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Behav Brain Res. 2018 Jan 15;336:211-218. doi: 10.1016/j.bbr.2017.09.010. Epub 2017 Sep 5.

Mindfulness and dynamic functional neural connectivity in children and adolescents.

Author information

1
Department of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, MI, 48201, United States. Electronic address: hmarusak@med.wayne.edu.
2
Department of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, MI, 48201, United States.
3
Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States; Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, United States.
4
Department of Psychology and Center for Applied Neuroscience, University of Cyprus, Nicosia, 1678, Cyprus; Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK.
5
Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, 87131, United States; The Mind Research Network, Albuquerque, NM, 87131, United States.
6
Kids Kicking Cancer, Southfield, MI, 48034, United States; Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, 48201, United States.
7
Kids Kicking Cancer, Southfield, MI, 48034, United States.
8
Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, 48201, United States; Children's Hospital of Michigan, Detroit, MI, 48201, United States.
9
Department of Pharmacy Practice, Wayne State University College of Pharmacy and Health Sciences, Detroit, MI, 48201, United States; Department of Pharmaceutical Sciences, Wayne State University College of Pharmacy and Health Sciences, Detroit, MI, 48201, United States; Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, 48201, United States.

Abstract

BACKGROUND:

Interventions that promote mindfulness consistently show salutary effects on cognition and emotional wellbeing in adults, and more recently, in children and adolescents. However, we lack understanding of the neurobiological mechanisms underlying mindfulness in youth that should allow for more judicious application of these interventions in clinical and educational settings.

METHODS:

Using multi-echo multi-band fMRI, we examined dynamic (i.e., time-varying) and conventional static resting-state connectivity between core neurocognitive networks (i.e., salience/emotion, default mode, central executive) in 42 children and adolescents (ages 6-17).

RESULTS:

We found that trait mindfulness in youth relates to dynamic but not static resting-state connectivity. Specifically, more mindful youth transitioned more between brain states over the course of the scan, spent overall less time in a certain connectivity state, and showed a state-specific reduction in connectivity between salience/emotion and central executive networks. The number of state transitions mediated the link between higher mindfulness and lower anxiety, providing new insights into potential neural mechanisms underlying benefits of mindfulness on psychological health in youth.

CONCLUSIONS:

Our results provide new evidence that mindfulness in youth relates to functional neural dynamics and interactions between neurocognitive networks, over time.

KEYWORDS:

Default mode network; Independent components analysis; Intrinsic connectivity; Meditation; Resting-state; Salience network

PMID:
28887198
PMCID:
PMC5610942
[Available on 2019-01-15]
DOI:
10.1016/j.bbr.2017.09.010
[Indexed for MEDLINE]

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