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Cell Metab. 2016 Jun 14;23(6):963-964. doi: 10.1016/j.cmet.2016.05.015.

Modulating Cholesterol Homeostasis to Build a Better T Cell.

Author information

1
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
2
Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: sbensinger@mednet.ucla.edu.

Abstract

There is great interest in discovering targets for in vitro manipulation of autologous T cells that enhance their cytotoxicity against tumor targets as a potent cancer immunotherapy. In a recent Nature paper, Xu and colleagues reveal new insights into the link between cellular cholesterol metabolism and CD8 T cell functions.

PMID:
27304495
DOI:
10.1016/j.cmet.2016.05.015
[Indexed for MEDLINE]
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