Format

Send to

Choose Destination

See 1 citation found by title matching your search:

J Soc Gynecol Investig. 2002 Sep-Oct;9(5):308-12.

Mechanism of increased maternal serum total activin a and inhibin a in preeclampsia.

Author information

1
Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, and Department of Pathology, Brown University, Providence, Rhode Island 02905, USA. hsilver@whri.org

Abstract

OBJECTIVE:

To determine whether increased levels of maternal serum total activin A and inhibin A in preeclampsia are related to total blood volume, urinary clearance, or placental production.

STUDY DESIGN:

Activin A and inhibin A levels were measured in preeclamptic subjects and matched normotensive gravidas. In a subset of preeclamptic subjects (n = 21) and controls (n = 30), we performed blood volume studies. In an overlapping subset of preeclamptic subjects (n = 56), creatinine clearance results were available. Placental tissue was obtained from six preeclamptics and matched normotensive gravida for analysis of activin A and inhibin A mRNA expression.

RESULTS:

Maternal serum levels of inhibin A but not activin A were significantly negatively correlated with blood volume in preeclampsia (r(2) =.26, P =.017, and r(2) =.02, P =.44, respectively). Levels of both proteins were negatively correlated to creatinine clearance (r(2) =.29, P <.0001, and r(2) =.15, P =.003, respectively). Placental mRNA expression for both the alpha and betaA subunits was increased in preeclampsia (P =.038 and.049, respectively).

CONCLUSION:

Although placental mRNA expression of the subunits for both analytes is increased in preeclampsia, the increased levels of activin A appear to be more specifically a reflection of increased placental production than do the increased levels of inhibin A.

PMID:
12383916
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center