Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer's disease via SIRT1/NF-κB pathway

Metab Brain Dis. 2016 Aug;31(4):771-8. doi: 10.1007/s11011-016-9813-2. Epub 2016 Feb 24.

Abstract

Age-related inflammation is the predominant factor for neurodegenerative diseases like Alzheimer's disease (AD). In the present study, we examined memory performance and neuroinflammation in D-galactose (D-gal)-induced sub-acute aging model of rats. Our results demonstrated that chronic administration of D-gal (120 mg/kg) produced cognitive impairment as determined by Morris water maze (MWM) test and step-down passive avoidance test. D-gal also activated nuclear factor kappa B (NF-κB) p65/RelA by down-regulating the expression level of sirtuins 1 (SIRT1) in the hippocampus. Treatment with Salidroside (Sal, 20, 40 mg/kg) for 28 days ameliorated D-gal-induced memory deficits and inflammatory mediators including tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). Moreover, D-gal-induced activation of NF-κB signaling pathway in the brain was also inhibited by Sal via up-regulating SIRT1. These results suggest that D-gal-triggered memory impairment and inflammatory response may be associated with SIRT1/NF-κB signaling pathway, whereas treatment with Sal could positively affect these changes in hippocampus.

Keywords: Aging; Cognitive impairment; Neuroinflammation; SIRT1/NF-κB pathway; Sal.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / chemically induced
  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / pathology
  • Animals
  • Avoidance Learning / drug effects
  • Brain / drug effects*
  • Brain / metabolism
  • Brain / pathology
  • Cognition / drug effects
  • Disease Models, Animal
  • Galactose
  • Glucosides / pharmacology
  • Glucosides / therapeutic use*
  • Inflammation / drug therapy*
  • Inflammation / metabolism
  • Inflammation / pathology
  • Male
  • Memory / drug effects
  • NF-kappa B / metabolism*
  • Phenols / pharmacology
  • Phenols / therapeutic use*
  • Rats
  • Rats, Sprague-Dawley
  • Signal Transduction / drug effects*
  • Sirtuin 1 / metabolism*

Substances

  • Glucosides
  • NF-kappa B
  • Phenols
  • Sirtuin 1
  • rhodioloside
  • Galactose