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Items: 9


A mitochondrial RNAi screen defines cellular bioenergetic determinants and identifies an adenylate kinase as a key regulator of ATP levels.

Lanning NJ, Looyenga BD, Kauffman AL, Niemi NM, Sudderth J, DeBerardinis RJ, MacKeigan JP.

Cell Rep. 2014 May 8;7(3):907-17. doi: 10.1016/j.celrep.2014.03.065. Epub 2014 Apr 24.


Mitochondrial morphological features are associated with fission and fusion events.

Westrate LM, Drocco JA, Martin KR, Hlavacek WS, MacKeigan JP.

PLoS One. 2014 Apr 14;9(4):e95265. doi: 10.1371/journal.pone.0095265. eCollection 2014.


The pseudophosphatase MK-STYX physically and genetically interacts with the mitochondrial phosphatase PTPMT1.

Niemi NM, Sacoman JL, Westrate LM, Gaither LA, Lanning NJ, Martin KR, MacKeigan JP.

PLoS One. 2014 Apr 7;9(4):e93896. doi: 10.1371/journal.pone.0093896. eCollection 2014.


Persistent mitochondrial hyperfusion promotes G2/M accumulation and caspase-dependent cell death.

Westrate LM, Sayfie AD, Burgenske DM, MacKeigan JP.

PLoS One. 2014 Mar 14;9(3):e91911. doi: 10.1371/journal.pone.0091911. eCollection 2014.


Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death.

Niemi NM, Lanning NJ, Westrate LM, MacKeigan JP.

PLoS One. 2013;8(1):e53803. doi: 10.1371/journal.pone.0053803. Epub 2013 Jan 10.


Mitochondrial phosphorylation in apoptosis: flipping the death switch.

Niemi NM, MacKeigan JP.

Antioxid Redox Signal. 2013 Aug 20;19(6):572-82. doi: 10.1089/ars.2012.4982. Epub 2012 Dec 7. Review.


Mitochondria in cancer: at the crossroads of life and death.

Fogg VC, Lanning NJ, Mackeigan JP.

Chin J Cancer. 2011 Aug;30(8):526-39. doi: 10.5732/cjc.011.10018. Review.


MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis.

Niemi NM, Lanning NJ, Klomp JA, Tait SW, Xu Y, Dykema KJ, Murphy LO, Gaither LA, Xu HE, Furge KA, Green DR, MacKeigan JP.

Mol Cell Biol. 2011 Apr;31(7):1357-68. doi: 10.1128/MCB.00788-10. Epub 2011 Jan 24.


Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression.

Klomp JA, Petillo D, Niemi NM, Dykema KJ, Chen J, Yang XJ, Sääf A, Zickert P, Aly M, Bergerheim U, Nordenskjöld M, Gad S, Giraud S, Denoux Y, Yonneau L, Méjean A, Vasiliu V, Richard S, MacKeigan JP, Teh BT, Furge KA.

BMC Med Genomics. 2010 Dec 16;3:59. doi: 10.1186/1755-8794-3-59.

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