies (mAbs) specific for IDH1/2 mutations such as anti-IDH1-R132H mAbs (clone H09, clone IMab-1, and clone HMab-1) or an anti-IDH1-R132S mAb (clone SMab-1) have been established. Furthermore, one of multi-specific mAbs, MsMab-1, rec …
To date, several monoclonal antibodies (mAbs) specific for IDH1/2 mutations such as anti-IDH1-R132H mAbs (clone H09, clone IMab-1, and clone …
Establishment of Anti-Human ATRX Monoclonal Antibody AMab-6.
Ogasawara S, Fujii Y, Kaneko MK, Oki H, Sabit H, Nakada M, Suzuki H, Ichimura K, Komori T, Kato Y. Ogasawara S, et al. Monoclon Antib Immunodiagn Immunother. 2016 Oct;35(5):254-258. doi: 10.1089/mab.2016.0037. Monoclon Antib Immunodiagn Immunother. 2016. PMID: 27788029 Free PMC article.
We have developed many mAbs against IDH mutants, including HMab-1/HMab-2 against IDH1-R132H and multispecific mAbs MsMab-1/MsMab-2 against IDH1/2 mutations. In contrast, highly sensitive mAbs against ATRX remain to be established. ...
We have developed many mAbs against IDH mutants, including HMab-1/HMab-2 against IDH1-R132H and multispecific mAbs MsMab-1/MsM …
IDH1/2 Mutations in Sinonasal Undifferentiated Carcinomas : Previously Undescribed IDH2 R172K and R140x Variants.
Kakkar A, Rathor A, Ashraf SF, Singh V, Sikka K, Jain D. Kakkar A, et al. Am J Surg Pathol. 2022 Sep 1;46(9):1284-1290. doi: 10.1097/PAS.0000000000001912. Epub 2022 May 2. Am J Surg Pathol. 2022. PMID: 35486703
Immunohistochemistry was performed using IDH1/2 mutant-specific antibody MsMab-1. Quantitative real-time polymerase chain reaction (qPCR) was performed on genomic DNA extracted from formalin-fixed paraffin-embedded tissue using 2 kits to detect IDH1/2 mutations. ...
Immunohistochemistry was performed using IDH1/2 mutant-specific antibody MsMab-1. Quantitative real-time polymerase chain reac …
A novel monoclonal antibody SMab-2 recognizes endogenous IDH2-R172S of chondrosarcoma.
Liu X, Ogasawara S, Kaneko MK, Oki H, Hozumi Y, Goto K, Takagi M, Kato Y. Liu X, et al. Biochem Biophys Res Commun. 2015 Apr 17;459(4):636-42. doi: 10.1016/j.bbrc.2015.02.162. Epub 2015 Mar 6. Biochem Biophys Res Commun. 2015. PMID: 25753205
To date, several monoclonal antibodies (mAbs) specific for IDH2 mutations have been established, such as KMab-1 against IDH2-R172K, MMab-1 against IDH2-R172M, and WMab-1 against IDH2-R172W. Although a multi-specific mAb MsMab-1 reacted with IDH2-R172G and IDH2-R172S …
To date, several monoclonal antibodies (mAbs) specific for IDH2 mutations have been established, such as KMab-1 against IDH2-R172K, MMab-1 a …
12 results