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Items: 19


Genomic analysis of 220 CTCLs identifies a novel recurrent gain-of-function alteration in RLTPR (p.Q575E).

Park J, Yang J, Wenzel AT, Ramachandran A, Lee WJ, Daniels JC, Kim J, Martinez-Escala E, Amankulor N, Pro B, Guitart J, Mendillo ML, Savas JN, Boggon TJ, Choi J.

Blood. 2017 Sep 21;130(12):1430-1440. doi: 10.1182/blood-2017-02-768234. Epub 2017 Jul 10.


Luminidependens (LD) is an Arabidopsis protein with prion behavior.

Chakrabortee S, Kayatekin C, Newby GA, Mendillo ML, Lancaster A, Lindquist S.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):6065-70. doi: 10.1073/pnas.1604478113. Epub 2016 Apr 25.


Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome.

Tsvetkov P, Mendillo ML, Zhao J, Carette JE, Merrill PH, Cikes D, Varadarajan M, van Diemen FR, Penninger JM, Goldberg AL, Brummelkamp TR, Santagata S, Lindquist S.

Elife. 2015 Sep 1;4. doi: 10.7554/eLife.08467.


HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models.

Whitesell L, Santagata S, Mendillo ML, Lin NU, Proia DA, Lindquist S.

Proc Natl Acad Sci U S A. 2014 Dec 23;111(51):18297-302. doi: 10.1073/pnas.1421323111. Epub 2014 Dec 8.


The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy.

Scherz-Shouval R, Santagata S, Mendillo ML, Sholl LM, Ben-Aharon I, Beck AH, Dias-Santagata D, Koeva M, Stemmer SM, Whitesell L, Lindquist S.

Cell. 2014 Jul 31;158(3):564-78. doi: 10.1016/j.cell.2014.05.045.


The master regulator of the cellular stress response (HSF1) is critical for orthopoxvirus infection.

Filone CM, Caballero IS, Dower K, Mendillo ML, Cowley GS, Santagata S, Rozelle DK, Yen J, Rubins KH, Hacohen N, Root DE, Hensley LE, Connor J.

PLoS Pathog. 2014 Feb 6;10(2):e1003904. doi: 10.1371/journal.ppat.1003904. eCollection 2014 Feb.


Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway.

Smith CE, Mendillo ML, Bowen N, Hombauer H, Campbell CS, Desai A, Putnam CD, Kolodner RD.

PLoS Genet. 2013 Oct;9(10):e1003869. doi: 10.1371/journal.pgen.1003869. Epub 2013 Oct 31.


DNA conformations in mismatch repair probed in solution by X-ray scattering from gold nanocrystals.

Hura GL, Tsai CL, Claridge SA, Mendillo ML, Smith JM, Williams GJ, Mastroianni AJ, Alivisatos AP, Putnam CD, Kolodner RD, Tainer JA.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17308-13. doi: 10.1073/pnas.1308595110. Epub 2013 Oct 7.


A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells.

Petrocca F, Altschuler G, Tan SM, Mendillo ML, Yan H, Jerry DJ, Kung AL, Hide W, Ince TA, Lieberman J.

Cancer Cell. 2013 Aug 12;24(2):182-96. doi: 10.1016/j.ccr.2013.07.008.


Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.

Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA Jr, Whitesell L, Lindquist S.

Science. 2013 Jul 19;341(6143):1238303. doi: 10.1126/science.1238303.


HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.

Mendillo ML, Santagata S, Koeva M, Bell GW, Hu R, Tamimi RM, Fraenkel E, Ince TA, Whitesell L, Lindquist S.

Cell. 2012 Aug 3;150(3):549-62. doi: 10.1016/j.cell.2012.06.031.


High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer.

Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, Hankinson SE, Schnitt SJ, Whitesell L, Tamimi RM, Lindquist S, Ince TA.

Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18378-83. doi: 10.1073/pnas.1115031108. Epub 2011 Oct 31.


Probing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry.

Mendillo ML, Putnam CD, Mo AO, Jamison JW, Li S, Woods VL Jr, Kolodner RD.

J Biol Chem. 2010 Apr 23;285(17):13170-82. doi: 10.1074/jbc.M110.108894. Epub 2010 Feb 24.


A conserved MutS homolog connector domain interface interacts with MutL homologs.

Mendillo ML, Hargreaves VV, Jamison JW, Mo AO, Li S, Putnam CD, Woods VL Jr, Kolodner RD.

Proc Natl Acad Sci U S A. 2009 Dec 29;106(52):22223-8. doi: 10.1073/pnas.0912250106. Epub 2009 Dec 22.


Coupling distant sites in DNA during DNA mismatch repair.

Kolodner RD, Mendillo ML, Putnam CD.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):12953-4. Epub 2007 Jul 30. No abstract available.


Biochemical basis for dominant mutations in the Saccharomyces cerevisiae MSH6 gene.

Hess MT, Mendillo ML, Mazur DJ, Kolodner RD.

Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):558-63. Epub 2006 Jan 5.


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