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Rev Esp Cir Ortop Traumatol. 2014 Jul-Aug;58(4):201-5. doi: 10.1016/j.recot.2014.01.002. Epub 2014 May 10.

[Molecular repair mechanisms using the Intratissue Percutaneous Electrolysis technique in patellar tendonitis].

[Article in Spanish]

Author information

1
Departamento de Traumatología y Rehabilitación Deportiva, CEREDE Sports Medicine, Barcelona, España. Electronic address: drabat@cerede.es.
2
Departamento de Fisiología, Facultad de Medicina de Valencia, Valencia, España.
3
Servicio de Cirugía Ortopédica y Traumatología, Hospital de la Santa Creu i Sant Pau, Universidad Autónoma de Barcelona, Barcelona, España; Institut Català de Traumatologia i Medicina de l'Esport (ICATME)-Instituto Universitario Dexeus, Universidad Autónoma de Barcelona, Barcelona, España.
4
Departamento de Traumatología y Rehabilitación Deportiva, CEREDE Sports Medicine, Barcelona, España.
5
Departamento de Medicina Física y Rehabilitación, New Jersey Medical School, Newark, New Jersey, Estados Unidos de América.

Abstract

OBJECTIVE:

To investigate the molecular mechanisms of tissue response after treatment with the Intratissue Percutaneous Electrolysis (EPI(®)) technique in collagenase-induced tendinopathy in Sprague-Dawley rats.

METHODS:

Tendinopathy was induced by injecting 50 μg of type i collagenase into the patellar tendon of 24 Sprague Dawley rats of 7 months of age and weighting 300 g. The sample was divided into 4 groups: the control group, collagenase group, and two EPI(®) technique treatment groups of 3 and 6 mA, respectively. An EPI(®) treatment session was applied, and after 3 days, the tendons were analysed using immunoblotting and electrophoresis techniques. An analysis was also made of cytochrome C protein, Smac/Diablo, vascular endothelial growth factor and its receptor 2, as well as the nuclear transcription factor peroxisome proliferator-activated receptor gamma.

RESULTS:

A statistically significant increase, compared to the control group, was observed in the expression of cytochrome C, Smac/Diablo, vascular endothelial growth factor, its receptor 2 and peroxisome proliferator-activated receptor gamma in the groups in which the EPI(®) technique was applied.

CONCLUSIONS:

EPI(®) technique produces an increase in anti-inflammatory and angiogenic molecular mechanisms in collagenase-induced tendon injury in rats.

KEYWORDS:

Electrólisis Percutánea Intratisular; Intratissue Percutaneous Electrolysis; Mecanismos moleculares; Molecular mechanisms; Regeneración; Regeneration; Tendinopathy; Tendinopatía; Tendon; Tendón

PMID:
24821478
DOI:
10.1016/j.recot.2014.01.002
[Indexed for MEDLINE]

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