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Mitochondria as biosynthetic factories for cancer proliferation.
Ahn CS, Metallo CM. Ahn CS, et al. Cancer Metab. 2015 Jan 25;3(1):1. doi: 10.1186/s40170-015-0128-2. eCollection 2015. Cancer Metab. 2015. PMID: 25621173 Free PMC article.
Unchecked growth and proliferation is a hallmark of cancer, and numerous oncogenic mutations reprogram cellular metabolism to fuel these processes. ...Here, we review the biosynthetic roles of mitochondrial metabolism in tumors and highlight spe …
Unchecked growth and proliferation is a hallmark of cancer, and numerous oncogenic mutations reprogram cellular metabolism …
STOML2 restricts mitophagy and increases chemosensitivity in pancreatic cancer through stabilizing PARL-induced PINK1 degradation.
Qin C, Wang Y, Zhao B, Li Z, Li T, Yang X, Zhao Y, Wang W. Qin C, et al. Cell Death Dis. 2023 Mar 11;14(3):191. doi: 10.1038/s41419-023-05711-5. Cell Death Dis. 2023. PMID: 36906621 Free PMC article.
Mitochondria, as the power factory in cancer cells, are involved in the process of chemoresistance. ...In this study, using a tissue microarray (TMA), we found that high STOML2 expression was correlated with higher survival of patients with pancreatic canc …
Mitochondria, as the power factory in cancer cells, are involved in the process of chemoresistance. ...In this study, u …
Mitochondria: Endosymbiont bacteria DNA sequence as a target against cancer.
Nagase H, Watanabe T, Koshikawa N, Yamamoto S, Takenaga K, Lin J. Nagase H, et al. Cancer Sci. 2021 Dec;112(12):4834-4843. doi: 10.1111/cas.15143. Epub 2021 Oct 4. Cancer Sci. 2021. PMID: 34533888 Free PMC article. Review.
As the energy factory for the cell, the mitochondrion, through its role of adenosine triphosphate production by oxidative phosphorylation, can be regarded as the guardian of well regulated cellular metabolism; the integrity of mitochondrial functions, however, is pa …
As the energy factory for the cell, the mitochondrion, through its role of adenosine triphosphate production by oxidative phosphoryla …
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R… See abstract for full author list ➔ Klionsky DJ, et al. Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8. Autophagy. 2021. PMID: 33634751 Free PMC article.
Mitochondria-anchoring self-assembled nanoparticles for multi-path energy depletion: A "nano bomb" in chemo-co-starvation therapy.
Zhang K, Zhu J, Wang R, Zhu W, Zhang Z, Gong L, Feng F, Liu W, Han L, Qu W. Zhang K, et al. Int J Pharm. 2023 Jul 25;642:123180. doi: 10.1016/j.ijpharm.2023.123180. Epub 2023 Jun 25. Int J Pharm. 2023. PMID: 37364784
The feasible cancer starvation therapy could inhibit tumor progression by blocking energy supplements, however, the mono-therapeutic modality showed limited curing efficacy due to heterogeneity and abnormal energy metabolism of TNBC. ...Our research indicated that N …
The feasible cancer starvation therapy could inhibit tumor progression by blocking energy supplements, however, the mono-therapeutic …
The Influence of Mitochondrial Energy and 1C Metabolism on the Efficacy of Anticancer Drugs: Exploring Potential Mechanisms of Resistance.
Franczak M, Toenshoff I, Jansen G, Smolenski RT, Giovannetti E, Peters GJ. Franczak M, et al. Curr Med Chem. 2023;30(11):1209-1231. doi: 10.2174/0929867329666220401110418. Curr Med Chem. 2023. PMID: 35366764 Review.
Mitochondria are the main energy factory in living cells. To rapidly proliferate and metastasize, neoplastic cells increase their energy requirements. ...Another mechanism is the high expression of one-carbon (1C) metabolism enzymes. Again, this allows …
Mitochondria are the main energy factory in living cells. To rapidly proliferate and metastasize, neoplastic cells incr …
Antitumor Effect of Hyperoside Loaded in Charge Reversed and Mitochondria-Targeted Liposomes.
Feng Y, Qin G, Chang S, Jing Z, Zhang Y, Wang Y. Feng Y, et al. Int J Nanomedicine. 2021 Apr 28;16:3073-3089. doi: 10.2147/IJN.S297716. eCollection 2021. Int J Nanomedicine. 2021. PMID: 33953556 Free PMC article.
INTRODUCTION: Hyperoside (HYP), a flavonol glycoside compound, has been shown to significantly inhibit the proliferation of malignant tumors. Mitochondria serve as both "energy factories" and "suicide weapon stores" of cells. ...OBJECTIVE: We report a novel d …
INTRODUCTION: Hyperoside (HYP), a flavonol glycoside compound, has been shown to significantly inhibit the proliferation of malignant …