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Acta Pharmacol Sin. 2014 Apr;35(4):433-43. doi: 10.1038/aps.2013.188. Epub 2014 Mar 10.

Microvesicles and diabetic complications--novel mediators, potential biomarkers and therapeutic targets.

Author information

1
Key Laboratory of Hormones and Development (Ministry of Health) Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China.
2
Section of Endocrinology, Diabetes and Metabolic Diseases, Department of Medicine, Temple University School of Medicine, Philadelphia, PA 19140, USA.

Abstract

Microvesicles (MVs), also known as microparticles, are small membrane vesicles released from different cell types under different conditions. MVs have been detected in the circulation and in organs/tissues in various diseases, including diabetes. Patients with different types of diabetes and complications have different cellular MV patterns. Studies have shown that MVs may mediate vascular thrombosis, vascular inflammation, angiogenesis, and other pathological processes of the disease through their procoagulant, pro-inflammatory, pro-angiogenic, proteolytic, and other properties. Therefore, MVs contribute to the development of diabetic macrovascular and microvascular complications. In addition, clinical studies have indicated that changes in MV number and composition may reflect the pathophysiological conditions of disease, and therefore, may serve as potential biomarkers for diagnostic and prognostic use. Understanding MVs' involvement in the pathophysiological conditions may provide insight into disease mechanisms and would also be helpful for the development of novel therapeutic strategies in the future. Here, we review the latest publications from our group and other groups and focus on the involvement of MVs in diabetic complications.

PMID:
24608676
PMCID:
PMC4813723
DOI:
10.1038/aps.2013.188
[Indexed for MEDLINE]
Free PMC Article

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