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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1925 2
1929 1
1932 1
1933 3
1934 1
1936 1
1937 1
1938 2
1939 2
1940 1
1941 3
1942 4
1944 1
1945 6
1946 14
1947 19
1948 21
1949 13
1950 24
1951 34
1952 32
1953 36
1954 31
1955 52
1956 68
1957 66
1958 64
1959 67
1960 84
1961 108
1962 135
1963 148
1964 171
1965 220
1966 243
1967 283
1968 279
1969 383
1970 426
1971 482
1972 562
1973 571
1974 660
1975 1530
1976 1721
1977 1713
1978 1781
1979 1879
1980 2116
1981 2451
1982 2786
1983 3143
1984 3633
1985 3735
1986 3945
1987 4064
1988 3971
1989 4241
1990 4691
1991 4586
1992 4345
1993 4506
1994 4293
1995 4553
1996 4696
1997 4686
1998 4709
1999 4839
2000 4991
2001 5137
2002 5380
2003 5603
2004 5876
2005 6513
2006 7061
2007 7565
2008 7800
2009 7996
2010 8966
2011 9887
2012 10936
2013 11709
2014 12508
2015 13211
2016 14351
2017 15019
2018 16179
2019 18217
2020 21305
2021 24153
2022 26897
2023 26322
2024 9353

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360,900 results

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Page 1
Pharmacokinetics.
Fan J, de Lannoy IA. Fan J, et al. Biochem Pharmacol. 2014 Jan 1;87(1):93-120. doi: 10.1016/j.bcp.2013.09.007. Epub 2013 Sep 17. Biochem Pharmacol. 2014. PMID: 24055064 Review.
Following a brief introduction as to why knowledge of the PK properties of an NCE is critical to its selection as a lead candidate in a drug discovery program and/or its use as a functional research tool, the present article presents an overview of PK principles, including practi …
Following a brief introduction as to why knowledge of the PK properties of an NCE is critical to its selection as a lead candidate in a drug …
Are circulating metabolites important in pharmacokinetic drug-drug interactions? A retroanalysis of clinical data.
Zhao YS, Chen F, Li L. Zhao YS, et al. Curr Drug Metab. 2014;15(8):767-90. doi: 10.2174/1389200216666150223152113. Curr Drug Metab. 2014. PMID: 25705906 Review.
Comprehensive, systematic and mechanistic approaches have been applied in the evaluation, propagation and management of the interaction potential of a new drug during its development and clinical use. However, the role of drug metabolite(s) in DDIs was not extensive …
Comprehensive, systematic and mechanistic approaches have been applied in the evaluation, propagation and management of the interaction pote …
Metabolites and bioequivalence: past and present.
Jackson AJ, Robbie G, Marroum P. Jackson AJ, et al. Clin Pharmacokinet. 2004;43(10):655-72. doi: 10.2165/00003088-200443100-00002. Clin Pharmacokinet. 2004. PMID: 15244496 Review.
Although it is widely recognised that measurement of metabolite concentrations is crucial to understanding the clinical pharmacology characteristics of a new molecular entity, a clear consensus on the role of metabolites in the assessment of bioequivalence has never …
Although it is widely recognised that measurement of metabolite concentrations is crucial to understanding the clinical pharmacology …
Pharmacologically active drug metabolites: impact on drug discovery and pharmacotherapy.
Obach RS. Obach RS. Pharmacol Rev. 2013 Feb 13;65(2):578-640. doi: 10.1124/pr.111.005439. Print 2013 Apr. Pharmacol Rev. 2013. PMID: 23406671 Review.
Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite. ...Finally, over 10 …
Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations …
Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry.
Ma S, Subramanian R. Ma S, et al. J Mass Spectrom. 2006 Sep;41(9):1121-39. doi: 10.1002/jms.1098. J Mass Spectrom. 2006. PMID: 16967439 Review.
Metabolic activation of a drug leading to reactive metabolite(s) that can covalently modify proteins is considered an initial step that may lead to drug-induced organ toxicities. ...Techniques for high-throughput screening and quantitation of reactive metabolite …
Metabolic activation of a drug leading to reactive metabolite(s) that can covalently modify proteins is considered an initial …
New insight into gut microbiota-derived metabolites to enhance liver regeneration via network pharmacology study.
Oh KK, Choi I, Gupta H, Raja G, Sharma SP, Won SM, Jeong JJ, Lee SB, Cha MG, Kwon GH, Jeong MK, Min BH, Hyun JY, Eom JA, Park HJ, Yoon SJ, Choi MR, Kim DJ, Suk KT. Oh KK, et al. Artif Cells Nanomed Biotechnol. 2023 Dec;51(1):1-12. doi: 10.1080/21691401.2022.2155661. Artif Cells Nanomed Biotechnol. 2023. PMID: 36562095
We intended to identify favourable metabolite(s) and pharmacological mechanism(s) of gut microbiota (GM) for liver regeneration (LR) through network pharmacology. ...Furthermore, we performed a molecular docking assay on the active metabolite(s) and ta …
We intended to identify favourable metabolite(s) and pharmacological mechanism(s) of gut microbiota (GM) for liver regeneratio …
The role of metabolites in bioequivalence.
Midha KK, Rawson MJ, Hubbard JW. Midha KK, et al. Pharm Res. 2004 Aug;21(8):1331-44. doi: 10.1023/b:pham.0000036906.65263.da. Pharm Res. 2004. PMID: 15359567 Review.
The role of metabolites in bioequivalence studies has been a contentious issue for many years. ...We therefore applied those principles (based on estimates of intrinsic clearance after oral administration of the parent drug) to four bioequivalence studies from our archives …
The role of metabolites in bioequivalence studies has been a contentious issue for many years. ...We therefore applied those principl …
Identification of novel cardiovascular disease associated metabolites using untargeted metabolomics.
Tabrez S, Shait Mohammed MR, Jabir NR, Khan MI. Tabrez S, et al. Biol Chem. 2021 Jan 20;402(6):749-757. doi: 10.1515/hsz-2020-0331. Print 2021 May 26. Biol Chem. 2021. PMID: 33951765
In the current study, we used an untargeted metabolomic approach to identify possible metabolite(s) that associate well with the CVD and could serve either as therapeutic target or disease-associated metabolite. ...Out of these metabolites, we identifi …
In the current study, we used an untargeted metabolomic approach to identify possible metabolite(s) that associate well with t …
Perspectives on non-clinical safety evaluation of drug metabolites through the JSOT workshop.
Minagawa T, Nakano K, Furuta S, Iwasa T, Takekawa K, Minato K, Koga T, Sato T, Kawashima K, Kurahashi Y, Onodera H, Naito S, Nakamura K. Minagawa T, et al. J Toxicol Sci. 2012;37(4):667-73. doi: 10.2131/jts.37.667. J Toxicol Sci. 2012. PMID: 22863847 Free article. Review.
The prompt and appropriate safety assessment of drug metabolite(s) was mentioned in regulatory guidances such as an International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) guidance, entitled "Guidan …
The prompt and appropriate safety assessment of drug metabolite(s) was mentioned in regulatory guidances such as an Internatio …
Increased Excretion of Mast Cell Mediator Metabolites During Mast Cell Activation Syndrome.
Butterfield JH. Butterfield JH. J Allergy Clin Immunol Pract. 2023 Aug;11(8):2542-2546. doi: 10.1016/j.jaip.2023.02.017. Epub 2023 Feb 28. J Allergy Clin Immunol Pract. 2023. PMID: 36863614
OBJECTIVE: Ratios of acute/baseline levels for each urinary metabolite that accompanied tryptase increases of 20% plus 2 ng/mL were determined. ...Patients with the requisite increase in serum tryptase during MCAS were examined for those who also had acute/baseline measure …
OBJECTIVE: Ratios of acute/baseline levels for each urinary metabolite that accompanied tryptase increases of 20% plus 2 ng/mL were d …
360,900 results
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