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DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1.

Ribeiro-Silva C, Aydin ÖZ, Mesquita-Ribeiro R, Slyskova J, Helfricht A, Marteijn JA, Hoeijmakers JHJ, Lans H, Vermeulen W.

Nat Commun. 2018 Oct 4;9(1):4067. doi: 10.1038/s41467-018-06402-y.


What happens at the lesion does not stay at the lesion: Transcription-coupled nucleotide excision repair and the effects of DNA damage on transcription in cis and trans.

Geijer ME, Marteijn JA.

DNA Repair (Amst). 2018 Nov;71:56-68. doi: 10.1016/j.dnarep.2018.08.007. Epub 2018 Aug 23. Review.


DNA damage-induced replication stress results in PA200-proteasome-mediated degradation of acetylated histones.

Mandemaker IK, Geijer ME, Kik I, Bezstarosti K, Rijkers E, Raams A, Janssens RC, Lans H, Hoeijmakers JH, Demmers JA, Vermeulen W, Marteijn JA.

EMBO Rep. 2018 Oct;19(10). pii: e45566. doi: 10.15252/embr.201745566. Epub 2018 Aug 13.


The transcription-coupled DNA repair-initiating protein CSB promotes XRCC1 recruitment to oxidative DNA damage.

Menoni H, Wienholz F, Theil AF, Janssens RC, Lans H, Campalans A, Radicella JP, Marteijn JA, Vermeulen W.

Nucleic Acids Res. 2018 Sep 6;46(15):7747-7756. doi: 10.1093/nar/gky579.


Live-cell analysis of endogenous GFP-RPB1 uncovers rapid turnover of initiating and promoter-paused RNA Polymerase II.

Steurer B, Janssens RC, Geverts B, Geijer ME, Wienholz F, Theil AF, Chang J, Dealy S, Pothof J, van Cappellen WA, Houtsmuller AB, Marteijn JA.

Proc Natl Acad Sci U S A. 2018 May 8;115(19):E4368-E4376. doi: 10.1073/pnas.1717920115. Epub 2018 Apr 9.


DNA damage-induced histone H1 ubiquitylation is mediated by HUWE1 and stimulates the RNF8-RNF168 pathway.

Mandemaker IK, van Cuijk L, Janssens RC, Lans H, Bezstarosti K, Hoeijmakers JH, Demmers JA, Vermeulen W, Marteijn JA.

Sci Rep. 2017 Nov 10;7(1):15353. doi: 10.1038/s41598-017-15194-y.


Trichothiodystrophy causative TFIIEβ mutation affects transcription in highly differentiated tissue.

Theil AF, Mandemaker IK, van den Akker E, Swagemakers SMA, Raams A, Wüst T, Marteijn JA, Giltay JC, Colombijn RM, Moog U, Kotzaeridou U, Ghazvini M, von Lindern M, Hoeijmakers JHJ, Jaspers NGJ, van der Spek PJ, Vermeulen W.

Hum Mol Genet. 2017 Dec 1;26(23):4689-4698. doi: 10.1093/hmg/ddx351.


Noncanonical ATM Activation and Signaling in Response to Transcription-Blocking DNA Damage.

Marteijn JA, Vermeulen W, Tresini M.

Methods Mol Biol. 2017;1599:347-361. doi: 10.1007/978-1-4939-6955-5_25.


Traveling Rocky Roads: The Consequences of Transcription-Blocking DNA Lesions on RNA Polymerase II.

Steurer B, Marteijn JA.

J Mol Biol. 2017 Oct 27;429(21):3146-3155. doi: 10.1016/j.jmb.2016.11.006. Epub 2016 Nov 13. Review.


Bidirectional coupling of splicing and ATM signaling in response to transcription-blocking DNA damage.

Tresini M, Marteijn JA, Vermeulen W.

RNA Biol. 2016;13(3):272-8. doi: 10.1080/15476286.2016.1142039. Epub 2016 Feb 25.


Check, Check …Triple Check: Multi-Step DNA Lesion Identification by Nucleotide Excision Repair.

Marteijn JA, Hoeijmakers JH, Vermeulen W.

Mol Cell. 2015 Sep 17;59(6):885-6. doi: 10.1016/j.molcel.2015.09.007.


SUMO and ubiquitin-dependent XPC exchange drives nucleotide excision repair.

van Cuijk L, van Belle GJ, Turkyilmaz Y, Poulsen SL, Janssens RC, Theil AF, Sabatella M, Lans H, Mailand N, Houtsmuller AB, Vermeulen W, Marteijn JA.

Nat Commun. 2015 Jul 7;6:7499. doi: 10.1038/ncomms8499.


The core spliceosome as target and effector of non-canonical ATM signalling.

Tresini M, Warmerdam DO, Kolovos P, Snijder L, Vrouwe MG, Demmers JA, van IJcken WF, Grosveld FG, Medema RH, Hoeijmakers JH, Mullenders LH, Vermeulen W, Marteijn JA.

Nature. 2015 Jul 2;523(7558):53-8. doi: 10.1038/nature14512. Epub 2015 Jun 24.


Differential binding kinetics of replication protein A during replication and the pre- and post-incision steps of nucleotide excision repair.

Gourdin AM, van Cuijk L, Tresini M, Luijsterburg MS, Nigg AL, Giglia-Mari G, Houtsmuller AB, Vermeulen W, Marteijn JA.

DNA Repair (Amst). 2014 Dec;24:46-56. doi: 10.1016/j.dnarep.2014.09.013. Epub 2014 Oct 16.


Ubiquitin at work: the ubiquitous regulation of the damage recognition step of NER.

van Cuijk L, Vermeulen W, Marteijn JA.

Exp Cell Res. 2014 Nov 15;329(1):101-9. doi: 10.1016/j.yexcr.2014.07.018. Epub 2014 Jul 22. Review.


Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcription.

Aydin ÖZ, Marteijn JA, Ribeiro-Silva C, Rodríguez López A, Wijgers N, Smeenk G, van Attikum H, Poot RA, Vermeulen W, Lans H.

Nucleic Acids Res. 2014 Jul;42(13):8473-85. doi: 10.1093/nar/gku565. Epub 2014 Jul 2.


Understanding nucleotide excision repair and its roles in cancer and ageing.

Marteijn JA, Lans H, Vermeulen W, Hoeijmakers JH.

Nat Rev Mol Cell Biol. 2014 Jul;15(7):465-81. doi: 10.1038/nrm3822. Review.


Gearing up chromatin: A role for chromatin remodeling during the transcriptional restart upon DNA damage.

Mandemaker IK, Vermeulen W, Marteijn JA.

Nucleus. 2014 May-Jun;5(3):203-10. doi: 10.4161/nucl.29085. Epub 2014 May 8. Review.


Enhanced chromatin dynamics by FACT promotes transcriptional restart after UV-induced DNA damage.

Dinant C, Ampatziadis-Michailidis G, Lans H, Tresini M, Lagarou A, Grosbart M, Theil AF, van Cappellen WA, Kimura H, Bartek J, Fousteri M, Houtsmuller AB, Vermeulen W, Marteijn JA.

Mol Cell. 2013 Aug 22;51(4):469-79. doi: 10.1016/j.molcel.2013.08.007.

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