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Items: 14


The R753Q polymorphism in Toll-like receptor 2 (TLR2) attenuates innate immune responses to mycobacteria and impairs MyD88 adapter recruitment to TLR2.

Pattabiraman G, Panchal R, Medvedev AE.

J Biol Chem. 2017 Jun 23;292(25):10685-10695. doi: 10.1074/jbc.M117.784470. Epub 2017 Apr 25.


Pellino-3 promotes endotoxin tolerance and acts as a negative regulator of TLR2 and TLR4 signaling.

Murphy MB, Xiong Y, Pattabiraman G, Manavalan TT, Qiu F, Medvedev AE.

J Leukoc Biol. 2015 Dec;98(6):963-74. doi: 10.1189/jlb.2VMA0515-229RR. Epub 2015 Aug 26.


Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance.

Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev AE.

J Biol Chem. 2015 Jul 31;290(31):19218-32. doi: 10.1074/jbc.M115.640128. Epub 2015 Jun 16.


IRAK4 kinase activity is not required for induction of endotoxin tolerance but contributes to TLR2-mediated tolerance.

Xiong Y, Pennini M, Vogel SN, Medvedev AE.

J Leukoc Biol. 2013 Aug;94(2):291-300. doi: 10.1189/jlb.0812401. Epub 2013 May 21.


R753Q polymorphism inhibits Toll-like receptor (TLR) 2 tyrosine phosphorylation, dimerization with TLR6, and recruitment of myeloid differentiation primary response protein 88.

Xiong Y, Song C, Snyder GA, Sundberg EJ, Medvedev AE.

J Biol Chem. 2012 Nov 2;287(45):38327-37. doi: 10.1074/jbc.M112.375493. Epub 2012 Sep 19.


Pathogenic Old World arenaviruses inhibit TLR2/Mal-dependent proinflammatory cytokines in vitro.

Hayes MW, Carrion R Jr, Nunneley J, Medvedev AE, Salvato MS, Lukashevich IS.

J Virol. 2012 Jul;86(13):7216-26. doi: 10.1128/JVI.06508-11. Epub 2012 Apr 24.


Involvement of TLR2 and TLR4 in cell responses to Rickettsia akari.

Quevedo-Diaz MA, Song C, Xiong Y, Chen H, Wahl LM, Radulovic S, Medvedev AE.

J Leukoc Biol. 2010 Oct;88(4):675-85. doi: 10.1189/jlb.1009674. Epub 2010 Jul 8.


Involvement of TLR2 and TLR4 in inflammatory immune responses induced by fine and coarse ambient air particulate matter.

Shoenfelt J, Mitkus RJ, Zeisler R, Spatz RO, Powell J, Fenton MJ, Squibb KA, Medvedev AE.

J Leukoc Biol. 2009 Aug;86(2):303-12. doi: 10.1189/jlb.1008587.


Role of TLR4 tyrosine phosphorylation in signal transduction and endotoxin tolerance.

Medvedev AE, Piao W, Shoenfelt J, Rhee SH, Chen H, Basu S, Wahl LM, Fenton MJ, Vogel SN.

J Biol Chem. 2007 Jun 1;282(22):16042-53. Epub 2007 Mar 28.


Induction of in vitro reprogramming by Toll-like receptor (TLR)2 and TLR4 agonists in murine macrophages: effects of TLR "homotolerance" versus "heterotolerance" on NF-kappa B signaling pathway components.

Dobrovolskaia MA, Medvedev AE, Thomas KE, Cuesta N, Toshchakov V, Ren T, Cody MJ, Michalek SM, Rice NR, Vogel SN.

J Immunol. 2003 Jan 1;170(1):508-19.


Induction of tolerance to lipopolysaccharide and mycobacterial components in Chinese hamster ovary/CD14 cells is not affected by overexpression of Toll-like receptors 2 or 4.

Medvedev AE, Henneke P, Schromm A, Lien E, Ingalls R, Fenton MJ, Golenbock DT, Vogel SN.

J Immunol. 2001 Aug 15;167(4):2257-67.

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