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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 2
1988 1
1989 2
1990 1
1991 1
1992 2
1995 1
1996 2
1997 3
1998 5
1999 3
2000 4
2001 15
2002 9
2003 3
2004 7
2005 14
2006 8
2007 6
2008 6
2009 8
2010 8
2011 10
2012 10
2013 2
2014 10
2015 15
2016 7
2017 6
2018 6
2019 9
2020 10
2021 11
2022 9
2023 5
2024 3

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208 results

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Page 1
Trained immunity - basic concepts and contributions to immunopathology.
Ochando J, Mulder WJM, Madsen JC, Netea MG, Duivenvoorden R. Ochando J, et al. Among authors: madsen jc. Nat Rev Nephrol. 2023 Jan;19(1):23-37. doi: 10.1038/s41581-022-00633-5. Epub 2022 Oct 17. Nat Rev Nephrol. 2023. PMID: 36253509 Free PMC article. Review.
For example, in systemic lupus erythematosus and systemic sclerosis, trained immunity might contribute to inflammatory activity, which promotes disease progression. In organ transplantation, trained immunity has been associated with acute rejection and suppression of train …
For example, in systemic lupus erythematosus and systemic sclerosis, trained immunity might contribute to inflammatory activity, which promo …
Transplantation Outcomes with Donor Hearts after Circulatory Death.
Schroder JN, Patel CB, DeVore AD, Bryner BS, Casalinova S, Shah A, Smith JW, Fiedler AG, Daneshmand M, Silvestry S, Geirsson A, Pretorius V, Joyce DL, Um JY, Esmailian F, Takeda K, Mudy K, Shudo Y, Salerno CT, Pham SM, Goldstein DJ, Philpott J, Dunning J, Lozonschi L, Couper GS, Mallidi HR, Givertz MM, Pham DT, Shaffer AW, Kai M, Quader MA, Absi T, Attia TS, Shukrallah B, Sun BC, Farr M, Mehra MR, Madsen JC, Milano CA, D'Alessandro DA. Schroder JN, et al. Among authors: madsen jc. N Engl J Med. 2023 Jun 8;388(23):2121-2131. doi: 10.1056/NEJMoa2212438. N Engl J Med. 2023. PMID: 37285526 Clinical Trial.
The primary safety end point was serious adverse events associated with the heart graft at 30 days after transplantation. RESULTS: A total of 180 patients underwent transplantation; 90 (assigned to the circulatory-death group) received a heart donated after circulat …
The primary safety end point was serious adverse events associated with the heart graft at 30 days after transplantation. RESULTS: A …
Delivery of costimulatory blockade to lymph nodes promotes transplant acceptance in mice.
Zhao J, Jung S, Li X, Li L, Kasinath V, Zhang H, Movahedi SN, Mardini A, Sabiu G, Hwang Y, Saxena V, Song Y, Ma B, Acton SE, Kim P, Madsen JC, Sage PT, Tullius SG, Tsokos GC, Bromberg JS, Abdi R. Zhao J, et al. Among authors: madsen jc. J Clin Invest. 2022 Dec 15;132(24):e159672. doi: 10.1172/JCI159672. J Clin Invest. 2022. PMID: 36519543 Free PMC article.
The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Here, we investigated how fibroblastic reticular cells (FRCs) facilitate the tolerance induced by anti-CD40L in a murine model of heart transplantation. ...Depl …
The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Here, we investigated how f …
Trained immunity in organ transplantation.
Ochando J, Fayad ZA, Madsen JC, Netea MG, Mulder WJM. Ochando J, et al. Among authors: madsen jc. Am J Transplant. 2020 Jan;20(1):10-18. doi: 10.1111/ajt.15620. Epub 2019 Oct 28. Am J Transplant. 2020. PMID: 31561273 Free PMC article. Review.
Consistent induction of donor-specific unresponsiveness in the absence of continuous immunosuppressive therapy and toxic effects remains a difficult task in clinical organ transplantation. Transplant immunologists have developed numerous experimental treatments that …
Consistent induction of donor-specific unresponsiveness in the absence of continuous immunosuppressive therapy and toxic effects remains a d …
IL-6 Directed Therapy in Transplantation.
Miller CL, Madsen JC. Miller CL, et al. Among authors: madsen jc. Curr Transplant Rep. 2021;8(3):191-204. doi: 10.1007/s40472-021-00331-4. Epub 2021 Jun 3. Curr Transplant Rep. 2021. PMID: 34099967 Free PMC article. Review.
Recent clinical trials have investigated the use of tocilizumab, an anti-IL-6R mAb, for desensitization and treatment of antibody-mediated rejection (AMR) in kidney transplant recipients, with promising initial results. Further studies are underway investigating the use of …
Recent clinical trials have investigated the use of tocilizumab, an anti-IL-6R mAb, for desensitization and treatment of antibody-mediated r …
Feasibility of xeno-transplantation.
Hoerbelt R, Madsen JC. Hoerbelt R, et al. Among authors: madsen jc. Surg Clin North Am. 2004 Feb;84(1):289-307. doi: 10.1016/S0039-6109(03)00208-1. Surg Clin North Am. 2004. PMID: 15053194 Review.
Within a relatively short time span, a significant number of barriers to xeno-transplantation have been identified and potential solutions generated; however, the survival rates for pig-to-primate heart transplantation remain modest at best, with the longest functio …
Within a relatively short time span, a significant number of barriers to xeno-transplantation have been identified and potential solu …
Extracellular vesicles in allograft rejection and tolerance.
Benichou G, Wang M, Ahrens K, Madsen JC. Benichou G, et al. Among authors: madsen jc. Cell Immunol. 2020 Mar;349:104063. doi: 10.1016/j.cellimm.2020.104063. Epub 2020 Feb 8. Cell Immunol. 2020. PMID: 32087929 Free PMC article. Review.
Extracellular vesicles (EVs), including exosomes, ectosomes and apoptotic vesicles, play an essential role in communication between cells of the innate and adaptive immune systems. Recent studies showed that EVs released after transplantation of allogeneic tissues and orga …
Extracellular vesicles (EVs), including exosomes, ectosomes and apoptotic vesicles, play an essential role in communication between cells of …
Targeting IL-6 to prevent cardiac allograft rejection.
Miller CL, Madsen JC. Miller CL, et al. Among authors: madsen jc. Am J Transplant. 2022 Dec;22 Suppl 4(Suppl 4):12-17. doi: 10.1111/ajt.17206. Am J Transplant. 2022. PMID: 36453706 Free PMC article. Review.
Outcomes following heart transplantation remain suboptimal with acute and chronic rejection being major contributors to poor long-term survival. ...Here, we review experimental and pre-clinical evidence that supports the potential use of IL-6 signaling blockade to improve …
Outcomes following heart transplantation remain suboptimal with acute and chronic rejection being major contributors to poor long-ter …
Progress Toward Cardiac Xenotransplantation.
Pierson RN 3rd, Fishman JA, Lewis GD, D'Alessandro DA, Connolly MR, Burdorf L, Madsen JC, Azimzadeh AM. Pierson RN 3rd, et al. Among authors: madsen jc. Circulation. 2020 Oct 6;142(14):1389-1398. doi: 10.1161/CIRCULATIONAHA.120.048186. Epub 2020 Oct 5. Circulation. 2020. PMID: 33017208 Free PMC article. Review.
Minimizing Ischemia Reperfusion Injury in Xenotransplantation.
Patel PM, Connolly MR, Coe TM, Calhoun A, Pollok F, Markmann JF, Burdorf L, Azimzadeh A, Madsen JC, Pierson RN 3rd. Patel PM, et al. Among authors: madsen jc. Front Immunol. 2021 Sep 9;12:681504. doi: 10.3389/fimmu.2021.681504. eCollection 2021. Front Immunol. 2021. PMID: 34566955 Free PMC article. Review.
The recent dramatic advances in preventing "initial xenograft dysfunction" in pig-to-non-human primate heart transplantation achieved by minimizing ischemia suggests that ischemia reperfusion injury (IRI) plays an important role in cardiac xenotransplantation. ...
The recent dramatic advances in preventing "initial xenograft dysfunction" in pig-to-non-human primate heart transplantation achieved …
208 results