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Items: 1 to 20 of 47

1.

Novel carboxylate-based glycolipids: TLR4 antagonism, MD-2 binding and self-assembly properties.

Cochet F, Facchini FA, Zaffaroni L, Billod JM, Coelho H, Holgado A, Braun H, Beyaert R, Jerala R, Jimenez-Barbero J, Martin-Santamaria S, Peri F.

Sci Rep. 2019 Jan 29;9(1):919. doi: 10.1038/s41598-018-37421-w.

2.

Antagonistic Pleiotropy in the Bifunctional Surface Protein FadL (OmpP1) during Adaptation of Haemophilus influenzae to Chronic Lung Infection Associated with Chronic Obstructive Pulmonary Disease.

Moleres J, Fernández-Calvet A, Ehrlich RL, Martí S, Pérez-Regidor L, Euba B, Rodríguez-Arce I, Balashov S, Cuevas E, Liñares J, Ardanuy C, Martín-Santamaría S, Ehrlich GD, Mell JC, Garmendia J.

MBio. 2018 Sep 25;9(5). pii: e01176-18. doi: 10.1128/mBio.01176-18.

3.

Insights into the key determinants of membrane protein topology enable the identification of new monotopic folds.

Entova S, Billod JM, Swiecicki JM, Martín-Santamaría S, Imperiali B.

Elife. 2018 Aug 31;7. pii: e40889. doi: 10.7554/eLife.40889.

4.

Bradyrhizobium Lipid A: Immunological Properties and Molecular Basis of Its Binding to the Myeloid Differentiation Protein-2/Toll-Like Receptor 4 Complex.

Lembo-Fazio L, Billod JM, Di Lorenzo F, Paciello I, Pallach M, Vaz-Francisco S, Holgado A, Beyaert R, Fresno M, Shimoyama A, Lanzetta R, Fukase K, Gully D, Giraud E, Martín-Santamaría S, Bernardini ML, Silipo A.

Front Immunol. 2018 Aug 14;9:1888. doi: 10.3389/fimmu.2018.01888. eCollection 2018.

5.

Structure-Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists.

Facchini FA, Zaffaroni L, Minotti A, Rapisarda S, Calabrese V, Forcella M, Fusi P, Airoldi C, Ciaramelli C, Billod JM, Schromm AB, Braun H, Palmer C, Beyaert R, Lapenta F, Jerala R, Pirianov G, Martin-Santamaria S, Peri F.

J Med Chem. 2018 Apr 12;61(7):2895-2909. doi: 10.1021/acs.jmedchem.7b01803. Epub 2018 Mar 12.

6.

Amphiphilic Guanidinocalixarenes Inhibit Lipopolysaccharide (LPS)- and Lectin-Stimulated Toll-like Receptor 4 (TLR4) Signaling.

Sestito SE, Facchini FA, Morbioli I, Billod JM, Martin-Santamaria S, Casnati A, Sansone F, Peri F.

J Med Chem. 2017 Jun 22;60(12):4882-4892. doi: 10.1021/acs.jmedchem.7b00095. Epub 2017 May 15.

PMID:
28471658
7.

Antibiotic Capture by Bacterial Lipocalins Uncovers an Extracellular Mechanism of Intrinsic Antibiotic Resistance.

El-Halfawy OM, Klett J, Ingram RJ, Loutet SA, Murphy ME, Martín-Santamaría S, Valvano MA.

MBio. 2017 Mar 14;8(2). pii: e00225-17. doi: 10.1128/mBio.00225-17.

8.

Virtual Screening Approaches towards the Discovery of Toll-Like Receptor Modulators.

Pérez-Regidor L, Zarioh M, Ortega L, Martín-Santamaría S.

Int J Mol Sci. 2016 Sep 9;17(9). pii: E1508. doi: 10.3390/ijms17091508. Review.

9.

Computational Approaches to Toll-Like Receptor 4 Modulation.

Billod JM, Lacetera A, Guzmán-Caldentey J, Martín-Santamaría S.

Molecules. 2016 Jul 30;21(8). pii: E994. doi: 10.3390/molecules21080994. Review.

10.

Glycomimetics Targeting Glycosyltransferases: Synthetic, Computational and Structural Studies of Less-Polar Conjugates.

Ghirardello M, de Las Rivas M, Lacetera A, Delso I, Lira-Navarrete E, Tejero T, Martín-Santamaría S, Hurtado-Guerrero R, Merino P.

Chemistry. 2016 May 17;22(21):7215-24. doi: 10.1002/chem.201600467. Epub 2016 Apr 13.

PMID:
27071848
11.

Glycolipid-based TLR4 Modulators and Fluorescent Probes: Rational Design, Synthesis, and Biological Properties.

Ciaramelli C, Calabrese V, Sestito SE, Pérez-Regidor L, Klett J, Oblak A, Jerala R, Piazza M, Martín-Santamaría S, Peri F.

Chem Biol Drug Des. 2016 Aug;88(2):217-29. doi: 10.1111/cbdd.12749. Epub 2016 Mar 11.

PMID:
26896420
12.

Molecular Basis of the Functional Differences between Soluble Human Versus Murine MD-2: Role of Val135 in Transfer of Lipopolysaccharide from CD14 to MD-2.

Vašl J, Oblak A, Peternelj TT, Klett J, Martín-Santamaría S, Gioannini TL, Weiss JP, Jerala R.

J Immunol. 2016 Mar 1;196(5):2309-18. doi: 10.4049/jimmunol.1502074. Epub 2016 Jan 29.

13.

Activation of Human Toll-like Receptor 4 (TLR4)·Myeloid Differentiation Factor 2 (MD-2) by Hypoacylated Lipopolysaccharide from a Clinical Isolate of Burkholderia cenocepacia.

Di Lorenzo F, Kubik Ł, Oblak A, Lorè NI, Cigana C, Lanzetta R, Parrilli M, Hamad MA, De Soyza A, Silipo A, Jerala R, Bragonzi A, Valvano MA, Martín-Santamaría S, Molinaro A.

J Biol Chem. 2015 Aug 28;290(35):21305-19. doi: 10.1074/jbc.M115.649087. Epub 2015 Jul 9.

14.

Conformational Plasticity in Glycomimetics: Fluorocarbamethyl-L-idopyranosides Mimic the Intrinsic Dynamic Behaviour of Natural Idose Rings.

Unione L, Xu B, Díaz D, Martín-Santamaría S, Poveda A, Sardinha J, Rauter AP, Blériot Y, Zhang Y, Cañada FJ, Sollogoub M, Jiménez-Barbero J.

Chemistry. 2015 Jul 13;21(29):10513-21. doi: 10.1002/chem.201501249. Epub 2015 Jun 10.

PMID:
26096911
15.

Modulation of toll-like receptor 4. Insights from x-ray crystallography and molecular modeling.

Klett J, Reeves J, Oberhauser N, Pérez-Regidor L, Martín-Santamaria S.

Curr Top Med Chem. 2014;14(23):2672-83. Review.

PMID:
25515751
16.

Editorial :Chemistry Bordering Biology: highlights from the XXXIV Biennial Meeting of the RSEQ.

Goya P, Martin-Santamaria S.

Curr Top Med Chem. 2014;14(23):2625-6. No abstract available.

PMID:
25515743
17.

Chemistry of lipid A: at the heart of innate immunity.

Molinaro A, Holst O, Di Lorenzo F, Callaghan M, Nurisso A, D'Errico G, Zamyatina A, Peri F, Berisio R, Jerala R, Jiménez-Barbero J, Silipo A, Martín-Santamaría S.

Chemistry. 2015 Jan 7;21(2):500-19. doi: 10.1002/chem.201403923. Epub 2014 Oct 29. Review.

PMID:
25353096
18.

Serine versus threonine glycosylation with α-O-GalNAc: unexpected selectivity in their molecular recognition with lectins.

Madariaga D, Martínez-Sáez N, Somovilla VJ, García-García L, Berbis MÁ, Valero-Gónzalez J, Martín-Santamaría S, Hurtado-Guerrero R, Asensio JL, Jiménez-Barbero J, Avenoza A, Busto JH, Corzana F, Peregrina JM.

Chemistry. 2014 Sep 22;20(39):12616-27. doi: 10.1002/chem.201403700. Epub 2014 Aug 8.

PMID:
25111627
19.

gem-Difluorocarbadisaccharides: restoring the exo-anomeric effect.

Xu B, Unione L, Sardinha J, Wu S, Ethève-Quelquejeu M, Pilar Rauter A, Blériot Y, Zhang Y, Martín-Santamaría S, Díaz D, Jiménez-Barbero J, Sollogoub M.

Angew Chem Int Ed Engl. 2014 Sep 1;53(36):9597-602. doi: 10.1002/anie.201405008. Epub 2014 Jul 15.

PMID:
25044775
20.

Modulation of CD14 and TLR4·MD-2 activities by a synthetic lipid A mimetic.

Cighetti R, Ciaramelli C, Sestito SE, Zanoni I, Kubik Ł, Ardá-Freire A, Calabrese V, Granucci F, Jerala R, Martín-Santamaría S, Jiménez-Barbero J, Peri F.

Chembiochem. 2014 Jan 24;15(2):250-8. doi: 10.1002/cbic.201300588. Epub 2013 Dec 12.

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