Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

Fatemeh Forouzanfar; George Barreto; Muhammed Majeed; Amirhossein Sahebkar

doi:10.1002/biof.1522

Modulatory effects of curcumin on heat shock proteins in cancer: A promising therapeutic approach

Biofactors. 2019 Sep;45(5):631-640. doi: 10.1002/biof.1522. Epub 2019 May 28.

Authors

Fatemeh Forouzanfar^{1

2}, George Barreto^{3

4}, Muhammed Majeed⁵, Amirhossein Sahebkar^{6

7

8}

Affiliations

¹ Neuroscience Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
² Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Departamento de Nutrición yBioquímica, Facultad de Ciencias, Pontificia Universidad Javeriana, Bogotá, D.C., Colombia.
⁴ Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile.
⁵ Sabinsa Corporation, East Windsor, New Jersey.
⁶ Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
⁷ Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
⁸ Department of Medical Biotechnology,School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

PMID: 31136038
DOI: 10.1002/biof.1522

Abstract

Cancer metastasis represents a multistep process, including alteration of cell adhesion/motility in the microenvironment and sustained angiogenesis, which is essential for supporting cancer growth in tissues that are distant from the primary tumor. There is growing evidence suggesting that heat shock proteins (HSPs) (also known as heat stress proteins), which constitute a family of stress-inducible proteins, may be involved in the pathogenesis of cancer. Curcumin (diferuloylmethane) is a potent anti-inflammatory, antioxidant, antimicrobial, and antitumor agent. Curcumin has been shown to regulate different members of HSPs including HSP27, HSP40, HSP60, HSP70, and HSP90 in cancer. Here, we present extent findings suggesting that curcumin may act as a potential therapeutic agent for the treatment of cancer through its regulation of HSPs.

Keywords: cancer; curcumin; heat shock protein; herbal medicine.

Publication types

Review

MeSH terms

Antineoplastic Agents, Phytogenic / pharmacology*
Chaperonin 60 / antagonists & inhibitors
Chaperonin 60 / genetics
Chaperonin 60 / metabolism
Curcumin / pharmacology*
Gene Expression Regulation, Neoplastic / drug effects*
HSP40 Heat-Shock Proteins / agonists
HSP40 Heat-Shock Proteins / genetics
HSP40 Heat-Shock Proteins / metabolism
HSP70 Heat-Shock Proteins / agonists
HSP70 Heat-Shock Proteins / genetics
HSP70 Heat-Shock Proteins / metabolism
HSP90 Heat-Shock Proteins / antagonists & inhibitors
HSP90 Heat-Shock Proteins / genetics
HSP90 Heat-Shock Proteins / metabolism
Heat-Shock Proteins / antagonists & inhibitors
Heat-Shock Proteins / genetics
Heat-Shock Proteins / metabolism
Humans
Lymphatic Metastasis
Mitochondrial Proteins / antagonists & inhibitors
Mitochondrial Proteins / genetics
Mitochondrial Proteins / metabolism
Molecular Chaperones / antagonists & inhibitors
Molecular Chaperones / genetics
Molecular Chaperones / metabolism
Neoplasm Proteins / agonists
Neoplasm Proteins / antagonists & inhibitors
Neoplasm Proteins / genetics*
Neoplasm Proteins / metabolism
Neoplasms / drug therapy*
Neoplasms / genetics
Neoplasms / metabolism
Neoplasms / pathology
Neovascularization, Pathologic / genetics
Neovascularization, Pathologic / metabolism
Neovascularization, Pathologic / pathology
Neovascularization, Pathologic / prevention & control*
Signal Transduction
Tumor Microenvironment / drug effects
Tumor Microenvironment / genetics

Substances

Antineoplastic Agents, Phytogenic
Chaperonin 60
DNAJB1 protein, human
HSP40 Heat-Shock Proteins
HSP70 Heat-Shock Proteins
HSP90 Heat-Shock Proteins
HSPB1 protein, human
HSPD1 protein, human
Heat-Shock Proteins
Mitochondrial Proteins
Molecular Chaperones
Neoplasm Proteins
Curcumin