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Integrating host response and unbiased microbe detection for lower respiratory tract infection diagnosis in critically ill adults.

Langelier C, Kalantar KL, Moazed F, Wilson MR, Crawford ED, Deiss T, Belzer A, Bolourchi S, Caldera S, Fung M, Jauregui A, Malcolm K, Lyden A, Khan L, Vessel K, Quan J, Zinter M, Chiu CY, Chow ED, Wilson J, Miller S, Matthay MA, Pollard KS, Christenson S, Calfee CS, DeRisi JL.

Proc Natl Acad Sci U S A. 2018 Nov 27. pii: 201809700. doi: 10.1073/pnas.1809700115. [Epub ahead of print]


Treatment with allogeneic mesenchymal stromal cells for moderate to severe acute respiratory distress syndrome (START study): a randomised phase 2a safety trial.

Matthay MA, Calfee CS, Zhuo H, Thompson BT, Wilson JG, Levitt JE, Rogers AJ, Gotts JE, Wiener-Kronish JP, Bajwa EK, Donahoe MP, McVerry BJ, Ortiz LA, Exline M, Christman JW, Abbott J, Delucchi KL, Caballero L, McMillan M, McKenna DH, Liu KD.

Lancet Respir Med. 2018 Nov 16. pii: S2213-2600(18)30418-1. doi: 10.1016/S2213-2600(18)30418-1. [Epub ahead of print]


Prospective Assessment of the Feasibility of a Trial of Low Tidal Volume Ventilation for Patients with Acute Respiratory Failure.

Lanspa MJ, Gong MN, Schoenfeld DA, Lee KT, Grissom CK, Hou PC, Serpa-Neto A, Brown SM, Iwashyna TJ, Yealy DM, Hough CL, Brower RG, Calfee CS, Hyzy RC, Matthay MA, Miller RR 3rd, Steingrub JS, Thompson BT, Miller CD, Clemmer TP, Hendey GW, Huang DT, Mathews KS, Qadir N, Tidswell M; National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung injury (PETAL) Clinical Trials Network.

Ann Am Thorac Soc. 2018 Nov 8. doi: 10.1513/AnnalsATS.201807-459OC. [Epub ahead of print]


The Continued Need for Clinical Trials in Deceased Organ Donor Management.

Niemann CU, Matthay MA, Ware LB.

Transplantation. 2018 Nov 5. doi: 10.1097/TP.0000000000002512. [Epub ahead of print] No abstract available.


Therapeutic potential of mesenchymal stromal cells in the treatment of ARDS.

Huppert LA, Liu KD, Matthay MA.

Transfusion. 2018 Nov 1. doi: 10.1111/trf.14835. [Epub ahead of print] No abstract available.


AIMing Immunomodulation Therapy at Sepsis.

Leligdowicz A, Matthay MA.

Am J Respir Cell Mol Biol. 2018 Oct 26. doi: 10.1165/rcmb.2018-0338ED. [Epub ahead of print] No abstract available.


Plasma angiopoietin-2 as a potential causal marker in sepsis-associated ARDS development: evidence from Mendelian randomization and mediation analysis.

Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ.

Intensive Care Med. 2018 Nov;44(11):1849-1858. doi: 10.1007/s00134-018-5328-0. Epub 2018 Oct 21.


Identification of Acute Kidney Injury Sub-phenotypes with Differing Molecular Signatures and Response to Vasopressin Therapy.

Bhatraju PK, Zelnick LR, Herting J, Katz R, Mikacenic C, Kosamo S, Morrell ED, Robinson-Cohen C, Calfee CS, Christie JD, Liu KD, Matthay MA, Hahn WO, Dmyterko V, Slivinski NSJ, Russell JA, Walley KR, Christiani DC, Liles WC, Himmelfarb J, Wurfel MM.

Am J Respir Crit Care Med. 2018 Oct 18. doi: 10.1164/rccm.201807-1346OC. [Epub ahead of print]


Latent class analysis of ARDS subphenotypes: a secondary analysis of the statins for acutely injured lungs from sepsis (SAILS) study.

Sinha P, Delucchi KL, Thompson BT, McAuley DF, Matthay MA, Calfee CS; NHLBI ARDS Network.

Intensive Care Med. 2018 Nov;44(11):1859-1869. doi: 10.1007/s00134-018-5378-3. Epub 2018 Oct 5.


Variability in Pediatric Ideal Body Weight Calculation: Implications for Lung-Protective Mechanical Ventilation Strategies in Pediatric Acute Respiratory Distress Syndrome.

Ward SL, Quinn CM, Steurer MA, Liu KD, Flori HR, Matthay MA.

Pediatr Crit Care Med. 2018 Dec;19(12):e643-e652. doi: 10.1097/PCC.0000000000001740.


Beyond Low Tidal Volume Ventilation: Treatment Adjuncts for Severe Respiratory Failure in Acute Respiratory Distress Syndrome.

Fielding-Singh V, Matthay MA, Calfee CS.

Crit Care Med. 2018 Nov;46(11):1820-1831. doi: 10.1097/CCM.0000000000003406.


Pulmonary mechanics and gas exchange characteristics in uncommon etiologies of acute respiratory distress syndrome.

Kallet RH, Ho K, Lipnick MS, Matthay MA.

J Thorac Dis. 2018 Aug;10(8):5030-5038. doi: 10.21037/jtd.2018.07.78.


Physiological Analysis and Clinical Performance of the Ventilatory Ratio in Acute Respiratory Distress Syndrome.

Sinha P, Calfee CS, Beitler JR, Soni N, Ho K, Matthay MA, Kallet RH.

Am J Respir Crit Care Med. 2018 Sep 13. doi: 10.1164/rccm.201804-0692OC. [Epub ahead of print]


Meta-Analysis of Preclinical Studies of Fibrinolytic Therapy for Acute Lung Injury.

Liu C, Ma Y, Su Z, Zhao R, Zhao X, Nie HG, Xu P, Zhu L, Zhang M, Li X, Zhang X, Matthay MA, Ji HL.

Front Immunol. 2018 Aug 20;9:1898. doi: 10.3389/fimmu.2018.01898. eCollection 2018.


Assessment of industry data on pulmonary and immunosuppressive effects of IQOS.

Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J.

Tob Control. 2018 Nov;27(Suppl 1):s20-s25. doi: 10.1136/tobaccocontrol-2018-054296. Epub 2018 Aug 29.


Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome.

Mi MY, Matthay MA, Morris AH.

N Engl J Med. 2018 Aug 30;379(9):884-887. doi: 10.1056/NEJMclde1804601. No abstract available.


Effects of bone marrow-derived mesenchymal stromal cells on gene expression in human alveolar type II cells exposed to TNF-α, IL-1β, and IFN-γ.

Schwede M, Wilfong EM, Zemans RL, Lee PJ, Dos Santos C, Fang X, Matthay MA.

Physiol Rep. 2018 Aug;6(16):e13831. doi: 10.14814/phy2.13831.


Effect of Rosuvastatin on Acute Kidney Injury in Sepsis-Associated Acute Respiratory Distress Syndrome.

Hsu RK, Truwit JD, Matthay MA, Levitt JE, Thompson BT, Liu KD.

Can J Kidney Health Dis. 2018 Aug 2;5:2054358118789158. doi: 10.1177/2054358118789158. eCollection 2018.


Early Plasma Matrix Metalloproteinase Profiles: A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome.

Zinter MS, Delucchi KL, Kong MY, Orwoll BE, Spicer AS, Lim MJ, Alkhouli MF, Ratiu AE, McKenzie AV, McQuillen PS, Dvorak CC, Calfee CS, Matthay MA, Sapru A.

Am J Respir Crit Care Med. 2018 Aug 16. doi: 10.1164/rccm.201804-0678OC. [Epub ahead of print]


Interleukin-1 Receptor Antagonist Is Associated With Pediatric Acute Respiratory Distress Syndrome and Worse Outcomes in Children With Acute Respiratory Failure.

Dahmer MK, Quasney MW, Sapru A, Gildengorin G, Curley MAQ, Matthay MA, Flori H; BALI and RESTORE Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.

Pediatr Crit Care Med. 2018 Oct;19(10):930-938. doi: 10.1097/PCC.0000000000001680.


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