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Items: 1 to 20 of 40

1.

Cyclic Thiosulfinates and Cyclic Disulfides Selectively Cross-Link Thiols While Avoiding Modification of Lone Thiols.

Donnelly DP, Dowgiallo MG, Salisbury JP, Aluri KC, Iyengar S, Chaudhari M, Mathew M, Miele I, Auclair JR, Lopez SA, Manetsch R, Agar JN.

J Am Chem Soc. 2018 Jun 20;140(24):7377-7380. doi: 10.1021/jacs.8b01136. Epub 2018 Jun 11.

PMID:
29851341
2.

Design and Synthesis of Orally Bioavailable Piperazine Substituted 4(1H)-Quinolones with Potent Antimalarial Activity: Structure-Activity and Structure-Property Relationship Studies.

Neelarapu R, Maignan JR, Lichorowic CL, Monastyrskyi A, Mutka TS, LaCrue AN, Blake LD, Casandra D, Mashkouri S, Burrows JN, Willis PA, Kyle DE, Manetsch R.

J Med Chem. 2018 Feb 22;61(4):1450-1473. doi: 10.1021/acs.jmedchem.7b00738. Epub 2018 Feb 9.

PMID:
29215279
3.

Synthesis, characterization, and cellular localization of a fluorescent probe of the antimalarial 8-aminoquinoline primaquine.

McQueen A, Blake LD, Azhari A, Kemp MT, McGaha TW Jr, Namelikonda N, Larsen RW, Manetsch R, Kyle DE.

Bioorg Med Chem Lett. 2017 Oct 15;27(20):4597-4600. doi: 10.1016/j.bmcl.2017.09.030. Epub 2017 Sep 14.

PMID:
28939120
4.

Menoctone Resistance in Malaria Parasites Is Conferred by M133I Mutations in Cytochrome b That Are Transmissible through Mosquitoes.

Blake LD, Johnson ME, Siegel SV, McQueen A, Iyamu ID, Shaikh AK, Shultis MW, Manetsch R, Kyle DE.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00689-17. doi: 10.1128/AAC.00689-17. Print 2017 Aug.

5.
6.

Characterizing the Antimicrobial Activity of N2,N4-Disubstituted Quinazoline-2,4-Diamines toward Multidrug-Resistant Acinetobacter baumannii.

Fleeman R, Van Horn KS, Barber MM, Burda WN, Flanigan DL, Manetsch R, Shaw LN.

Antimicrob Agents Chemother. 2017 May 24;61(6). pii: e00059-17. doi: 10.1128/AAC.00059-17. Print 2017 Jun.

7.

ICI 56,780 Optimization: Structure-Activity Relationship Studies of 7-(2-Phenoxyethoxy)-4(1H)-quinolones with Antimalarial Activity.

Maignan JR, Lichorowic CL, Giarrusso J, Blake LD, Casandra D, Mutka TS, LaCrue AN, Burrows JN, Willis PA, Kyle DE, Manetsch R.

J Med Chem. 2016 Jul 28;59(14):6943-60. doi: 10.1021/acs.jmedchem.6b00759. Epub 2016 Jul 12.

PMID:
27291102
8.

Spirocyclic chromanes exhibit antiplasmodial activities and inhibit all intraerythrocytic life cycle stages.

Roberts BF, Iyamu ID, Lee S, Lee E, Ayong L, Kyle DE, Yuan Y, Manetsch R, Chakrabarti D.

Int J Parasitol Drugs Drug Resist. 2016 Feb 12;6(1):85-92. doi: 10.1016/j.ijpddr.2016.02.004. eCollection 2016 Apr.

9.

3-Trifluoromethyl-3-aryldiazirine photolabels with enhanced ambient light stability.

Kumar AB, Tipton JD, Manetsch R.

Chem Commun (Camb). 2016 Feb 14;52(13):2729-32. doi: 10.1039/c5cc09518b.

PMID:
26758021
10.

Correction to Antileishmanial Activity of a Series of N(2),N(4)-Disubstituted Quinazoline-2,4-diamines.

Van Horn KS, Zhu X, Pandharkar T, Yang S, Vesely B, Vanaerschot M, Dujardin JC, Rijal S, Kyle DE, Wang MZ, Werbovetz KA, Manetsch R.

J Med Chem. 2016 Jan 28;59(2):775. doi: 10.1021/acs.jmedchem.5b00981. Epub 2016 Jan 12. No abstract available.

PMID:
26754204
11.

SAR refinement of antileishmanial N(2),N(4)-disubstituted quinazoline-2,4-diamines.

Zhu X, Van Horn KS, Barber MM, Yang S, Wang MZ, Manetsch R, Werbovetz KA.

Bioorg Med Chem. 2015 Aug 15;23(16):5182-9. doi: 10.1016/j.bmc.2015.02.020. Epub 2015 Feb 18.

12.

Synthesis and evaluation of a novel adenosine-ribose probe for global-scale profiling of nucleoside and nucleotide-binding proteins.

Mahajan S, Manetsch R, Merkler DJ, Stevens SM Jr.

PLoS One. 2015 Feb 11;10(2):e0115644. doi: 10.1371/journal.pone.0115644. eCollection 2015.

13.

Metal-free arylation of ethyl acetoacetate with hypervalent diaryliodonium salts: an immediate access to diverse 3-aryl-4(1H)-quinolones.

Monastyrskyi A, Namelikonda NK, Manetsch R.

J Org Chem. 2015 Mar 6;80(5):2513-2520. doi: 10.1021/jo5023958. Epub 2015 Feb 24.

14.

Orally bioavailable 6-chloro-7-methoxy-4(1H)-quinolones efficacious against multiple stages of Plasmodium.

Cross RM, Flanigan DL, Monastyrskyi A, LaCrue AN, Sáenz FE, Maignan JR, Mutka TS, White KL, Shackleford DM, Bathurst I, Fronczek FR, Wojtas L, Guida WC, Charman SA, Burrows JN, Kyle DE, Manetsch R.

J Med Chem. 2014 Nov 13;57(21):8860-79. doi: 10.1021/jm500942v. Epub 2014 Oct 22.

15.
16.

Antileishmanial activity of a series of N²,N⁴-disubstituted quinazoline-2,4-diamines.

Van Horn KS, Zhu X, Pandharkar T, Yang S, Vesely B, Vanaerschot M, Dujardin JC, Rijal S, Kyle DE, Wang MZ, Werbovetz KA, Manetsch R.

J Med Chem. 2014 Jun 26;57(12):5141-56. doi: 10.1021/jm5000408. Epub 2014 Jun 17.

17.

Antibacterial activity of a series of N2,N4-disubstituted quinazoline-2,4-diamines.

Van Horn KS, Burda WN, Fleeman R, Shaw LN, Manetsch R.

J Med Chem. 2014 Apr 10;57(7):3075-93. doi: 10.1021/jm500039e. Epub 2014 Mar 31.

PMID:
24625106
18.

In silico characterization of an atypical MAPK phosphatase of Plasmodium falciparum as a suitable target for drug discovery.

Campbell CO, Santiago DN, Guida WC, Manetsch R, Adams JH.

Chem Biol Drug Des. 2014 Aug;84(2):158-68. doi: 10.1111/cbdd.12315. Epub 2014 May 12.

19.

4-(1H)-Quinolones and 1,2,3,4-Tetrahydroacridin-9(10H)-ones prevent the transmission of Plasmodium falciparum to Anopheles freeborni.

Sáenz FE, Lacrue AN, Cross RM, Maignan JR, Udenze KO, Manetsch R, Kyle DE.

Antimicrob Agents Chemother. 2013 Dec;57(12):6187-95. doi: 10.1128/AAC.00492-13. Epub 2013 Sep 30.

20.

Quinolone-3-diarylethers: a new class of antimalarial drug.

Nilsen A, LaCrue AN, White KL, Forquer IP, Cross RM, Marfurt J, Mather MW, Delves MJ, Shackleford DM, Saenz FE, Morrisey JM, Steuten J, Mutka T, Li Y, Wirjanata G, Ryan E, Duffy S, Kelly JX, Sebayang BF, Zeeman AM, Noviyanti R, Sinden RE, Kocken CHM, Price RN, Avery VM, Angulo-Barturen I, Jiménez-Díaz MB, Ferrer S, Herreros E, Sanz LM, Gamo FJ, Bathurst I, Burrows JN, Siegl P, Guy RK, Winter RW, Vaidya AB, Charman SA, Kyle DE, Manetsch R, Riscoe MK.

Sci Transl Med. 2013 Mar 20;5(177):177ra37. doi: 10.1126/scitranslmed.3005029.

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