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Hepatitis B vaccination using a dissolvable microneedle patch is immunogenic in mice and rhesus macaques.

Perez Cuevas MB, Kodani M, Choi Y, Joyce J, O'Connor SM, Kamili S, Prausnitz MR.

Bioeng Transl Med. 2018 Aug 27;3(3):186-196. doi: 10.1002/btm2.10098. eCollection 2018 Sep.


Vaccination by microneedle patch with inactivated respiratory syncytial virus and monophosphoryl lipid A enhances the protective efficacy and diminishes inflammatory disease after challenge.

Park S, Lee Y, Kwon YM, Lee YT, Kim KH, Ko EJ, Jung JH, Song M, Graham B, Prausnitz MR, Kang SM.

PLoS One. 2018 Oct 26;13(10):e0205071. doi: 10.1371/journal.pone.0205071. eCollection 2018.


Enhanced Immune Responses Conferring Cross-Protection by Skin Vaccination With a Tri-Component Influenza Vaccine Using a Microneedle Patch.

Zhu W, Li S, Wang C, Yu G, Prausnitz MR, Wang BZ.

Front Immunol. 2018 Jul 30;9:1705. doi: 10.3389/fimmu.2018.01705. eCollection 2018.


Heterosubtypic influenza protection elicited by double-layered polypeptide nanoparticles in mice.

Deng L, Chang TZ, Wang Y, Li S, Wang S, Matsuyama S, Yu G, Compans RW, Li JD, Prausnitz MR, Champion JA, Wang BZ.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7758-E7767. doi: 10.1073/pnas.1805713115. Epub 2018 Jul 31.


Intradermal immunization by Ebola virus GP subunit vaccines using microneedle patches protects mice against lethal EBOV challenge.

Liu Y, Ye L, Lin F, Gomaa Y, Flyer D, Carrion R Jr, Patterson JL, Prausnitz MR, Smith G, Glenn G, Wu H, Compans RW, Yang C.

Sci Rep. 2018 Jul 25;8(1):11193. doi: 10.1038/s41598-018-29135-w.


Intradermal Vaccination With Adjuvanted Ebola Virus Soluble Glycoprotein Subunit Vaccine by Microneedle Patches Protects Mice Against Lethal Ebola Virus Challenge.

Liu Y, Ye L, Lin F, Gomaa Y, Flyer D, Carrion R Jr, Patterson JL, Prausnitz MR, Smith G, Glenn G, Wu H, Compans RW, Yang C.

J Infect Dis. 2018 Jun 8. doi: 10.1093/infdis/jiy267. [Epub ahead of print]


Effect of laser fluence, nanoparticle concentration and total energy input per cell on photoporation of cells.

Holguin SY, Thadhani NN, Prausnitz MR.

Nanomedicine. 2018 Jul;14(5):1667-1677. doi: 10.1016/j.nano.2018.04.015. Epub 2018 Apr 30.


Drug delivery using microneedle patches: not just for skin.

Lee JW, Prausnitz MR.

Expert Opin Drug Deliv. 2018 Jun;15(6):541-543. doi: 10.1080/17425247.2018.1471059. Epub 2018 May 7. No abstract available.


A Microneedle Patch for Measles and Rubella Vaccination Is Immunogenic and Protective in Infant Rhesus Macaques.

Joyce JC, Carroll TD, Collins ML, Chen MH, Fritts L, Dutra JC, Rourke TL, Goodson JL, McChesney MB, Prausnitz MR, Rota PA.

J Infect Dis. 2018 Jun 5;218(1):124-132. doi: 10.1093/infdis/jiy139.


Targeted Drug Delivery in the Suprachoroidal Space by Swollen Hydrogel Pushing.

Jung JH, Desit P, Prausnitz MR.

Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):2069-2079. doi: 10.1167/iovs.17-23758.


Mechanisms of sampling interstitial fluid from skin using a microneedle patch.

Samant PP, Prausnitz MR.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4583-4588. doi: 10.1073/pnas.1716772115. Epub 2018 Apr 16.


The suprachoroidal space as a route of administration to the posterior segment of the eye.

Chiang B, Jung JH, Prausnitz MR.

Adv Drug Deliv Rev. 2018 Feb 15;126:58-66. doi: 10.1016/j.addr.2018.03.001. Epub 2018 Mar 12. Review.


Ocular drug delivery targeted by iontophoresis in the suprachoroidal space using a microneedle.

Jung JH, Chiang B, Grossniklaus HE, Prausnitz MR.

J Control Release. 2018 May 10;277:14-22. doi: 10.1016/j.jconrel.2018.03.001. Epub 2018 Mar 2.


Stable incorporation of GM-CSF into dissolvable microneedle patch improves skin vaccination against influenza.

Littauer EQ, Mills LK, Brock N, Esser ES, Romanyuk A, Pulit-Penaloza JA, Vassilieva EV, Beaver JT, Antao O, Krammer F, Compans RW, Prausnitz MR, Skountzou I.

J Control Release. 2018 Apr 28;276:1-16. doi: 10.1016/j.jconrel.2018.02.033. Epub 2018 Feb 26.


Human Suction Blister Fluid Composition Determined Using High-Resolution Metabolomics.

Niedzwiecki MM, Samant P, Walker DI, Tran V, Jones DP, Prausnitz MR, Miller GW.

Anal Chem. 2018 Mar 20;90(6):3786-3792. doi: 10.1021/acs.analchem.7b04073. Epub 2018 Feb 27.


Skin immunization by microneedle patch overcomes statin-induced suppression of immune responses to influenza vaccine.

Vassilieva EV, Wang S, Li S, Prausnitz MR, Compans RW.

Sci Rep. 2017 Dec 19;7(1):17855. doi: 10.1038/s41598-017-18140-0.


Photoporation Using Carbon Nanotubes for Intracellular Delivery of Molecules and Its Relationship to Photoacoustic Pressure.

Holguin SY, Gray MD, Joseph P, Thadhani NN, Prausnitz MR.

Adv Healthc Mater. 2018 Mar;7(5). doi: 10.1002/adhm.201701007. Epub 2017 Dec 4.


Dihydroergotamine mesylate-loaded dissolving microneedle patch made of polyvinylpyrrolidone for management of acute migraine therapy.

Tas C, Joyce JC, Nguyen HX, Eangoor P, Knaack JS, Banga AK, Prausnitz MR.

J Control Release. 2017 Dec 28;268:159-165. doi: 10.1016/j.jconrel.2017.10.021. Epub 2017 Oct 16.


Microneedle patch delivery of influenza vaccine during pregnancy enhances maternal immune responses promoting survival and long-lasting passive immunity to offspring.

Esser ES, Pulit-Penaloza JA, Kalluri H, McAllister D, Vassilieva EV, Littauer EQ, Lelutiu N, Prausnitz MR, Compans RW, Skountzou I.

Sci Rep. 2017 Jul 18;7(1):5705. doi: 10.1038/s41598-017-05940-7.


The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial.

Rouphael NG, Paine M, Mosley R, Henry S, McAllister DV, Kalluri H, Pewin W, Frew PM, Yu T, Thornburg NJ, Kabbani S, Lai L, Vassilieva EV, Skountzou I, Compans RW, Mulligan MJ, Prausnitz MR; TIV-MNP 2015 Study Group.

Lancet. 2017 Aug 12;390(10095):649-658. doi: 10.1016/S0140-6736(17)30575-5. Epub 2017 Jun 27.

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