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Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy.

Perkovic V, Jardine MJ, Neal B, Bompoint S, Heerspink HJL, Charytan DM, Edwards R, Agarwal R, Bakris G, Bull S, Cannon CP, Capuano G, Chu PL, de Zeeuw D, Greene T, Levin A, Pollock C, Wheeler DC, Yavin Y, Zhang H, Zinman B, Meininger G, Brenner BM, Mahaffey KW; CREDENCE Trial Investigators.

N Engl J Med. 2019 Apr 14. doi: 10.1056/NEJMoa1811744. [Epub ahead of print]


Antibacterial Envelope to Prevent Cardiac Implantable Device Infection.

Tarakji KG, Mittal S, Kennergren C, Corey R, Poole JE, Schloss E, Gallastegui J, Pickett RA, Evonich R, Philippon F, McComb JM, Roark SF, Sorrentino D, Sholevar D, Cronin E, Berman B, Riggio D, Biffi M, Khan H, Silver MT, Collier J, Eldadah Z, Wright DJ, Lande JD, Lexcen DR, Cheng A, Wilkoff BL; WRAP-IT Investigators; the WRAP-IT Investigators.

N Engl J Med. 2019 May 16;380(20):1895-1905. doi: 10.1056/NEJMoa1901111. Epub 2019 Mar 17.


A Calcium Mediated Mechanism Coordinating Vascular Smooth Muscle Cell Adhesion During KCl Activation.

Huang H, Sun Z, Hill MA, Meininger GA.

Front Physiol. 2018 Dec 18;9:1810. doi: 10.3389/fphys.2018.01810. eCollection 2018.


Factors influencing longitudinal changes of circulating liver enzyme concentrations in subjects randomized to placebo in four clinical trials.

Nunez DJ, Alexander M, Yerges-Armstrong L, Singh G, Byttebier G, Fabbrini E, Waterworth D, Meininger G, Galwey N, Wallentin L, White HD, Vannieuwenhuyse B, Alazawi W, Kendrick S, Sattar N, Ferrannini E.

Am J Physiol Gastrointest Liver Physiol. 2019 Mar 1;316(3):G372-G386. doi: 10.1152/ajpgi.00051.2018. Epub 2018 Nov 29.


Temporal and molecular dynamics of human metastatic breast carcinoma cell adhesive interactions with human bone marrow endothelium analyzed by single-cell force spectroscopy.

Xie L, Sun Z, Hong Z, Brown NJ, Glinskii OV, Rittenhouse-Olson K, Meininger GA, Glinsky VV.

PLoS One. 2018 Sep 20;13(9):e0204418. doi: 10.1371/journal.pone.0204418. eCollection 2018.


Applications of Atomic Force Microscopy for Adhesion Force Measurements in Mechanotransduction.

Trache A, Xie L, Huang H, Glinsky VV, Meininger GA.

Methods Mol Biol. 2018;1814:515-528. doi: 10.1007/978-1-4939-8591-3_30.


Spontaneous oscillation in cell adhesion and stiffness measured using atomic force microscopy.

Sanyour H, Childs J, Meininger GA, Hong Z.

Sci Rep. 2018 Feb 13;8(1):2899. doi: 10.1038/s41598-018-21253-9.


Angiotensin II Type 1 Receptor Mechanoactivation Involves RGS5 (Regulator of G Protein Signaling 5) in Skeletal Muscle Arteries: Impaired Trafficking of RGS5 in Hypertension.

Hong K, Li M, Nourian Z, Meininger GA, Hill MA.

Hypertension. 2017 Dec;70(6):1264-1272. doi: 10.1161/HYPERTENSIONAHA.117.09757. Epub 2017 Oct 23.


Achieving the composite endpoint of HbA1c, body weight, and systolic blood pressure reduction with canagliflozin in patients with type 2 diabetes.

Merton K, Davies MJ, Vijapurkar U, Inman D, Meininger G.

Curr Med Res Opin. 2018 Feb;34(2):313-318. doi: 10.1080/03007995.2017.1391759. Epub 2017 Nov 16.


Dipeptidyl Peptidase-4 Inhibition With Saxagliptin Ameliorates Angiotensin II-Induced Cardiac Diastolic Dysfunction in Male Mice.

Brown SM, Smith CE, Meuth AI, Khan M, Aroor AR, Cleeton HM, Meininger GA, Sowers JR, DeMarco VG, Chandrasekar B, Nistala R, Bender SB.

Endocrinology. 2017 Oct 1;158(10):3592-3604. doi: 10.1210/en.2017-00416.


Uric acid promotes vascular stiffness, maladaptive inflammatory responses and proteinuria in western diet fed mice.

Aroor AR, Jia G, Habibi J, Sun Z, Ramirez-Perez FI, Brady B, Chen D, Martinez-Lemus LA, Manrique C, Nistala R, Whaley-Connell AT, Demarco VG, Meininger GA, Sowers JR.

Metabolism. 2017 Sep;74:32-40. doi: 10.1016/j.metabol.2017.06.006. Epub 2017 Jun 21.


Rationale, design and baseline characteristics of the CANagliflozin cardioVascular Assessment Study-Renal (CANVAS-R): A randomized, placebo-controlled trial.

Neal B, Perkovic V, Matthews DR, Mahaffey KW, Fulcher G, Meininger G, Erondu N, Desai M, Shaw W, Vercruysse F, Yee J, Deng H, de Zeeuw D; CANVAS-R Trial Collaborative Group.

Diabetes Obes Metab. 2017 Mar;19(3):387-393. doi: 10.1111/dom.12829. Epub 2017 Jan 25.


N-Cadherin, a novel and rapidly remodelling site involved in vasoregulation of small cerebral arteries.

Sun Z, Li M, Li Z, Hill MA, Meininger GA.

J Physiol. 2017 Mar 15;595(6):1987-2000. doi: 10.1113/JP272995. Epub 2017 Feb 7.


Nonenzymatic glycation interferes with fibronectin-integrin interactions in vascular smooth muscle cells.

Dhar S, Sun Z, Meininger GA, Hill MA.

Microcirculation. 2017 Apr;24(3). doi: 10.1111/micc.12347.


Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells.

Wang X, Nichols L, Grunz-Borgmann EA, Sun Z, Meininger GA, Domeier TL, Baines CP, Parrish AR.

Toxicol Lett. 2017 Jan 15;266:56-64. doi: 10.1016/j.toxlet.2016.11.021. Epub 2016 Dec 15.


Longer-term safety and tolerability of canagliflozin in patients with type 2 diabetes: a pooled analysis.

Qiu R, Balis D, Xie J, Davies MJ, Desai M, Meininger G.

Curr Med Res Opin. 2017 Mar;33(3):553-562. doi: 10.1080/03007995.2016.1271780. Epub 2017 Jan 4.


"Small Blood Vessels: Big Health Problems?": Scientific Recommendations of the National Institutes of Health Workshop.

Bosetti F, Galis ZS, Bynoe MS, Charette M, Cipolla MJ, Del Zoppo GJ, Gould D, Hatsukami TS, Jones TL, Koenig JI, Lutty GA, Maric-Bilkan C, Stevens T, Tolunay HE, Koroshetz W; “Small Blood Vessels: Big Health Problems” Workshop Participants.

J Am Heart Assoc. 2016 Nov 4;5(11). pii: e004389. No abstract available.


Canagliflozin: Efficacy and Safety in Combination with Metformin Alone or with Other Antihyperglycemic Agents in Type 2 Diabetes.

Qiu R, Balis D, Capuano G, Xie J, Meininger G.

Diabetes Ther. 2016 Dec;7(4):659-678. Epub 2016 Oct 12. Review.


Small artery mechanobiology: Roles of cellular and non-cellular elements.

Hill MA, Meininger GA.

Microcirculation. 2016 Nov;23(8):611-613. doi: 10.1111/micc.12323. Review.


Canagliflozin Slows Progression of Renal Function Decline Independently of Glycemic Effects.

Heerspink HJ, Desai M, Jardine M, Balis D, Meininger G, Perkovic V.

J Am Soc Nephrol. 2017 Jan;28(1):368-375. doi: 10.1681/ASN.2016030278. Epub 2016 Aug 18.

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