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Items: 1 to 20 of 36

1.

Calreticulin exposure on malignant blasts correlates with improved natural killer cell-mediated cytotoxicity in acute myeloid leukemia patients.

Truxova I, Kasikova L, Salek C, Hensler M, Lysak D, Holicek P, Bilkova P, Holubova M, Chen X, Mikyskova R, Reinis M, Kovar M, Tomalova B, Kline JP, Galluzzi L, Spisek R, Fucikova J.

Haematologica. 2019 Oct 3. pii: haematol.2019.223933. doi: 10.3324/haematol.2019.223933. [Epub ahead of print]

2.

Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy.

Spangler JB, Trotta E, Tomala J, Peck A, Young TA, Savvides CS, Silveria S, Votavova P, Salafsky J, Pande VS, Kovar M, Bluestone JA, Garcia KC.

J Immunol. 2018 Oct 1;201(7):2094-2106. doi: 10.4049/jimmunol.1800578. Epub 2018 Aug 13.

3.

Polymer Cancerostatics Targeted with an Antibody Fragment Bound via a Coiled Coil Motif: In Vivo Therapeutic Efficacy against Murine BCL1 Leukemia.

Pechar M, Pola R, Janoušková O, Sieglová I, Král V, Fábry M, Tomalová B, Kovář M.

Macromol Biosci. 2018 Jan;18(1). doi: 10.1002/mabi.201700173. Epub 2017 Sep 15.

PMID:
28921867
4.

Severe, but not mild heat-shock treatment induces immunogenic cell death in cancer cells.

Adkins I, Sadilkova L, Hradilova N, Tomala J, Kovar M, Spisek R.

Oncoimmunology. 2017 Mar 31;6(5):e1311433. doi: 10.1080/2162402X.2017.1311433. eCollection 2017.

5.

Cyclic AMP-Elevating Capacity of Adenylate Cyclase Toxin-Hemolysin Is Sufficient for Lung Infection but Not for Full Virulence of Bordetella pertussis.

Skopova K, Tomalova B, Kanchev I, Rossmann P, Svedova M, Adkins I, Bibova I, Tomala J, Masin J, Guiso N, Osicka R, Sedlacek R, Kovar M, Sebo P.

Infect Immun. 2017 May 23;85(6). pii: e00937-16. doi: 10.1128/IAI.00937-16. Print 2017 Jun.

6.

Caspase-2 and oxidative stress underlie the immunogenic potential of high hydrostatic pressure-induced cancer cell death.

Moserova I, Truxova I, Garg AD, Tomala J, Agostinis P, Cartron PF, Vosahlikova S, Kovar M, Spisek R, Fucikova J.

Oncoimmunology. 2016 Nov 18;6(1):e1258505. doi: 10.1080/2162402X.2016.1258505. eCollection 2017.

7.

Overcoming multidrug resistance via simultaneous delivery of cytostatic drug and P-glycoprotein inhibitor to cancer cells by HPMA copolymer conjugate.

Sivak L, Subr V, Tomala J, Rihova B, Strohalm J, Etrych T, Kovar M.

Biomaterials. 2017 Jan;115:65-80. doi: 10.1016/j.biomaterials.2016.11.013. Epub 2016 Nov 12.

PMID:
27886555
8.

Genotypically Identifying Wheat Mesophyll Conductance Regulation under Progressive Drought Stress.

Olsovska K, Kovar M, Brestic M, Zivcak M, Slamka P, Shao HB.

Front Plant Sci. 2016 Aug 8;7:1111. doi: 10.3389/fpls.2016.01111. eCollection 2016.

9.

Applying hyperspectral imaging to explore natural plant diversity towards improving salt stress tolerance.

Sytar O, Brestic M, Zivcak M, Olsovska K, Kovar M, Shao H, He X.

Sci Total Environ. 2017 Feb 1;578:90-99. doi: 10.1016/j.scitotenv.2016.08.014. Epub 2016 Aug 11. Review.

PMID:
27524726
10.

IL-2/anti-IL-2 mAb immunocomplexes: A renascence of IL-2 in cancer immunotherapy?

Tomala J, Kovar M.

Oncoimmunology. 2015 Nov 3;5(3):e1102829. eCollection 2016 Mar. Review.

11.

Polymer inhibitors of ABC transporter overcoming multidrug resistance: Synthesis, characterization and in vitro evaluation.

Šubr V, Koziolová E, Sivák L, Říhová B, Kovář M, Ulbrich K.

J Control Release. 2015 Sep 10;213:e107-8. doi: 10.1016/j.jconrel.2015.05.180. Epub 2015 Aug 19. No abstract available.

PMID:
27005035
12.

The structure-dependent toxicity, pharmacokinetics and anti-tumour activity of HPMA copolymer conjugates in the treatment of solid tumours and leukaemia.

Tomalova B, Sirova M, Rossmann P, Pola R, Strohalm J, Chytil P, Cerny V, Tomala J, Kabesova M, Rihova B, Ulbrich K, Etrych T, Kovar M.

J Control Release. 2016 Feb 10;223:1-10. doi: 10.1016/j.jconrel.2015.12.023. Epub 2015 Dec 18.

PMID:
26708020
13.

Novel IL-2-Poly(HPMA)Nanoconjugate Based Immunotherapy.

Votavova P, Tomala J, Subr V, Strohalm J, Ulbrich K, Rihova B, Kovar M.

J Biomed Nanotechnol. 2015 Sep;11(9):1662-73.

PMID:
26485935
14.

Pore-formation by adenylate cyclase toxoid activates dendritic cells to prime CD8+ and CD4+ T cells.

Svedova M, Masin J, Fiser R, Cerny O, Tomala J, Freudenberg M, Tuckova L, Kovar M, Dadaglio G, Adkins I, Sebo P.

Immunol Cell Biol. 2016 Apr;94(4):322-33. doi: 10.1038/icb.2015.87. Epub 2015 Oct 6.

PMID:
26437769
15.

Antibodies to Interleukin-2 Elicit Selective T Cell Subset Potentiation through Distinct Conformational Mechanisms.

Spangler JB, Tomala J, Luca VC, Jude KM, Dong S, Ring AM, Votavova P, Pepper M, Kovar M, Garcia KC.

Immunity. 2015 May 19;42(5):815-25. doi: 10.1016/j.immuni.2015.04.015.

16.

Bordetella adenylate cyclase toxin differentially modulates toll-like receptor-stimulated activation, migration and T cell stimulatory capacity of dendritic cells.

Adkins I, Kamanova J, Kocourkova A, Svedova M, Tomala J, Janova H, Masin J, Chladkova B, Bumba L, Kovar M, Ross PJ, Tuckova L, Spisek R, Mills KH, Sebo P.

PLoS One. 2014 Aug 1;9(8):e104064. doi: 10.1371/journal.pone.0104064. eCollection 2014.

17.

Increasing the biological activity of IL-2 and IL-15 through complexing with anti-IL-2 mAbs and IL-15Rα-Fc chimera.

Votavova P, Tomala J, Kovar M.

Immunol Lett. 2014 May-Jun;159(1-2):1-10. doi: 10.1016/j.imlet.2014.01.017. Epub 2014 Feb 7. Review.

PMID:
24512738
18.

HPMA copolymer conjugates of DOX and mitomycin C for combination therapy: physicochemical characterization, cytotoxic effects, combination index analysis, and anti-tumor efficacy.

Kostková H, Etrych T, Ríhová B, Kostka L, Starovoytová L, Kovář M, Ulbrich K.

Macromol Biosci. 2013 Dec;13(12):1648-60. doi: 10.1002/mabi.201300288. Epub 2013 Sep 12.

PMID:
24031022
19.

Chimera of IL-2 linked to light chain of anti-IL-2 mAb mimics IL-2/anti-IL-2 mAb complexes both structurally and functionally.

Tomala J, Kovarova J, Kabesova M, Votavova P, Chmelova H, Dvorakova B, Rihova B, Kovar M.

ACS Chem Biol. 2013 May 17;8(5):871-6. doi: 10.1021/cb3007242. Epub 2013 Mar 5.

PMID:
23419043
20.

Polymer therapeutics with a coiled coil motif targeted against murine bcl1 leukemia.

Pola R, Laga R, Ulbrich K, Sieglová I, Král V, Fábry M, Kabešová M, Kovář M, Pechar M.

Biomacromolecules. 2013 Mar 11;14(3):881-9. doi: 10.1021/bm3019592. Epub 2013 Feb 14.

PMID:
23373696

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